Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joel Renick"'
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Autor:
Jeffrey Vivian, Ali Tabatabaei, Mi Chen, Lindsay Heger, Vincent J. Santora, Chung Demichael, Terence P. Keenan, James Guy Breitenbucher, Jie Chen, Joel Renick, Douglas Zook, Trevor Scott, Guibao Gu, Kathe Stauber
Publikováno v:
Neurochemistry International. 137:104735
Phosphodiesterase 7B (PDE7B) inhibition has been considered as a therapeutic target for the treatment of several neurological disorders. Currently, there are no radio-labeled tracers available to determine receptor occupancy (RO) of this target. Deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0931dae78e13249d61dbd2990bb2eb1e
https://doi.org/10.1016/j.neuint.2020.104735
https://doi.org/10.1016/j.neuint.2020.104735
Autor:
Joel Renick, Jianguo Cao, Michael D. Martin, John Doukas, Ahmed A Kousba, Binqi Zeng, John Hood, Steven Hu, Daniel L. Lohse, Xiyun Yu, Arek Tabak, Glenn Noronha, Shiyin Yee, Richard Soll, Andrew McPherson
Publikováno v:
Drug Metabolism and Disposition. 35:929-936
TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) is a novel multitargeted, orally active protein tyrosine kinase inhibitor. The inhibition constants (K(i)) of TG100435 against Src, Lyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6bed385d6162f4cb1f1e10ac6eb826
https://doi.org/10.1124/dmd.106.014290
https://doi.org/10.1124/dmd.106.014290
Autor:
Chi Ching Mak, Xianchang Gong, Elena Dneprovskaia, Andrew McPherson, Ved P. Pathak, J. Hood, Binqi Zeng, Boris Klebansky, Richard M. Fine, W. Liao, Wolfgang Wrasidlo, Glenn Noronha, Joel Renick, Ningning Zhao, Y. Zhou, Kathy Barrett, Colleen Gritzen, Moorthy S. S. Palanki, Xinshan Kang, Ge Li, Ute Splittgerber, Richard M. Soll, Daniel L. Lohse, Jianguo Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5546-5550
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c3a59d9d64cb5d6108ec85b738a7b4
https://doi.org/10.1016/j.bmcl.2006.08.035
https://doi.org/10.1016/j.bmcl.2006.08.035
Autor:
Barbara Hibner, Nancy Kennure, Bernd Riedl, Donald John Wolanin, Wendy Lee, Xiao-Gao Liu, Reina Natero, Donald Bankston, Hong Rong, Uday Khire, Todd Gane, Roger A. Smith, Robert O. Carlson, Jacques Dumas, Ian McAlexander, Jill Kingery-Wood, Sarah Heald, Timothy B. Lowinger, Jeffrey Johnson, Robert Sibley, James Barbosa, Joel Renick, Michael E Katz, Yolanda V Caringal, David R. Brittelli, Mary-Katherine Monahan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:783-786
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93687468b54d65b2e0109513b7ee5eb5
https://doi.org/10.1016/j.bmcl.2003.11.041
https://doi.org/10.1016/j.bmcl.2003.11.041
Autor:
Chi Ching Mak, Chun P. Chow, Glenn Noronha, Andrew McPherson, Moorthy S.S. Palanki, Joel Renick, Jianguo Cao, Ved P. Pathak, Binqi Zeng, Richard Soll, Elena Dneprovskaia
Publikováno v:
Expert opinion on drug discovery. 4(1)
Background: The synthesis of novel benzotriazine heterocycles was developed independently around the same time by Bischler, Bamberger and Arndt. Over the years, different groups have reported the synthesis of benzotriazine based compounds. Objective:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a190cdf98ee6caf68fde3595fa65cda
https://pubmed.ncbi.nlm.nih.gov/23480335
https://pubmed.ncbi.nlm.nih.gov/23480335
Autor:
Glen Noronha, Jianguo Cao, Chun Chow, Elena Dneprovskaia, Linda Hwang, Dan Lohse, Chi Ching Mak, Andrew McPherson, Richard M. Fine, Xinshan Kang, Boris Klebansky, Moorthy S.S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d4f3146de588732bf746c8ec5d69ab
https://doi.org/10.2174/978160805201110703010121
https://doi.org/10.2174/978160805201110703010121
Autor:
Elena Dneprovskaia, Daniel L. Lohse, Richard Soll, Andrew McPherson, Chi Ching Mak, John Hood, Boris Klebansky, Richard M. Fine, Joel Renick, Jianguo Cao, Chun P. Chow, Moorthy S. S. Palanki, Glenn Noronha, Ved P. Pathak, Binqi Zeng, Xinshan Kang
Publikováno v:
Current topics in medicinal chemistry. 8(10)
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder caused by increased and unregulated growth of myeloid cells in the bone marrow, and the accumulation of excessive white blood cells. Abelson tyrosine kinase (ABL) is a non-recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12165fa94b4010e1abb10fefa72becb6
https://pubmed.ncbi.nlm.nih.gov/18673174
https://pubmed.ncbi.nlm.nih.gov/18673174
Autor:
Ved P. Pathak, Chun P. Chow, Shiyin Yee, Michael D. Martin, Binqi Zeng, Hong Zhu, Shu Kachi, John Doukas, Naoyasu Umeda, Andrew McPherson, Dellamary Luis A, Hideo Akiyama, J. Hood, Boris Klebansky, Moorthy S.S. Palanki, Richard M. Fine, Katsutoshi Yokoi, Peter A. Campochiaro, Ahmed A Kousba, Joel Renick, Glenn Noronha, Dan Lohse, Xinshan Kang, Richard M. Soll, Colleen Gritzen, Chi Ching Mak, Steven Hu, Jianguo Cao
Publikováno v:
Journal of medicinal chemistry. 51(6)
Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60c2e3e531b4630c43bbf6701bffacd
https://pubmed.ncbi.nlm.nih.gov/18311895
https://pubmed.ncbi.nlm.nih.gov/18311895