Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Joel B. Berletch"'
Autor:
Wenxiu Ma, He Fang, Nicolas Pease, Galina N. Filippova, Christine M. Disteche, Joel B. Berletch
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-17 (2022)
Highlights The majority of KDM6A targets are regulated from one allele or the other with allelic downregulation showing a maternal allele bias. Kdm6a knockout affects genes that have been implicated in phenotypes of Kabuki syndrome caused by KDM6A mu
Externí odkaz:
https://doaj.org/article/1c11c9b3996d4474b360b8c7cec490c4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
X inactivation represents a complex multi-layer epigenetic mechanism that profoundly modifies chromatin composition and structure of one X chromosome in females. The heterochromatic inactive X chromosome adopts a unique 3D bipartite structure and a l
Externí odkaz:
https://doaj.org/article/45e28e96962e4f50a49c25d507cff4a3
Autor:
Joel B. Berletch, Wenxiu Ma, Fan Yang, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 761-769 (2015)
X chromosome inactivation (XCI) is a female-specific mechanism that serves to balance gene dosage between the sexes whereby one X chromosome in females is inactivated during early development. Despite this silencing, a small portion of genes escape i
Externí odkaz:
https://doaj.org/article/94343594b6494fc3b20a2670c75002bf
Autor:
He Fang, Ana R. Tronco, Giancarlo Bonora, Truong Nguyen, Jitendra Thakur, Joel B. Berletch, Galina N. Filippova, Steven Henikoff, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng
Publikováno v:
bioRxiv
BackgroundThe number and escape levels of genes that escape X chromosome inactivation (XCI) in female somatic cells vary among tissues and cell types, potentially contributing to specific sex differences. Here we investigate the role of CTCF, a maste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea792242ecf59a813af98b444a56935
https://europepmc.org/articles/PMC10187265/
https://europepmc.org/articles/PMC10187265/
Autor:
Galina N. Filippova, Christine M. Disteche, Joel B. Berletch, He Fang, Nicolas Pease, Wenxiu Ma
Publikováno v:
SSRN Electronic Journal.
SUMMARYKDM6A demethylates the repressive histone mark H3K27me3 and thus plays an important role in developmental gene regulation. KDM6A expression is female-biased due to escape from X inactivation, suggesting that this protein may play a role in sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b48dec75a05d0cc85ccfa5f815820a9
https://doi.org/10.2139/ssrn.3345548
https://doi.org/10.2139/ssrn.3345548
Autor:
Jay Shendure, Frank J. Steemers, Yi Yin, Yue Jiang, Joel B. Berletch, William Stafford Noble, Andrew Adey, Christine M. Disteche
We developed “sci-LIANTI”, a high-throughput, high-coverage single-cell DNA sequencing method that combines single-cell combinatorial indexing (“sci”) and linear amplification via transposon insertion (“LIANTI”). To characterize rare chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c19ee67c481e0bc93f07b0f21beaa8
Autor:
Joel B. Berletch, William Stafford Noble, Xinxian Deng, Ruolan Qui, Giancarlo Bonora, Vijay Ramani, Christine M. Disteche, Jay Schendure, Gala N Filippova, He Fang, Zhijun Duan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts, separated by a hinge region. Using Hi-C in edited mouse cells with allelic deletions or inversions within the hinge,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ccbd34d9981f7c4278ba7409ee43c6
https://doi.org/10.1038/s41467-018-03694-y
https://doi.org/10.1038/s41467-018-03694-y
Autor:
Frank J. Steemers, William S DeWitt, Galina N. Filippova, Cole Trapnell, Lena Christiansen, Delasa Aghamirzaie, Andrew J. Hill, Darren A. Cusanovich, Joel B. Berletch, Choli Lee, Hannah A. Pliner, David F. Read, Riza M. Daza, Xingfan Huang, Christine M. Disteche, Samuel G. Regalado, Jay Shendure
Publikováno v:
Cell. 174(5)
We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide chromatin accessibility in ∼100,000 single cells from 13 adult mouse tissues. We identify 85 distinct patterns of chromatin accessibility, most of which can be assigned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce4465ce98ad5fa5f9c12824cbfb229
https://pubmed.ncbi.nlm.nih.gov/30078704
https://pubmed.ncbi.nlm.nih.gov/30078704
Autor:
William Stafford Noble, Wenxiu Ma, Xinxian Deng, Christine M. Disteche, Giancarlo Bonora, Joel B. Berletch
Publikováno v:
Methods in Molecular Biology ISBN: 9781493987658
X chromosome inactivation silences one X chromosome in female mammals. However, this silencing is incomplete, and some genes escape X inactivation. We describe methods to determine the chromosome- wide X inactivation status of genes in tissues or cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710070c50e5419c79b339c32ec69b4ec
https://doi.org/10.1007/978-1-4939-8766-5_15
https://doi.org/10.1007/978-1-4939-8766-5_15
Autor:
Christine M. Disteche, Xinxian Deng, Fan Yang, Jay Shendure, Wenxiu Ma, Joel B. Berletch, William Stafford Noble
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 761-769 (2015)
Data in Brief
Data in Brief
X chromosome inactivation (XCI) is a female-specific mechanism that serves to balance gene dosage between the sexes whereby one X chromosome in females is inactivated during early development. Despite this silencing, a small portion of genes escape i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18555c433bf77bc5ab3823e2f76f7f64
http://www.sciencedirect.com/science/article/pii/S2352340915002814
http://www.sciencedirect.com/science/article/pii/S2352340915002814