Zobrazeno 1 - 10
of 849
pro vyhledávání: '"Joe W Gray"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010505 (2022)
Recent state-of-the-art multiplex imaging techniques have expanded the depth of information that can be captured within a single tissue sample by allowing for panels with dozens of markers. Despite this increase in capacity, space on the panel is sti
Externí odkaz:
https://doaj.org/article/f0a9a6536ed14af9bc74d8fec6104081
Autor:
Yerim Lee, Carey Phelps, Tao Huang, Barmak Mostofian, Lei Wu, Ying Zhang, Kai Tao, Young Hwan Chang, Philip JS Stork, Joe W Gray, Daniel M Zuckerman, Xiaolin Nan
Publikováno v:
eLife, Vol 8 (2019)
Membrane nanodomains have been implicated in Ras signaling, but what these domains are and how they interact with Ras remain obscure. Here, using single particle tracking with photoactivated localization microscopy (spt-PALM) and detailed trajectory
Externí odkaz:
https://doaj.org/article/d27e8702f8fd47e69432bdeac6dc2cfc
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198141 (2018)
Intrinsic and acquired resistance to current HER2 targeted therapies remains a challenge in clinics. We have developed a therapeutic HER2 siRNA delivered using mesoporous silica nanoparticles modified with polymers and conjugated with HER2 targeting
Externí odkaz:
https://doaj.org/article/9858008292274bf0a788e0ebf3769ece
Autor:
Ying Zhang, Tao Huang, Danielle M Jorgens, Andrew Nickerson, Li-Jung Lin, Joshua Pelz, Joe W Gray, Claudia S López, Xiaolin Nan
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176839 (2017)
Sample preparation is critical to biological electron microscopy (EM), and there have been continuous efforts on optimizing the procedures to best preserve structures of interest in the sample. However, a quantitative characterization of the morpholo
Externí odkaz:
https://doaj.org/article/a8f06c4882f24c9aa171de2891903c21
Autor:
James E Korkola, Eric A Collisson, Laura M Heiser, Chris Oates, Nora Bayani, Sleiman Itani, Amanda Esch, Wallace Thompson, Obi L Griffith, Nicholas J Wang, Wen-Lin Kuo, Brian Cooper, Jessica Billig, Safiyyah Ziyad, Jenny L Hung, Lakshmi Jakkula, Heidi Feiler, Yiling Lu, Gordon B Mills, Paul T Spellman, Claire Tomlin, Sach Mukherjee, Joe W Gray
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186551 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0133219.].
Externí odkaz:
https://doaj.org/article/f64d8adeba2f456294eef1b1123c9d8c
Autor:
James E Korkola, Eric A Collisson, Laura Heiser, Chris Oates, Nora Bayani, Sleiman Itani, Amanda Esch, Wallace Thompson, Obi L Griffith, Nicholas J Wang, Wen-Lin Kuo, Brian Cooper, Jessica Billig, Safiyyah Ziyad, Jenny L Hung, Lakshmi Jakkula, Heidi Feiler, Yiling Lu, Gordon B Mills, Paul T Spellman, Claire Tomlin, Sach Mukherjee, Joe W Gray
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133219 (2015)
We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2(+) breast cancers. We accomplished this by measuring cellular and molecular responses to lapatinib and the AKT inhibitors
Externí odkaz:
https://doaj.org/article/01e6b6cfbd714bc98c36f3440a8d060c
Autor:
Timothy M Butler, Katherine Johnson-Camacho, Myron Peto, Nicholas J Wang, Tara A Macey, James E Korkola, Theresa M Koppie, Christopher L Corless, Joe W Gray, Paul T Spellman
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136407 (2015)
The identification of the molecular drivers of cancer by sequencing is the backbone of precision medicine and the basis of personalized therapy; however, biopsies of primary tumors provide only a snapshot of the evolution of the disease and may miss
Externí odkaz:
https://doaj.org/article/23f49c964a624515a3a7d6b15b495858
Autor:
Young Hwan Chang, James Korkola, Dhara N Amin, Mark M Moasser, Jose M Carmena, Joe W Gray, Claire J Tomlin
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121607 (2015)
With the advent of high-throughput measurement techniques, scientists and engineers are starting to grapple with massive data sets and encountering challenges with how to organize, process and extract information into meaningful structures. Multidime
Externí odkaz:
https://doaj.org/article/14a785c35c624705972b50641381164b
Autor:
Leslie M Cope, Mary Jo Fackler, Zoila Lopez-Bujanda, Antonio C Wolff, Kala Visvanathan, Joe W Gray, Saraswati Sukumar, Christopher B Umbricht
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105545 (2014)
It is well documented that tumor cells undergo dramatic genetic and epigenetic changes during initial establishment as cell lines and in subsequent serial passaging, and that the resultant cell lines may have evolved significantly from the primary tu
Externí odkaz:
https://doaj.org/article/9654d6279c754cd59a6c9a6778324d5a
Autor:
Antoine M Snijders, Francesco Marchetti, Sandhya Bhatnagar, Nadire Duru, Ju Han, Zhi Hu, Jian-Hua Mao, Joe W Gray, Andrew J Wyrobek
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45394 (2012)
High dose ionizing radiation (IR) is a well-known risk factor for breast cancer but the health effects after low-dose (LD,
Externí odkaz:
https://doaj.org/article/9d32f0827a7244c4bf0f13796bc208cc