Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joel A, Krauser"'
Autor:
Erik Årstad, Adam Badar, Andrew Baxter, John F. Bower, Karl M. Cable, Michael A. Carroll, Melanie Y. T. Chan, Michael Charlton, Martin Christlieb, Bart Cornelissen, Liam R. Cox, Ben Davis, Jonathan R. Dilworth, Ethaar El-Emir, George J. Ellames, Eva Galante, Neil Geach, Antony D. Gee, Véronique Gouverneur, Thomas J. Gregson, David Hendry, Rebekka Hueting, Kamila Hussien, Tenzeela Ilyas, Daniel D. Jenkins, Veerle Kersemans, Eric Knagg, Matthias Koepp, Andrew D. Kohler, Joel A. Krauser, Guillaume G. Launay, William J. S. Lockley, Mark F. Lythgoe, Daniel P. Manthorpe, Andrew McEwen, Ruth J. Muschel, Mark F. Oldfield, Jan Passchier, R. Barbara Pedley, Vineeth Rajkumar, Christopher D. Reed, Mathew Robson, Stephen J. Roe, Jim J. Ryan, Kerstin Sander, Nick Shipley, Sean C. Smart, Neil Smith, Daniel W. Spurr, Keith R. Taylor, Matthew Tredwell, David M. Whitehead, Geoffrey Woolley, Ran Yan
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:50-63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2678f0102323fdd2d061d239eba19777
https://doi.org/10.1002/jlcr.3015
https://doi.org/10.1002/jlcr.3015
Autor:
Ning Cao, Zhili Xin, Jennifer L. Freeman, Bo Liu, Teresa K. Surowy, Rich S. Janis, Hongyu Zhao, Christine A. Collins, Ruojing Yang, Michael D. Serby, Heidi S. Camp, Tom S. Suhar, Philip R. Kym, David W A Beno, Lynch John K, Gang Liu, Steven P Cepa, Harriet T. Smith, Hing L. Sham, Joel A. Krauser
Publikováno v:
Journal of Medicinal Chemistry. 50:3086-3100
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42af278811a494ed64ae2d19357a5e53
https://doi.org/10.1021/jm070219p
https://doi.org/10.1021/jm070219p
Autor:
Joel A. Krauser, F. Peter Guengerich
Publikováno v:
Journal of Biological Chemistry. 280:19496-19506
Testosterone 6beta-hydroxylation is a prototypic reaction of cytochrome P450 (P450) 3A4, the major human P450. Biomimetic reactions produced a variety of testosterone oxidation products with 6beta-hydroxylation being only a minor reaction, indicating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f83bd2a9c236d38dc51825f2ff508f
https://doi.org/10.1074/jbc.m501854200
https://doi.org/10.1074/jbc.m501854200
Autor:
Li-Hong Tseng, Markus Godejohann, F. Peter Guengerich, Alexandre B. Schefer, Markus Voehler, Joel A. Krauser
Publikováno v:
European Journal of Biochemistry. 271:3962-3969
Human cytochrome P450 3A4 forms a series of minor testosterone hydroxylation products in addition to 6 beta-hydroxytestosterone, the major product. One of these, formed at the next highest rate after the 6 beta- and 2 beta-hydroxy products, was ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a9c732ba3ba5557c92fc1eed4db300
https://doi.org/10.1111/j.1432-1033.2004.04339.x
https://doi.org/10.1111/j.1432-1033.2004.04339.x
Publikováno v:
Biochemistry. 43:10775-10788
Several issues regarding the rate-limiting nature of individual reaction steps in catalysis by rabbit liver cytochrome P450 (P450) 1A2 were addressed using anisoles and other substrates. Substrate binding is very fast (k > 10(6) M(-1) s(-1)). Product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25ad2a8156a982f35d2f9bdac1cada2
https://doi.org/10.1021/bi0491393
https://doi.org/10.1021/bi0491393
Autor:
Sophie Schmitt, Laurent Meijer, Pramod Aryal, F. Peter Guengerich, Jennifer L. Sorrells, Joel A. Krauser
Publikováno v:
Journal of Medicinal Chemistry. 47:3236-3241
Indigoids, a class of bis-indoles, represent a promising protein kinase inhibitor scaffold. Oxidation of indole by cytochrome P450 (P450) has been shown to generate species (indoxyl, isatin) that couple to yield indigo and indirubin. Escherichia coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e873f50c86ba45fe669fe731d58805
https://doi.org/10.1021/jm030561b
https://doi.org/10.1021/jm030561b
Autor:
Sophie Langouët, Frédéric Ezan, F. Peter Guengerich, Alain Fautrel, André Guillouzo, Lise Andrieux, Jean F. Savouret, Georges Baffet, Joel A. Krauser
Publikováno v:
Molecular Pharmacology. 65:934-943
The aryl hydrocarbon receptor (AhR) is involved in various processes such as cytochrome P450 (P450) 1A induction after xenobiotic exposure. It is also considered to play a major role in cell proliferation and differentiation. Recent evidences have su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef51bba317a0a23a7dd20219988dbc82
https://doi.org/10.1124/mol.65.4.934
https://doi.org/10.1124/mol.65.4.934
Publikováno v:
Chemical Research in Toxicology. 15:1414-1420
Halogenated olefins are of interest because of their widespread use in industry and their potential toxicity to humans. Epoxides are among the enzymatic oxidation products and have been studied in regard to their toxicity. Most of the attention has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770da9bc3efd65ec6873201ffbf74a18
https://doi.org/10.1021/tx020047t
https://doi.org/10.1021/tx020047t
Publikováno v:
Chemical Research in Toxicology. 15:1096-1105
Tetrachloroethylene, or perchloroethylene (PCE), has considerable industrial use and is of toxicological interest because of a variety of effects. Most of the existing literature presents PCE oxide as a critical intermediate in the oxidative metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d207be6cc3cc6c048d5e2ddf51a9e111
https://doi.org/10.1021/tx020028j
https://doi.org/10.1021/tx020028j
Publikováno v:
Journal of Biological Chemistry. 276:39553-39561
Cytochrome P450 (P450) 2D6 was first identified as the polymorphic human debrisoquine hydroxylase and subsequently shown to catalyze the oxidation of a variety of drugs containing a basic nitrogen. Differences in the regioselectivity of oxidation pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4dcb70b94990dc943569d151d3f1c42
https://doi.org/10.1074/jbc.m106841200
https://doi.org/10.1074/jbc.m106841200