Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joel A. Posener"'
Autor:
Andrea Varrone, Per Svenningsson, Katarina Varnäs, Peter Johnström, Anna K. Kirjavainen, Margaret Minkwitz, Zsolt Cselényi, Juha O. Rinne, Nahid Amini, Joel A. Posener, Aurelija Jucaite, Semi Helin, Samantha L. Budd, Alan R. Kugler, Lars Farde, Christer Halldin
Publikováno v:
Brain. 138:2687-2700
Impaired mitochondrial function, oxidative stress and formation of excessive levels of reactive oxygen species play a key role in neurodegeneration in Parkinson’s disease. Myeloperoxidase is a reactive oxygen generating enzyme and is expressed by m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a0536de57e1a2b3f3347b6dc3ccc89
https://doi.org/10.1093/brain/awv184
https://doi.org/10.1093/brain/awv184
Autor:
Gerard Sanacora, Sarah Atkinson, Luis Barra, Michael A Burke, Sanjay J. Mathew, Sanjeev Pathak, Khanh Bui, Michael R Johnson, John Zajecka, Michael Quirk, Juan P Schronen, Joel A. Posener, Timothy Piser, Hong-Lin Su, Robert R Riesenberg, Arif Khan
Publikováno v:
Neuropsychopharmacology
The objective of this study was to investigate the efficacy and safety of adjunctive lanicemine (NMDA channel blocker) in the treatment of major depressive disorder (MDD) over 12 weeks. This phase IIb, randomized, parallel-arm, double-blind, placebo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55802148a4e84379ad137a30b567841f
https://pubmed.ncbi.nlm.nih.gov/27681442
https://pubmed.ncbi.nlm.nih.gov/27681442
Autor:
Brent Solvason, Charles DeBattista, Alan F. Schatzberg, Rowena Gomez, Joel A. Posener, Jennifer Keller
Publikováno v:
Psychoneuroendocrinology. 34:1012-1018
Summary Although many studies have examined separately the effects of depression and cortisol on cognition, no study has examined their relative or potentially additive effects. Our study simultaneously investigated the contributions of clinical stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3762e328188cc89811a024b15f0e619a
https://doi.org/10.1016/j.psyneuen.2009.01.017
https://doi.org/10.1016/j.psyneuen.2009.01.017
Autor:
Gordon H. Williams, Johannes D. Veldhuis, Charles DeBattista, Alan F. Schatzberg, Joel A. Posener, Michael A. Province
Publikováno v:
Psychoneuroendocrinology. 29:1129-1137
Although evidence suggests that major depressive disorder (MDD) is associated with hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, research on basal HPA axis hormone levels in MDD patients has been inconclusive. Definitive characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ddd59c89102a070fa1df341e710c3
https://doi.org/10.1016/j.psyneuen.2004.01.004
https://doi.org/10.1016/j.psyneuen.2004.01.004
Autor:
Joel A. Posener, Michael A. Province, Lei Wang, John G. Csernansky, Mokhtar H. Gado, Casey M. Babb, Joseph L. Price, Michael I. Miller
Publikováno v:
American Journal of Psychiatry. 160:83-89
Abnormalities of the hippocampus may play a role in the pathophysiology of depression, but efforts to identify a structural abnormality in this brain structure among depressed patients have produced mixed results. Previous research may have been limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacfb821619483b4d0839e5433409f69
https://doi.org/10.1176/appi.ajp.160.1.83
https://doi.org/10.1176/appi.ajp.160.1.83
Autor:
Joel A. Posener, John G. Csernansky, Gitry Heydebrand, Lei Wang, Donald Jones, J. Philip Miller, Devna Rastogi-Cruz, Michael I. Miller
Publikováno v:
American Journal of Psychiatry. 159:2000-2006
Abnormalities of hippocampal structure have been reported in schizophrenia subjects. However, such abnormalities have been difficult to discriminate from normal neuroanatomical variation. High dimensional brain mapping, which utilizes probabilistic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cb7b9f6a2fd9e67648488c284f2579
https://doi.org/10.1176/appi.ajp.159.12.2000
https://doi.org/10.1176/appi.ajp.159.12.2000
Autor:
Curtiss J. DuRand, Ree Dawson, Jonathan O. Cole, Maricio Tohen, Carlos A. Zarate, Alan F. Schatzberg, Howard H Chang, Alan I. Green, Ileana Berman, Jayendra K. Patel, Michael D. Banov, Joel A. Posener, Hang Lee, Carol Richards
Publikováno v:
American Journal of Psychiatry. 157:982-986
The efficacy of clozapine was examined in a group of patients with treatment-refractory bipolar disorder, manic type with psychotic features.Twenty-two subjects with treatment-refractory bipolar disorder with active manic and psychotic symptoms parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136636bdd78a4308e872e951dc7be18c
https://doi.org/10.1176/appi.ajp.157.6.982
https://doi.org/10.1176/appi.ajp.157.6.982
Autor:
Alan F. Schatzberg, Nancy L McHale, Joel A. Posener, Jacqueline A. Samson, Gordon H. Williams, Joseph J. Schildkraut, Meghan P Bessette
Publikováno v:
Biological Psychiatry. 45:222-228
Background: Effects of the hypothalamic–pituitary–adrenal (HPA) axis on central dopaminergic systems have been proposed to underlie the development of psychotic symptoms in depression. This study examined HPA axis hormone effects on plasma levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b11dc7d1311d5dcfa583ca94d21c944
https://doi.org/10.1016/s0006-3223(97)00550-7
https://doi.org/10.1016/s0006-3223(97)00550-7
Autor:
Jeffrey Paul, Lyette Richards S, Alice Nichols I, Stephanie McGrory B, Jessica Behrle A, Joel A Posener, Alain Patat, Virginia Parks
Publikováno v:
Journal of Bioequivalence & Bioavailability.
Study background: Assess safety, tolerability, pharmacokinetics, and pharmacodynamics of desvenlafaxine (administered as desvenlafaxine succinate) in 3 studies with healthy volunteers. Methods: Study 1, a randomized, open-label, dose proportionality,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cbe3c5e3da3c05056c6cb6abc015719
https://doi.org/10.4172/jbb.1000130
https://doi.org/10.4172/jbb.1000130
Autor:
Jeffrey Paul, Alice I. Nichols, Tanya Ramey, Joel A Posener, Gabriel Braley, Shannon Lubaczewski, Alain Patat, Jessica A Behrle, Kyle Matschke, Yali Liang
Publikováno v:
Journal of Bioequivalence & Bioavailability.
A series of 3 open-label, 2-period, sequential studies were conducted to assess the impact of desvenlafaxine on cytochrome P450 3A4 (CYP3A4) enzyme-mediated metabolism, and the effect of CYP3A4 inhibition on desvenlafaxine metabolism. Study 1 evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2722377284a11790afef9f6c50934dae
https://doi.org/10.4172/jbb.1000134
https://doi.org/10.4172/jbb.1000134