Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Joel C, Bornstein"'
Autor:
Haozhe Wang, Kristian Barry, Aidil Zaini, Gillian Coakley, Mati Moyat, Carmel P Daunt, Lakshanie C Wickramasinghe, Rossana Azzoni, Roxanne Chatzis, Bibek Yumnam, Mali Camberis, Graham Le Gros, Olaf Perdijk, Jaime P P Foong, Joel C Bornstein, Benjamin J Marsland, Nicola L Harris
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1011766 (2024)
Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and sweep' response characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its intestinal habitat. Recent
Externí odkaz:
https://doaj.org/article/36ebdfe1069a4be6ad32d6752f7b22f2
Autor:
Suzanne Hosie, Tanya Abo-Shaban, Kevin Mou, Gayathri K. Balasuriya, Mitra Mohsenipour, Mohammed U. Alamoudi, Rhiannon T. Filippone, Gabrielle T. Belz, Ashley E. Franks, Joel C. Bornstein, Kulmira Nurgali, Elisa L. Hill-Yardin
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 832 (2024)
Individuals with autism often experience gastrointestinal issues but the cause is unknown. Many gene mutations that modify neuronal synapse function are associated with autism and therefore may impact the enteric nervous system that regulates gastroi
Externí odkaz:
https://doaj.org/article/7b4d1b55652c4aaaa59a3afc96595aaf
Autor:
Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-30 (2022)
Abstract Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological trigger of depressive symptoms is theorised to be inflammation within the central nervous system. It is believe
Externí odkaz:
https://doaj.org/article/4589b47dd1544a099ad741c81bf1a025
Autor:
Madushani Herath, Ellie Cho, Ulrika Marklund, Ashley E. Franks, Joel C. Bornstein, Elisa L. Hill-Yardin
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1063 (2023)
Mutations in the Neuroligin-3 (Nlgn3) gene are implicated in autism spectrum disorder (ASD) and gastrointestinal (GI) dysfunction, but cellular Nlgn3 expression in the enteric nervous system remains to be characterised. We combined RNAScope in situ h
Externí odkaz:
https://doaj.org/article/8d652b5e6c184db0b5312a586c85ac07
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1009717 (2022)
Transmission between neurons in the extensive enteric neural networks of the gut involves synaptic potentials with vastly different time courses and underlying conductances. Most enteric neurons exhibit fast excitatory post-synaptic potentials (EPSPs
Externí odkaz:
https://doaj.org/article/74aaebd734674d34aef792c1d719eb21
Autor:
Anita J. L. Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir, Anthony J. Hannan, Lincon A. Stamp, Marlene M. Hao, Joel C. Bornstein
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 139 (2023)
Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic glutamate receptors (mGlu1 and mGlu5) have established roles in excitatory neurotransmission and synaptic plasticity. Wh
Externí odkaz:
https://doaj.org/article/0822ba6f544e4a85955bb65e6076b976
Autor:
Rhian Stavely, Lauren Sahakian, Rhiannon T. Filippone, Vanesa Stojanovska, Joel C. Bornstein, Samy Sakkal, Kulmira Nurgali
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1831 (2022)
High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern released by dying cells to stimulate the immune response. During cell death, HMGB1 is translocated from the nucleus to the cytoplasm and passively released. High levels of sec
Externí odkaz:
https://doaj.org/article/70cf50452d6f465686deeaf42b08e7f2
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Women are more susceptible to functional bowel disorders than men and the severity of their symptoms such as diarrhea, constipation, abdominal pain and bloating changes over the menstrual cycle, suggesting a role for sex hormones in gastrointestinal
Externí odkaz:
https://doaj.org/article/dbeb44496acf47bb974dbb86b82d5baf
Autor:
Rhiannon T. Filippone, Narges Dargahi, Rajaraman Eri, Jose A. Uranga, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7780 (2022)
Eosinophils and their regulatory molecules have been associated with chronic intestinal inflammation and gastrointestinal dysfunctions; eosinophil accumulation in the gut is prominent in inflammatory bowel disease (IBD). The chemokine receptor CCR3 p
Externí odkaz:
https://doaj.org/article/c20cd76b204b41f58f3da77ccac51b54
Autor:
Christina M. Wright, Sabine Schneider, Kristen M. Smith-Edwards, Fernanda Mafra, Anita J.L. Leembruggen, Michael V. Gonzalez, Deepika R. Kothakapa, Jessica B. Anderson, Beth A. Maguire, Tao Gao, Tricia A. Missall, Marthe J. Howard, Joel C. Bornstein, Brian M. Davis, Robert O. Heuckeroth
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1548-1592.e1 (2021)
Background and Aims: Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate development of novel therapeutic approaches to treat devastating enteri
Externí odkaz:
https://doaj.org/article/f6bf47349bfc4a949f1e3010027e4391