Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Joe Z. Tsien"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Histone acetylation has been shown to play a crucial role in memory formation, and histone deacetylase (HDAC) inhibitor sodium butyrate (NaB) has been demonstrated to improve memory performance and rescue the neurodegeneration of several Alzheimer’
Externí odkaz:
https://doaj.org/article/4772544c23c74e588a5e7dfd9858b375
Autor:
Meng Li, Joe Z. Tsien
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
A major stumbling block to cracking the real-time neural code is neuronal variability - neurons discharge spikes with enormous variability not only across trials within the same experiments but also in resting states. Such variability is widely regar
Externí odkaz:
https://doaj.org/article/c3941d0bbe84486c9ef613541d72c69e
Publikováno v:
Frontiers in Psychiatry, Vol 7 (2016)
It is not uncommon for humans or animals to experience traumatic events in their lifetimes. However, the majority of individuals are resilient to long-term detrimental changes turning into anxiety and depression, such as post-traumatic stress disorde
Externí odkaz:
https://doaj.org/article/b62b78043cf4490881438b4eec0afea1
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111865 (2014)
The opening-duration of the NMDA receptors implements Hebb's synaptic coincidence-detection and is long thought to be the rate-limiting factor underlying superior memory. Here, we investigate the molecular and genetic determinants of the NMDA recepto
Externí odkaz:
https://doaj.org/article/4b88ec611936408987714d2842ab5c59
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79454 (2013)
Mapping and decoding brain activity patterns underlying learning and memory represents both great interest and immense challenge. At present, very little is known regarding many of the very basic questions regarding the neural codes of memory: are fe
Externí odkaz:
https://doaj.org/article/8d2697cfba604646a0a015ef91e4ef35
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64907 (2013)
There is a general interest in understanding of whether and how exposure to emotionally traumatizing events can alter memory function and anxiety behaviors. Here we have developed a novel laboratory-version of mild blast exposure comprised of high de
Externí odkaz:
https://doaj.org/article/807f59c82bbe465b9bb253d1413469d6
Autor:
Kun Xie, Zhifeng Shi, Liang Chen, Deheng Wang, Hui Kuang, Meng Li, Grace E. Fox, Joe Z. Tsien, Jun Liu, Fang Zhao, Ying Mao
Publikováno v:
Cerebral Cortex. 28:2563-2576
Cracking brain's neural code is of general interest. In contrast to the traditional view that enormous spike variability in resting states and stimulus-triggered responses reflects noise, here, we examine the "Neural Self-Information Theory" that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83904982c946b505a980acc8194caed2
https://doi.org/10.1093/cercor/bhy081
https://doi.org/10.1093/cercor/bhy081
Autor:
Dong V Wang, Joe Z Tsien
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16528 (2011)
The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-
Externí odkaz:
https://doaj.org/article/7522644021e840bdaae603fbbafed412
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15796 (2010)
Visual saliency is the perceptual quality that makes some items in visual scenes stand out from their immediate contexts. Visual saliency plays important roles in natural vision in that saliency can direct eye movements, deploy attention, and facilit
Externí odkaz:
https://doaj.org/article/45a29db07c664610b4eaf7814a558ef4
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15209 (2010)
Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed l
Externí odkaz:
https://doaj.org/article/103cdcc06ade44e5a8cfb79d7a832fe1