Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Joel A Yates"'
1
Akademický článek
Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes.
Autor: Megan A Altemus, Laura E Goo, Andrew C Little, Joel A Yates, Hannah G Cheriyan, Zhi Fen Wu, Sofia D Merajver
Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0220973 (2019)
In breast cancer, tumor hypoxia has been linked to poor prognosis and increased metastasis. Hypoxia activates transcriptional programs in cancer cells that lead to increased motility and invasion, as well as various metabolic changes. One of these me
Externí odkaz: https://doaj.org/article/6e2faa1d21d44102b6ad4e9a6cfac013
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2
Akademický článek
LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
Autor: Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A. Swaim, Eva Rodansky, William K. Storck, Joshua A. Kuleape, Karan Bedi, Rahul Mannan, Xiao-Ming Wang, Aaron Udager, Visweswaran Ravikumar, Armand Bankhead III, Ilsa Coleman, John K. Lee, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Arvind Rao, Zheng Xia, Joel A. Yates, Joshi J. Alumkal
Publikováno v: JCI Insight, Vol 8, Iss 15 (2023)
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation. However, some tumors undergo cellu
Externí odkaz: https://doaj.org/article/e4a07a2910524a9eab732b3ab8ace38b
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4
Akademický článek
The Role of Epigenetic Change in Therapy-Induced Neuroendocrine Prostate Cancer Lineage Plasticity
Autor: William K. Storck, Allison M. May, Thomas C. Westbrook, Zhi Duan, Colm Morrissey, Joel A. Yates, Joshi J. Alumkal
Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)
The androgen receptor (AR) signaling pathway is critical for growth and differentiation of prostate cancer cells. For that reason, androgen deprivation therapy with medical or surgical castration is the principal treatment for metastatic prostate can
Externí odkaz: https://doaj.org/article/8696175c54894aefa79197c1c53aecc8
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5
Akademický článek
Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4
Autor: Daniel J. Coleman, David A. Sampson, Archana Sehrawat, Anbarasu Kumaraswamy, Duanchen Sun, Yuzhuo Wang, Jacob Schwartzman, Joshua Urrutia, Ahn R. Lee, Ilsa M. Coleman, Peter S. Nelson, Xuesen Dong, Colm Morrissey, Eva Corey, Zheng Xia, Joel A. Yates, Joshi J. Alumkal
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 6, Pp 253-262 (2020)
Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is increasing in frequency. In contrast to prostate adenocarcinomas that express a
Externí odkaz: https://doaj.org/article/d5b944dbbb4c47a8814fa347edf364fc
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6
Akademický článek
IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling
Autor: Andrew C. Little, Pragathi Pathanjeli, Zhifen Wu, Liwei Bao, Laura E. Goo, Joel A. Yates, C. Ryan Oliver, Matthew B. Soellner, Sofia D. Merajver
Publikováno v: Frontiers in Oncology, Vol 9 (2019)
Tumor associated macrophages (TAMs) are increasingly recognized as major contributors to the metastatic progression of breast cancer and enriched levels of TAMs often correlate with poor prognosis. Despite our current advances it remains unclear whic
Externí odkaz: https://doaj.org/article/d0ba3a24fe7641e084834f4fbb5997a7
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