Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Joel C. Barrish"'
Autor:
Rulin Zhao, Bei Wang, Hong Wu, John Hynes Jr., Katerina Leftheris, Balu Balasubramanian, Joel C. Barrish, Bang-Chi Chen
Publikováno v:
ARKIVOC, Vol 2010, Iss 6, Pp 89-95 (2009)
Externí odkaz:
https://doaj.org/article/e40aa32667fe46bb9ff06964b30a6eda
Autor:
Bang-Chi Chen, Rulin Zhao, Bei Wang, Roberto Droghini, Jean Lajeunesse, Pierre Sirard, Masaki Endo, Balu Balasubramanian, Joel C. Barrish
Publikováno v:
ARKIVOC, Vol 2010, Iss 6, Pp 32-38 (2009)
Externí odkaz:
https://doaj.org/article/dc04e1d3755b439780d1f227813f7778
Autor:
Rulin Zhao, Bang-Chi Chen, Mark S. Bednarz, Bei Wang, Amanda P. Skoumbourdis, Joseph E. Sundeen, T. G. Murali Dhar, Edwin J. Iwanowicz, Balu Balasubramanian, Joel C. Barrish
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 36-42 (2007)
Externí odkaz:
https://doaj.org/article/7f97fd4f318845b9a3aed9278b8d475c
Autor:
Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng
Publikováno v:
Journal of Medicinal Chemistry. 65:4291-4317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc68196d2f5ecc2fc360366195341ffb
https://doi.org/10.1021/acs.jmedchem.1c02110
https://doi.org/10.1021/acs.jmedchem.1c02110
Autor:
Anne Rose, Qihong Zhao, Kumaravel Selvakumar, Percy H. Carter, Prakash Anjanappa, Jing Chen, Sandhya Mandlekar, Mary Ellen Cvijic, Andrew J. Tebben, Songmei Xu, Gregory D. Brown, Venkatram Reddy Paidi, Arvind Mathur, Douglas G. Batt, Jian Pang, Joel C. Barrish, Robert J. Cherney, Melissa Yarde, Ragini Vuppugalla
Publikováno v:
ACS Med Chem Lett
[Image: see text] BMS-813160 (compound 3) was identified as a potent and selective CCR2/5 dual antagonist. Compound 3 displayed good permeability at pH = 7.4 in PAMPA experiments and demonstrated excellent human liver microsome stability. Pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d0c6d25f05a8ec4cbd4e45bae9db09
https://doi.org/10.1021/acsmedchemlett.1c00373
https://doi.org/10.1021/acsmedchemlett.1c00373
Autor:
Joel C. Barrish, John Hynes, Ajay Saxena, Natesan Murugesan, Dianlin Xie, Anjaneya Chimalakonda, Stefan Ruepp, Mitalee Das, Richard Rampulla, Durgarao Kantheti, Chunhong Yan, Julie Carman, Jignesh Nagar, Siva Subramani, Qian Ruan, William J. Pitts, Rajeev S. Bhide, Paul A. Elzinga, Venkatram Reddy Paidi, John S. Sack, Mark Fereshteh, Thangavel Soodamani, Amrita Jha Mukherjee, T. Thanga Mariappan, Ramesh Kumar Sistla, Kaushik Ghosh, Debarati Mazumder, Kamalavenkatesh Palanisamy, Deborah A. Holloway, Susan E. Kiefer, John A. Newitt, Satheesh Kesavan Nair, Polimera Subba Rao, Shailesh Dudhgoankar, Percy H. Carter, Xin Li, Srinivas Maddi, S. Pon Saravanakumar, Sreekantha Ratna Kumar, Sucharita Bose
Publikováno v:
ACS Med Chem Lett
[Image: see text] IRAK4 is an attractive therapeutic target for the treatment of inflammatory conditions. Structure guided optimization of a nicotinamide series of inhibitors has been expanded to explore the IRAK4 front pocket. This has resulted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bbdf7e3f4256a866250ac0c4fba45e
https://doi.org/10.1021/acsmedchemlett.0c00082
https://doi.org/10.1021/acsmedchemlett.0c00082
Autor:
Mary Ellen Cvijic, Andrew J. Tebben, Jian Pang, Mary F. Malley, Ruowei Mo, Joseph B. Santella, Songmei Xu, Qihong Zhao, Douglas G. Batt, Jing Chen, Anne Rose, Bei Wang, Hong Shi, Marta Dabros, Anurag S. Srivastava, Percy H. Carter, Purnima Khandelwal, Yang Michael G, Gardner Daniel S, Gregory D. Brown, Sandhya Mandlekar, Michael Galella, Rulin Zhao, Zili Xiao, John V. Duncia, Sarah C. Traeger, Joel C. Barrish, Robert J. Cherney, Soo S. Ko
