Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joel C. Bronstein"'
Autor:
John D. Knafels, Chris Limberakis, Paul J. Pagano, Murphy Sean T, Joseph S. Warmus, Sandra Lightle, Daniel F. Ortwine, Joel C. Bronstein, Terry Podoll, Clarke Taylor, Igor Mochalkin, Johnson Timothy Allan, Cheryl L. Quinn, Roger J. Brideau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2536-2543
Lipid A is an essential component of the Gram negative outer membrane, which protects the bacterium from attack of many antibiotics. The Lipid A biosynthesis pathway is essential for Gram negative bacterial growth and is unique to these bacteria. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024e0fd9350a7bb1786a91cdbbc95662
https://doi.org/10.1016/j.bmcl.2012.01.140
https://doi.org/10.1016/j.bmcl.2012.01.140
Publikováno v:
Antiviral Research. 51:111-125
Analysis of a large compound library in a high throughput virus infection assay screen identified the benzothiophene PD146626 as a potent and specific inhibitor of herpes simplex virus type 1 (HSV-1) replication. PD146626 possessed an EC 50 and EC 90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b418fe7d4e0809b19cf2b87a864bcbf
https://doi.org/10.1016/s0166-3542(01)00147-4
https://doi.org/10.1016/s0166-3542(01)00147-4
Autor:
Joel C. Bronstein, Peter Craig Weber
Publikováno v:
Protein Expression and Purification. 22:276-285
The origin binding protein (OBP) encoded by the UL9 open reading frame of herpes simplex virus type 1 (HSV-1) plays an essential role in productive infection by promoting the initiation of viral DNA synthesis. In this study, OBP was inducibly express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0acb89962123aacc4a6eb0915c6171
https://doi.org/10.1006/prep.2001.1446
https://doi.org/10.1006/prep.2001.1446
Autor:
Arthur W. Bull, Joel C. Bronstein
Publikováno v:
Archives of Biochemistry and Biophysics. 348:219-225
Oxidation products of linoleic acid, such as 13-hydroxyoctadecadienoic acid (13-HODE), exhibit biological activity in a number of systems. One major metabolic fate of 13-HODE is oxidation to the 2,4-dienone, 13-oxooctadecadienoic acid by an NAD(+)-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acab51dab7837ed52fb3ebd05ba55438
https://doi.org/10.1006/abbi.1997.0364
https://doi.org/10.1006/abbi.1997.0364
Publikováno v:
Life Sciences. 58:2355-2365
Linoleic acid is metabolized by numerous tissues to oxidized derivatives possessing biological activity. In the current experiments, we have investigated the reaction of 13-oxooctadecadienoic acid (13-OXO) and the metabolic precursor 13-hydroxyoctade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2092c6bedc9c3228e23545ec46f06cb6
https://doi.org/10.1016/0024-3205(96)00236-6
https://doi.org/10.1016/0024-3205(96)00236-6
Publikováno v:
Virology. 215:152-164
Alkaline nuclease, a relatively abundant viral phosphoprotein in herpes simplex virus type 1 (HSV-1)- or HSV-2-infected cells, is encoded by a 2.3-kb mRNA (R. H. Costa, K. G. Draper, L. Banks, K. L. Powell, G. Cohen, R. Eisenberg, and E. K. Wagner, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287551b0b74b89dfd5ab1c79656bd149
https://doi.org/10.1006/viro.1996.0018
https://doi.org/10.1006/viro.1996.0018
Publikováno v:
Carcinogenesis. 14:2239-2243
Recently, oxidation products of linoleic acid such as 13-hydroxyoctadecadienoic acid (HODE) have been implicated in the regulation of cellular physiology including the proliferative response to growth factor treatment. In addition, an NAD(+)-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dfa3cbf411c9bf5898aee16389f81d
https://doi.org/10.1093/carcin/14.11.2239
https://doi.org/10.1093/carcin/14.11.2239
Publikováno v:
Gastroenterology. 103:1562-1567
Rectal mucosal ornithine decarboxylase (ODC) activity has been reported to distinguish between patients with and without adenomatous polyps (AP). In the present investigation, ODC activity has been measured in 28 patients with AP and 34 patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f593f62d31aa5931e9442d12bb204510
https://doi.org/10.1016/0016-5085(92)91178-7
https://doi.org/10.1016/0016-5085(92)91178-7
Autor:
Joel C. Bronstein, Arthur W. Bull
Publikováno v:
Carcinogenesis. 11:1699-1704
Recent evidence has suggested that unsaturated carbonyl compounds may be the ultimate mitogens produced from the primary auto-oxidation products of unsaturated fatty acids. The present study has investigated the metabolism of 13-hydroperoxyoctadecand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a164055a4e41e89acefbfbeba166fb0
https://doi.org/10.1093/carcin/11.10.1699
https://doi.org/10.1093/carcin/11.10.1699
Autor:
Rajeshwar Singh, E. Themis Joannides, Brian M. Watson, H. D. Hollis Showalter, Steve Dunham, Tuan P. Tran, Dai Q. Nguyen, Michael D. Huband, Michael Stier, Stephen J. Gracheck, Jia Yeu Liu, John M. Domagala, Joseph P. Sanchez, Joel C. Bronstein, Debra Hanna, Jeffrey W. Gage, Martin A. Shapiro, Edmund L. Ellsworth
Publikováno v:
Journal of medicinal chemistry. 49(22)
The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial gyrase and topoisomerase IV and demonstrate clinically useful antibacterial activity against fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca424807321e11d888cef562e6a525b
https://pubmed.ncbi.nlm.nih.gov/17064062
https://pubmed.ncbi.nlm.nih.gov/17064062