HLA variants associated with azathioprine‐induced pancreatitis in patients with Crohn’s disease

Autor: Joel Ås, Ilma Bertulyte, Niclas Eriksson, Patrik K.E. Magnusson, Mia Wadelius, Pär Hallberg

Publikováno v: Clinical and Translational Science, Vol 15, Iss 5, Pp 1249-1256 (2022)

Abstract The immunosuppressant drug azathioprine is associated with a 4% risk of acute pancreatitis in patients with inflammatory bowel disease (IBD). Studies have demonstrated an increased risk in carriers of HLA‐DQA1*02:01 and HLA‐DRB1*07:01. W

Externí odkaz: https://doaj.org/article/2c7725c6d1b64e009908cdf6651b0d00

A theory of appropriateness with applications to generative artificial intelligence

Autor: Leibo, Joel Z., Vezhnevets, Alexander Sasha, Diaz, Manfred, Agapiou, John P., Cunningham, William A., Sunehag, Peter, Haas, Julia, Koster, Raphael, Duéñez-Guzmán, Edgar A., Isaac, William S., Piliouras, Georgios, Bileschi, Stanley M., Rahwan, Iyad, Osindero, Simon

What is appropriateness? Humans navigate a multi-scale mosaic of interlocking notions of what is appropriate for different situations. We act one way with our friends, another with our family, and yet another in the office. Likewise for AI, appropria

