Výsledky vyhledávání - "Joel A, Hirsch"

Akademický článek

Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

Autor: Yacob Gomez-Llorente, Fady Jebara, Malay Patra, Radhika Malik, Shahar Nisemblat, Orna Chomsky-Hecht, Avital Parnas, Abdussalam Azem, Joel A. Hirsch, Iban Ubarretxena-Belandia

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key interme

Externí odkaz: https://doaj.org/article/350b4f4502ee4f4abafe17203699bcde

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Akademický článek

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Growth retardation is most commonly caused by genetic defects in the growth hormone pathway. Here, in families with growth retardation and gingival fibromatosis, the authors identify mutations in the potassium channel gene KCNQ1 that cause electrophy

Externí odkaz: https://doaj.org/article/b5b12ca766544223adfa800c677fab94

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Akademický článek

A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth.

Autor: Ora Hazak, Elad Mamon, Meirav Lavy, Hasana Sternberg, Smrutisanjita Behera, Ina Schmitz-Thom, Daria Bloch, Olga Dementiev, Itay Gutman, Tomer Danziger, Netanel Schwarz, Anas Abuzeineh, Keithanne Mockaitis, Mark Estelle, Joel A Hirsch, Jörg Kudla, Shaul Yalovsky

Publikováno v: PLoS Biology, Vol 17, Iss 7, p e3000085 (2019)

Signaling cross talks between auxin, a regulator of plant development, and Ca2+, a universal second messenger, have been proposed to modulate developmental plasticity in plants. However, the underlying molecular mechanisms are largely unknown. Here,

Externí odkaz: https://doaj.org/article/ee3f0f0f20d4409c909193aec9dbddab

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Akademický článek

The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome

Autor: Heta Huttunen, Matti Hero, Mitja Lääperi, Johanna Känsäkoski, Heikki Swan, Joel A. Hirsch, Päivi J. Miettinen, Taneli Raivio

Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)

ObjectiveTwo missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated e

Externí odkaz: https://doaj.org/article/40034d6901bd4aeba9b7e5807d581704

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Akademický článek

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

Autor: Hilla Fogel, Samuel Frere, Oshik Segev, Shashank Bharill, Ilana Shapira, Neta Gazit, Tiernan O’Malley, Edden Slomowitz, Yevgeny Berdichevsky, Dominic M. Walsh, Ehud Y. Isacoff, Joel A. Hirsch, Inna Slutsky

Publikováno v: Cell Reports, Vol 7, Iss 5, Pp 1560-1576 (2014)

Accumulation of amyloid-β peptides (Aβ), the proteolytic products of the amyloid precursor protein (APP), induces a variety of synaptic dysfunctions ranging from hyperactivity to depression that are thought to cause cognitive decline in Alzheimer�

Externí odkaz: https://doaj.org/article/1bb78f9cf1bf4953b0a4f2b76fc53c01

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Mapping molecular determinants of CaV2.2 inhibition by RGK proteins and homologs in Xenopus oocytes

Autor: Yehezkel Sasson, Suraj Subramaniam, Tal Buki, Lior Almagor, Orna Chomsky-Hecht, Moshe Katz, Henry Puhl, Stephen R. Ikeda, Nathan Dascal, Joel A. Hirsch

The CaV1 and CaV2 families of voltage-dependent calcium channels play a crucial role in neurotransmitter release, excitation-contraction and many other cellular processes. Comprised of the membrane pore-forming α1, intracellular β and extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f4633255754469a601a056dfbea1220
https://doi.org/10.1101/2022.06.21.496996

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Akademický článek

Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.

Autor: Henry L Puhl, Van B Lu, Yu-Jin Won, Yehezkel Sasson, Joel A Hirsch, Fumihito Ono, Stephen R Ikeda

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e100694 (2014)

RGK proteins, Gem, Rad, Rem1, and Rem2, are members of the Ras superfamily of small GTP-binding proteins that interact with Ca2+ channel β subunits to modify voltage-gated Ca2+ channel function. In addition, RGK proteins affect several cellular proc

Externí odkaz: https://doaj.org/article/fd8046e1895c401d9bed8b7237baf166

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Reconstitution of β-adrenergic regulation of Ca

Autor: Moshe, Katz, Suraj, Subramaniam, Orna, Chomsky-Hecht, Vladimir, Tsemakhovich, Veit, Flockerzi, Enno, Klussmann, Joel A, Hirsch, Sharon, Weiss, Nathan, Dascal

Publikováno v: Proc Natl Acad Sci U S A

L-type voltage-gated Ca(V)1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via protein kinase A (PKA)–induced increase of calcium influx through Ca(V)1.2 channels. To dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfe1fbaaeaf5c27c5ae0d16b6afd5c00
https://pubmed.ncbi.nlm.nih.gov/34001616

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