Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Joel C Watts"'
'Prion-like' seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Intra- or extracellular aggregates of proteins are central pathogenic features in most neurodegenerative disorders. The accumulation of such proteins in diseased brains is believed to be the end-stage of a stepwise aggregation of misfolded monomers t
Externí odkaz:
https://doaj.org/article/c1e48e850d5b47848ab565dc12d52b9e
Autor:
Kyla Germain, Raphaella W. L. So, Laura F. DiGiovanni, Joel C. Watts, Robert H. J. Bandsma, Peter K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Selective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substrate
Externí odkaz:
https://doaj.org/article/18ecadce35a342f9bfce9d364020dabe
Autor:
Daniel J Walsh, Judy R Rees, Surabhi Mehra, Matthew E C Bourkas, Lech Kaczmarczyk, Erica Stuart, Walker S Jackson, Joel C Watts, Surachai Supattapone
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012087 (2024)
Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious versions, while mutant prions cause inherited variants like fatal familial insomnia (FFI)
Externí odkaz:
https://doaj.org/article/bc72e3d470f04611b70c93e0829e5d34
Autor:
Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of
Externí odkaz:
https://doaj.org/article/0a11f0c8776346f5aa6f04e52680ec2e
Autor:
Declan Williams, Bei Qi Yan, Hansen Wang, Logine Negm, Christopher Sackmann, Claire Verkuyl, Vanessa Rezai-Stevens, Shehab Eid, Nimit Vediya, Christine Sato, Joel C. Watts, Holger Wille, Gerold Schmitt-Ulms
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s disease (AD). Missing have been in vivo data in a relevant Aβ amyloidosis model. Here we c
Externí odkaz:
https://doaj.org/article/c75b27984a3d486f870a342af747fc07
Autor:
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy corre
Externí odkaz:
https://doaj.org/article/a8896966164644b4a18d3e1c9d1ee7a0
Autor:
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the br
Externí odkaz:
https://doaj.org/article/311ee78e40194926b8b50a33d61a9ceb
Autor:
Maxime Bélondrade, Simon Nicot, Charly Mayran, Lilian Bruyere-Ostells, Florian Almela, Michele A. Di Bari, Etienne Levavasseur, Joel C. Watts, Chantal Fournier-Wirth, Sylvain Lehmann, Stéphane Haïk, Romolo Nonno, Daisy Bougard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Unlike variant Creutzfeldt–Jakob disease prions, sporadic Creutzfeldt–Jakob disease prions have been shown to be difficult to amplify in vitro by protein misfolding cyclic amplification (PMCA). We assessed PMCA of pathological prion prot
Externí odkaz:
https://doaj.org/article/49816cda18ac44b7b8c29880c7045392
Autor:
Declan Williams, Mohadeseh Mehrabian, Hamza Arshad, Shehab Eid, Christopher Sackmann, Wenda Zhao, Xinzhu Wang, Farinaz Ghodrati, Claire E Verkuyl, Joel C Watts, Gerold Schmitt-Ulms
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0258682 (2021)
The prion protein (PrP) is best known for its ability to cause fatal neurodegenerative diseases in humans and animals. Here, we revisited its molecular environment in the brain using a well-developed affinity-capture mass spectrometry workflow that o
Externí odkaz:
https://doaj.org/article/2a6e7645933d479ea87063ce25ab1eef
Autor:
Hamza Arshad, Zeel Patel, Genki Amano, Le yao Li, Zaid A. M. Al‐Azzawi, Surachai Supattapone, Gerold Schmitt‐Ulms, Joel C. Watts
Publikováno v:
Journal of Neurochemistry. 165:230-245
The bank vole (BV) prion protein (PrP) can function as a universal acceptor of prions. However, the molecular details of BVPrP's promiscuity for replicating a diverse range of prion strains remain obscure. To develop a cultured cell paradigm capable