Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joel Caporoso"'
Autor:
Vasyl Bondarenko, Marta M. Wells, Qiang Chen, Tommy S. Tillman, Kevin Singewald, Matthew J. Lawless, Joel Caporoso, Nicole Brandon, Jonathan A. Coleman, Sunil Saxena, Erik Lindahl, Yan Xu, Pei Tang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date. Here, the authors combine NMR and ESR spectroscopy to determine the full-length ICD stru
Externí odkaz:
https://doaj.org/article/d2525994f44840ae925d4fd374218a26
Autor:
Nilubol Duangjumpa, Joel Caporoso, Matthew J. Panzner, Stephanie M. Bilinovich, Jeremy W. Prokop, Thomas C. Leeper, Alexandra Taraboletti, Leah P. Shriver, Daniel L. Morris
Publikováno v:
Biophysica, Vol 1, Iss 27, Pp 359-376 (2021)
Biophysica
Volume 1
Issue 4
Pages 27-376
Biophysica
Volume 1
Issue 4
Pages 27-376
Glutaredoxins (GRXs) are a class of enzymes used in the reduction of protein thiols and the removal of reactive oxygen species. The CPYC active site of GRX is a plausible metal binding site, but was previously theorized not to bind metals due to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5eb0ed94b772981e285f1e6470814f
https://www.mdpi.com/2673-4125/1/4/27
https://www.mdpi.com/2673-4125/1/4/27
Autor:
Pei Tang, Lingling Jiang, Mark Moses, Qiang Chen, Tommy S. Tillman, Nicole R. Brandon, Yan Xu, Kerryann Koper, Joel Caporoso
Publikováno v:
ACS Chemical Neuroscience. 11:1006-1012
Developing potent non-opioid pain medications is an integral part of the battle to conquer both chronic pain and the current opioid crisis. Although most screening approaches use in vitro surrogate targets, in vivo screening of analgesic candidates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a32d28e0d30243db14321f0a53bf75
https://doi.org/10.1021/acschemneuro.0c00013
https://doi.org/10.1021/acschemneuro.0c00013
Autor:
Werner J. Geldenhuys, Li Lin, Joel Caporoso, Prabodh Sadana, Yoon-Kwang Lee, Altaf S. Darvesh, Thomas C. Leeper
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:303-308
Elevated triglycerides (TG) contribute towards increased risk for cardiovascular disease. Lipoprotein lipase (LPL) is an enzyme that is responsible for the metabolism of core triglycerides of very-low density lipoproteins (VLDL) and chylomicrons in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e024d7bc669c69183b0caf801e5ea01f
https://doi.org/10.1016/j.bmcl.2016.11.053
https://doi.org/10.1016/j.bmcl.2016.11.053
Autor:
Christopher J. Ziegler, Thomas C. Leeper, Richard S. Herrick, Sailaja Paruchuri, Vinay Kondeti, Joel Caporoso, Kullapa Chanawanno
Publikováno v:
Dalton Transactions. 45:4729-4735
We have synthesized two Re(CO)3-modified lysine complexes (1 and 2), where the metal is attached to the amino acid at the Nε position, via a one-pot Schiff base formation reaction. These compounds can be used in the solid phase synthesis of peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e698bc1c5f16412ecf09d8fcc2e95c
https://doi.org/10.1039/c5dt04694g
https://doi.org/10.1039/c5dt04694g
Autor:
Richard S. Herrick, Sailaja Paruchuri, Vinay Kondeti, Thomas C. Leeper, Joel Caporoso, Kullapa Chanawanno, Christopher J. Ziegler
Publikováno v:
Dalton Trans.. 43:11452-11455
We have synthesized a Re(CO)3-modified lysine via a one-pot Schiff base formation reaction that can be used in the solid phase peptide synthesis of peptides. To demonstrate its potential use, we have attached it to a neurotensin fragment and observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0959aeb2e7ea27f71add16fcb07e9e41
https://doi.org/10.1039/c4dt01129e
https://doi.org/10.1039/c4dt01129e
Autor:
Sunil Saxena, Nicole R. Brandon, Kevin Singewald, Yan Xu, Joel Caporoso, Marta M. Wells, Monica N. Kinde, Vasyl Bondarenko, Matthew J. Lawless, Tommy S. Tillman, Erik Lindahl, Pei Tang, Charles Chen
Publikováno v:
Biophysical Journal. 116:394a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402b0c012bf1a6a92120b5fdb14cc583
https://doi.org/10.1016/j.bpj.2018.11.2133
https://doi.org/10.1016/j.bpj.2018.11.2133