Externí odkaz: http://arxiv.org/abs/2412.19010

OpenAI o1 System Card

Autor: OpenAI, Jaech, Aaron, Kalai, Adam, Lerer, Adam, Richardson, Adam, El-Kishky, Ahmed, Low, Aiden, Helyar, Alec, Madry, Aleksander, Beutel, Alex, Carney, Alex, Iftimie, Alex, Karpenko, Alex, Passos, Alex Tachard, Neitz, Alexander, Prokofiev, Alexander, Wei, Alexander, Tam, Allison, Bennett, Ally, Kumar, Ananya, Saraiva, Andre, Vallone, Andrea, Duberstein, Andrew, Kondrich, Andrew, Mishchenko, Andrey, Applebaum, Andy, Jiang, Angela, Nair, Ashvin, Zoph, Barret, Ghorbani, Behrooz, Rossen, Ben, Sokolowsky, Benjamin, Barak, Boaz, McGrew, Bob, Minaiev, Borys, Hao, Botao, Baker, Bowen, Houghton, Brandon, McKinzie, Brandon, Eastman, Brydon, Lugaresi, Camillo, Bassin, Cary, Hudson, Cary, Li, Chak Ming, de Bourcy, Charles, Voss, Chelsea, Shen, Chen, Zhang, Chong, Koch, Chris, Orsinger, Chris, Hesse, Christopher, Fischer, Claudia, Chan, Clive, Roberts, Dan, Kappler, Daniel, Levy, Daniel, Selsam, Daniel, Dohan, David, Farhi, David, Mely, David, Robinson, David, Tsipras, Dimitris, Li, Doug, Oprica, Dragos, Freeman, Eben, Zhang, Eddie, Wong, Edmund, Proehl, Elizabeth, Cheung, Enoch, Mitchell, Eric, Wallace, Eric, Ritter, Erik, Mays, Evan, Wang, Fan, Such, Felipe Petroski, Raso, Filippo, Leoni, Florencia, Tsimpourlas, Foivos, Song, Francis, von Lohmann, Fred, Sulit, Freddie, Salmon, Geoff, Parascandolo, Giambattista, Chabot, Gildas, Zhao, Grace, Brockman, Greg, Leclerc, Guillaume, Salman, Hadi, Bao, Haiming, Sheng, Hao, Andrin, Hart, Bagherinezhad, Hessam, Ren, Hongyu, Lightman, Hunter, Chung, Hyung Won, Kivlichan, Ian, O'Connell, Ian, Osband, Ian, Gilaberte, Ignasi Clavera, Akkaya, Ilge, Kostrikov, Ilya, Sutskever, Ilya, Kofman, Irina, Pachocki, Jakub, Lennon, James, Wei, Jason, Harb, Jean, Twore, Jerry, Feng, Jiacheng, Yu, Jiahui, Weng, Jiayi, Tang, Jie, Yu, Jieqi, Candela, Joaquin Quiñonero, Palermo, Joe, Parish, Joel, Heidecke, Johannes, Hallman, John, Rizzo, John, Gordon, Jonathan, Uesato, Jonathan, Ward, Jonathan, Huizinga, Joost, Wang, Julie, Chen, Kai, Xiao, Kai, Singhal, Karan, Nguyen, Karina, Cobbe, Karl, Shi, Katy, Wood, Kayla, Rimbach, Kendra, Gu-Lemberg, Keren, GuLemberg, Keren, Liu, Kevin, Lu, Kevin, Stone, Kevin, Yu, Kevin, Ahmad, Lama, Yang, Lauren, Liu, Leo, Maksin, Leon, Ho, Leyton, Fedus, Liam, Weng, Lilian, Li, Linden, McCallum, Lindsay, Held, Lindsey, Kuhn, Lorenz, Kondraciuk, Lukas, Kaiser, Lukasz, Metz, Luke, Boyd, Madelaine, Trebacz, Maja, Joglekar, Manas, Chen, Mark, Tintor, Marko, Meyer, Mason, Jones, Matt, Kaufer, Matt, Schwarzer, Max, Shah, Meghan, Yatbaz, Mehmet, Guan, Melody, Xu, Mengyuan, Yan, Mengyuan, Glaese, Mia, Chen, Mianna, Lampe, Michael, Malek, Michael, Wang, Michele, Fradin, Michelle, McClay, Mike, Pavlov, Mikhail, Wang, Miles, Wang, Mingxuan, Murati, Mira, Bavarian, Mo, Rohaninejad, Mostafa, McAleese, Nat, Chowdhury, Neil, Ryder, Nick, Tezak, Nikolas, Brown, Noam, Nachum, Ofir, Boiko, Oleg, Murk, Oleg, Watkins, Olivia, Chao, Patrick, Ashbourne, Paul, Izmailov, Pavel, Zhokhov, Peter, Dias, Rachel, Arora, Rahul, Lin, Randall, Lopes, Rapha Gontijo, Gaon, Raz, Miyara, Reah, Leike, Reimar, Hwang, Renny, Garg, Rhythm, Brown, Robin, James, Roshan, Shu, Rui, Cheu, Ryan, Greene, Ryan, Jain, Saachi, Altman, Sam, Toizer, Sam, Toyer, Sam, Miserendino, Samuel, Agarwal, Sandhini, Hernandez, Santiago, Baker, Sasha, McKinney, Scott, Yan, Scottie, Zhao, Shengjia, Hu, Shengli, Santurkar, Shibani, Chaudhuri, Shraman Ray, Zhang, Shuyuan, Fu, Siyuan, Papay, Spencer, Lin, Steph, Balaji, Suchir, Sanjeev, Suvansh, Sidor, Szymon, Broda, Tal, Clark, Aidan, Wang, Tao, Gordon, Taylor, Sanders, Ted, Patwardhan, Tejal, Sottiaux, Thibault, Degry, Thomas, Dimson, Thomas, Zheng, Tianhao, Garipov, Timur, Stasi, Tom, Bansal, Trapit, Creech, Trevor, Peterson, Troy, Eloundou, Tyna, Qi, Valerie, Kosaraju, Vineet, Monaco, Vinnie, Pong, Vitchyr, Fomenko, Vlad, Zheng, Weiyi, Zhou, Wenda, McCabe, Wes, Zaremba, Wojciech, Dubois, Yann, Lu, Yinghai, Chen, Yining, Cha, Young, Bai, Yu, He, Yuchen, Zhang, Yuchen, Wang, Yunyun, Shao, Zheng, Li, Zhuohan

The o1 model series is trained with large-scale reinforcement learning to reason using chain of thought. These advanced reasoning capabilities provide new avenues for improving the safety and robustness of our models. In particular, our models can re

Externí odkaz: http://arxiv.org/abs/2412.16720

High-fidelity microsecond-scale cellular imaging using two-axis compressed streak imaging fluorescence microscopy

Autor: Keppler, Mark A., O'Connor, Sean P., Steelman, Zachary A., Liu, Xianglei, Liang, Jinyang, Yakovlev, Vladislav V., Bixler, Joel N.

Compressed streak imaging (CSI), introduced in 2014, has proven to be a powerful imaging technology for recording ultrafast phenomena such as light propagation and fluorescence lifetimes at over 150 trillion frames per second. Despite these achieveme

Externí odkaz: http://arxiv.org/abs/2412.16427

Lexicography Saves Lives (LSL): Automatically Translating Suicide-Related Language

Autor: Schoene, Annika Marie, Ortega, John E., Zevallos, Rodolfo Joel, Ihle, Laura Haaber

Recent years have seen a marked increase in research that aims to identify or predict risk, intention or ideation of suicide. The majority of new tasks, datasets, language models and other resources focus on English and on suicide in the context of W

Externí odkaz: http://arxiv.org/abs/2412.15497