Zobrazeno 1 - 10
of 595 220
pro vyhledávání: '"Joel A"'
Autor:
Bob Schiffrin, Joel A. Crossley, Martin Walko, Jonathan M. Machin, G. Nasir Khan, Iain W. Manfield, Andrew J. Wilson, David J. Brockwell, Tomas Fessl, Antonio N. Calabrese, Sheena E. Radford, Anastasia Zhuravleva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The ATP-independent chaperone SurA protects unfolded outer membrane proteins (OMPs) from aggregation in the periplasm of Gram-negative bacteria, and delivers them to the β-barrel assembly machinery (BAM) for folding into the outer membrane
Externí odkaz:
https://doaj.org/article/b8ce23fd6b774989b970d0af57f9265e
Autor:
Katherine L. Fenn, Jim E. Horne, Joel A. Crossley, Nils Böhringer, Romany J. Horne, Till F. Schäberle, Antonio N. Calabrese, Sheena E. Radford, Neil A. Ranson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The outer membrane is a formidable barrier that protects Gram-negative bacteria against environmental threats. Its integrity requires the correct folding and insertion of outer membrane proteins (OMPs) by the membrane-embedded β-barrel asse
Externí odkaz:
https://doaj.org/article/e2d6b62a22094d6bb6804c36a81d4e8a
Autor:
Andrew Roberts, Eleanor Benterud, Maria J. Santana, Jordan Engbers, Christine Lorenz, Nancy Verdin, Winnie Pearson, Peter Edgar, Joel Adekanye, Pantea Javaheri, Courtney E. MacDonald, Sarah Simmons, Sandra Zelinsky, Jeff Caird, Rick Sawatzky, Bryan Har, William A. Ghali, Colleen M. Norris, Michelle M. Graham, Matthew T. James, Stephen B. Wilton, Tolulope T. Sajobi, for the APPROACH investigators
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract Background Coronary artery disease (CAD) confers increased risks of premature mortality, non-fatal morbidity, and significant impairment in functional status and health-related quality of life. Routine administration of electronic patient-re
Externí odkaz:
https://doaj.org/article/55f7126629784594b2c6790e09bdabfc
Autor:
Anna Halama, Shaza Zaghlool, Gaurav Thareja, Sara Kader, Wadha Al Muftah, Marjonneke Mook-Kanamori, Hina Sarwath, Yasmin Ali Mohamoud, Nisha Stephan, Sabine Ameling, Maja Pucic Baković, Jan Krumsiek, Cornelia Prehn, Jerzy Adamski, Jochen M. Schwenk, Nele Friedrich, Uwe Völker, Manfred Wuhrer, Gordan Lauc, S. Hani Najafi-Shoushtari, Joel A. Malek, Johannes Graumann, Dennis Mook-Kanamori, Frank Schmidt, Karsten Suhre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract In-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and sa
Externí odkaz:
https://doaj.org/article/711d016111244d3c97a32572e4aba254
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-6 (2024)
Abstract Background Bone metastases can compromise the integrity of the spinal canal and cause epidural spinal cord compression (ESCC). The Spinal Instability Neoplastic Score (SINS) was developed in order to evaluate spinal instability due to a neop
Externí odkaz:
https://doaj.org/article/9f06fc2aa5284861beb3547303cbe132
Autor:
David P. Pappas, Mark Field, Cameron J. Kopas, Joel A. Howard, Xiqiao Wang, Ella Lachman, Jinsu Oh, Lin Zhou, Alysson Gold, Gregory M. Stiehl, Kameshwar Yadavalli, Eyob A. Sete, Andrew Bestwick, Matthew J. Kramer, Josh Y. Mutus
Publikováno v:
Communications Materials, Vol 5, Iss 1, Pp 1-7 (2024)
Abstract Superconducting quantum bits (qubits) rely on ultra-thin, amorphous oxide tunneling barriers that can have significant inhomogeneities and defects as grown. This can result in relatively large uncertainties and deleterious effects in the cir
Externí odkaz:
https://doaj.org/article/d20a8d0740a34eadb18fb448e6af70b0
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background With the increased use of patient-reported outcomes measures (PROMs) to assess spine surgery outcomes, it is important to understand how patients interpret their health changes over time. The measurement of cognitive-appraisal pro
Externí odkaz:
https://doaj.org/article/0e630e26cc2f412abf7bb6dce8ae988f
Autor:
Michael J. Osland, Bogdan Chivoiu, James B. Grace, Nicholas M. Enwright, Glenn R. Guntenspergen, Kevin J. Buffington, Karen M. Thorne, Joel A. Carr, William V. Sweet, Brady R. Couvillion
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-8 (2024)
Abstract Accelerated sea-level rise is an existential threat to coastal wetlands, but the timing and extent of wetland drowning are debated. Recent data syntheses have clarified future relative sea-level rise exposure and sensitivity thresholds for d
Externí odkaz:
https://doaj.org/article/71982b65b46b4f5697f02cdfd6cbd6d7
Autor:
Alexandra N. Aquino-Acevedo, Joel A. Orengo-Orengo, Melanie E. Cruz-Robles, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract This review aims to outline mitotic kinase inhibitors’ roles as potential therapeutic targets and assess their suitability as a stand-alone clinical therapy or in combination with standard treatments for advanced-stage solid tumors, includ
Externí odkaz:
https://doaj.org/article/c0344e92c24549a4a58a5e3eb44a159c
Autor:
Jasmin K. Jasuja, Florian Bub, Jonas Veit, Hassan K. M. Fofana, Moussa Sacko, Rénion Saye, Justin K. Chatigre, Eliézer K. N’Goran, Joel A. Yao, Basudha Khanal, Kanika Koirala, Narayan R. Bhattarai, Suman Rijal, Lutz von Müller, Emmanuel Bottieau, Marleen Boelaert, François Chappuis, Katja Polman, Jürg Utzinger, Sören L. Becker
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract In contrast to acute diarrhoea, the aetiology of persistent digestive disorders (≥ 14 days) is poorly understood in low-resource settings and conventional diagnostic approaches lack accuracy. In this multi-country study, we compared multip
Externí odkaz:
https://doaj.org/article/025a279535df434d95fd16c3b803f808