Publikováno v:
ACS Medicinal Chemistry Letters. 10:300-305
[Image: see text] We encountered a dilemma in the course of studying a series of antagonists of the G-protein coupled receptor CC chemokine receptor-2 (CCR2): compounds with polar C3 side chains exhibited good ion channel selectivity but poor oral bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5aa828abdf2f0d6f0a23ce2ce17d65
https://doi.org/10.1021/acsmedchemlett.8b00439
https://doi.org/10.1021/acsmedchemlett.8b00439
Autor:
Soo S. Ko, James Kempson, Yingru Zhang, Tracy L. Taylor, Kim W. McIntyre, James R. Burke, Luisa Salter-Cid, Shiuhang Yip, Celia D’Arienzo, Aberra Fura, Stacey Skala, Joseph A. Tino, Jun Dai, Chunlei Wang, Joel C. Barrish, Michael Galella, Kathleen M. Gillooly, Bei Wang, Dauh-Rurng Wu, Lorell Discenza, Xiaoping Hou, Arvind Mathur, Richard Rampulla, Dawn Sun, Scott H. Watterson, Mary T. Obermeier, Percy H. Carter, Mark A. Pattoli, Anurag S. Srivastava, Lihong Cheng, Rulin Zhao, Peng Li, Claudine Pulicicchio, Joseph Pawluczyk, Rodney Vickery
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bruton’s tyrosine kinase (BTK) has been shown to play a key role in the pathogenesis of autoimmunity. Therefore, the inhibition of the kinase activity of BTK with a small molecule inhibitor could offer a breakthrough in the clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e4c1b44296b4486a9db31077574eba
https://pubmed.ncbi.nlm.nih.gov/33214829
https://pubmed.ncbi.nlm.nih.gov/33214829
Autor:
Celia D’Arienzo, Ananta Karmakar, Marta Dabros, Michael Galella, Jingwu Duan, John S. Sack, Dhanya Kumar Raut, David S. Weinstein, Andrew T. Pudzianowski, Ding-Ren Shen, Sylwia Stachura, Joel C. Barrish, Arun Kumar Gupta, Huadong Sun, William R. Foster, Javed Khan, Melissa Yarde, Dan Camac, Lauren Haque, Qihong Zhao, Dauh-Rurng Wu, Carolyn A. Weigelt, Faye Wang, Percy H. Carter, Luisa Salter-Cid, Hemalatha Hemagiri, Jenny Xie, T. G. Murali Dhar, Zhonghui Lu, Virna Borowski, Hua Gong, John E. Somerville
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:85-93
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists. However, a majority of these compounds showed potent activity against pregnane X receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1f582e5622499ffe28a2c4e0122b0d
https://doi.org/10.1016/j.bmcl.2017.12.006
https://doi.org/10.1016/j.bmcl.2017.12.006
Autor:
Sidney Pitt, John S. Sack, Vicky Tang, William J. Pitts, Steven H. Spergel, Jonathan Lippy, Junqing Guo, Michael Galella, Mertzman Michael E, Sylwia Stachura, Steven G. Nadler, Aberra Fura, Percy H. Carter, Gary L. Schieven, Luisa Salter-Cid, Kim W. McIntyre, James Kempson, Javed Khan, Lauren Haque, Rosemary Zhang, John S. Tokarski, Guoxiang Shen, Kathleen M. Gillooly, Stephen T. Wrobleski, Joel C. Barrish
[Image: see text] The four members of the Janus family of nonreceptor tyrosine kinases play a significant role in immune function. The JAK family kinase inhibitor, tofacitinib 1, has been approved in the United States for use in rheumatoid arthritis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1a959ab8edd802fd477e946d59e0fb
https://europepmc.org/articles/PMC6421541/
https://europepmc.org/articles/PMC6421541/
