Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Joel A. Huberman"'
Autor:
Amna Chaudari, Joel A Huberman
Publikováno v:
F1000Research, Vol 1 (2012)
Telomeres of the fission yeast, Schizosaccharomyces pombe, are known to replicate in late S phase, but the reasons for this late replication are not fully understood. We have identified two closely-spaced DNA replication origins, 5.5 to 8 kb upstream
Externí odkaz:
https://doaj.org/article/a339b315aa79427c93e3043ab6a3efbd
Autor:
Martin Weinberger, Li Feng, Anita Paul, Daniel L Smith, Robert D Hontz, Jeffrey S Smith, Marija Vujcic, Keshav K Singh, Joel A Huberman, William C Burhans
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e748 (2007)
The chronological lifespan of eukaryotic organisms is extended by the mutational inactivation of conserved growth-signaling pathways that regulate progression into and through the cell cycle. Here we show that in the budding yeast S. cerevisiae, thes
Externí odkaz:
https://doaj.org/article/c8043480319e44ffa96975d02288a377
Autor:
Joel A Huberman
Publikováno v:
Cell Cycle. 10:873-878
Autor:
Joel A. Huberman, Sanjay Kumar
Publikováno v:
Molecular and Cellular Biology. 29:602-611
To elucidate the checkpoint mechanism responsible for slowing passage through S phase when fission yeast cells are treated with the DNA-damaging agent methyl methanesulfonate (MMS), we carried out two-dimensional gel analyses of replication intermedi
Publikováno v:
Journal of Cell Science. 119:124-131
Previous studies have indicated that replication stress can trigger apoptosis-like cell death, accompanied (where tested) by production of reactive oxygen species (ROS), in mammalian cells and budding yeast (Saccharomyces cerevisiae). In mammalian ce
Autor:
Chulee Yompakdee, Joel A. Huberman
Publikováno v:
Journal of Biological Chemistry. 279:42337-42344
Previous studies in budding yeast suggested that the default firing time of most DNA replication origins is early in S phase and that origins can be forced to fire later by proximity to certain cis-acting sequences. However, these cis-acting sequence
Autor:
Martin Weinberger, Maria A. Marchetti, Lakshmi Ramachandran, William C. Burhans, Joel A. Huberman, Gennaro D'Urso
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 532:227-243
In budding (Saccharomyces cerevisiae) and fission (Schizosaccharomyces pombe) yeast and other unicellular organisms, DNA damage and other stimuli can induce cell death resembling apoptosis in metazoans, including the activation of a recently discover
Autor:
Joel A. Huberman
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 532:1-4
Publikováno v:
Plasmid. 50:113-119
Ars3002 is an efficient single-copy replication origin in the fission yeast, Schizosaccharomyces pombe. In a previous study, we tested the effects of consecutive approximately 50-bp deletions throughout ars3002 on the replication efficiency of those
Publikováno v:
Genes & Development. 17:330-335
Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation fr