Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joe T, Collins"'
Autor:
Michael David Rogers, Jeffery N. Carroll, Mark A. Massa, Jeffrey Hitchcock, Peter G. Ruminski, Michelle A. Schmidt, Bruce C. Hamper, Strohbach Joseph Walter, Huey S. Shieh, Laurence O. Whiteley, Katherine E. Palmquist, Joe T. Collins, Grace E. Munie, Hanau Cathleen E, H. Peter Kleine, Mark E. Schnute, T. Sunyer, Nicole Caspers, John E. Baldus, Theresa R. Fletcher, Joseph J. McDonald, Silvia Portolan, Jeffrey A. Scholten, Dean Messing, Margaret L. Grapperhaus, Brandon Collins
Publikováno v:
Journal of Medicinal Chemistry. 59:313-327
Matrix metalloproteinase-13 (MMP-13) is a zinc-dependent protease responsible for the cleavage of type II collagen, the major structural protein of articular cartilage. Degradation of this cartilage matrix leads to the development of osteoarthritis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1bf588f2b187240a5d8f4d5ee2e305b
https://doi.org/10.1021/acs.jmedchem.5b01434
https://doi.org/10.1021/acs.jmedchem.5b01434
Autor:
Brad Evans, Keith A. Davis, Joe T. Collins, Keshab Bhattacharya, Anouk Dirksen, Jari I. Finneman, Paul W. Brown, Erin Pepin, Jeffrey S. Ryczek, Ratish Mangalathillam, William B. Wellborn, Mark John Pozzo, Rory F. Finn
Publikováno v:
Biopolymers.
A scalable, viable process was developed for the Fibroblast Growth Factor 21 (FGF21) protein-antibody conjugate, CVX-343, an extended half-life therapeutic for the treatment of metabolic disease. CVX-343 utilizes the CovX antibody scaffold technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88789a43a56b3aaa1e140488c09b7a9f
https://pubmed.ncbi.nlm.nih.gov/28948603
https://pubmed.ncbi.nlm.nih.gov/28948603
Autor:
Joe T. Collins, Steven E. Heasley, Hwang-Fun Lu, Yvette M. Fobian, Allison MacInnes, Michael K. Mao, Tizah Evelyn Anjeh, Michael L. Vazquez, Daniel P. Walker
Publikováno v:
Synlett. 2011:2959-2962
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aef523cf664fd44ce2716061f3401ac
https://doi.org/10.1055/s-0031-1289884
https://doi.org/10.1055/s-0031-1289884
Autor:
Kaliappan Iyanar, Jessica D. Dietz, Graciela B. Arhancet, Horng-Chih Huang, Danny J. Garland, Marcia I. Heron, Silvia I. Pomposiello, Xiao Hu, Len F. Lee, Joe T. Collins, Scott S. Woodard, James Robert Blinn, Maria A. Payne, Brenda L. Case, Rhonda S. Woerndle
Publikováno v:
Journal of Medicinal Chemistry. 53:5970-5978
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288e4053ed7e7f775bce265c4ec3184
https://doi.org/10.1021/jm100506y
https://doi.org/10.1021/jm100506y
Autor:
Grace M. Wagner, Joe T. Collins, Scott S. Woodard, Randal E Numann, Kaliappan Iyanar, Graciela B. Arhancet, Danny J. Garland, James Robert Blinn, Jessica D. Dietz, Horng-Chih Huang, Xiao Hu
Publikováno v:
Journal of Medicinal Chemistry. 53:4300-4304
A number of known 1,4-dihydropyridine CCBs were identified as having comparable potency to the steroidal MR antagonist eplerenone. Chiral resolution of mebudipine revealed that MR and CCB activity reside in opposite enantiomers. Small molecule X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e7af97f6c33d3bb740cfc75d288cac
https://doi.org/10.1021/jm1002827
https://doi.org/10.1021/jm1002827
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Publikováno v:
Organic Process Research & Development. 8:571-575
Studies directed toward the process research and development of a scalable method for preparing tetrahydropyrimidine 2, a key intermediate to the αvβ3 integrin antagonist 1, are described. A linear approach employing 3-amino-5-hydroxybenzoic acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e51ecd058d17a4721b0649981a0c54
https://doi.org/10.1021/op049968w
https://doi.org/10.1021/op049968w
Autor:
Sofya Tsymbalov, M. B. Norton, D. J. Garland, B. S. Pitzele, Timothy J. Hagen, David B. Reitz, Jinglin Li, Michael F. Rafferty, Joe T. Collins, E. A. Hallinan
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea14bc061a20bec0c78c4f88f3fc1471
https://doi.org/10.1002/chin.199423183
https://doi.org/10.1002/chin.199423183
Autor:
David B. Reitz, Xiangyang Chen, James Robert Blinn, Horng-Chih Huang, Kevin F. McGee, Shengtian Yang, Marvin J. Meyers, Jessica D. Dietz, Danny J. Garland, Joseph R. Rico, Graciela B. Arhancet, Joe T. Collins, Maria A. Payne, Matthew W. Mahoney, Susan L. Hockerman, Marcia I. Heron, Xiao Hu, Bruce L. Homer, Scott A. Long, Jay M. Wendling
Publikováno v:
Journal of medicinal chemistry. 53(16)
We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogues were poorly soluble and had a propensity to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f050d0c3dc870966f983df9d6dea1c
https://pubmed.ncbi.nlm.nih.gov/20672822
https://pubmed.ncbi.nlm.nih.gov/20672822
Autor:
Srinivasan R, Nagarajan, Balekudru, Devadas, James W, Malecha, Hwang-Fun, Lu, Peter G, Ruminski, Joseph G, Rico, Thomas E, Rogers, Laura D, Marrufo, Joe T, Collins, H Peter, Kleine, Melissa K, Lantz, Jun, Zhu, Nawasa F, Green, Mark A, Russell, Bryan H, Landis, Lawrence M, Miller, Debra M, Meyer, Tiffany D, Duffin, V Wayne, Engleman, Mary B, Finn, Sandra K, Freeman, David W, Griggs, Melanie L, Williams, Maureen A, Nickols, Jodi A, Pegg, Kristen E, Shannon, Christina, Steininger, Marisa M, Westlin, G Alan, Nickols, Jeffery L, Keene
Publikováno v:
Bioorganicmedicinal chemistry. 15(11)
The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a0bd91c9e67f6a65c308d5b53b9f248
https://pubmed.ncbi.nlm.nih.gov/17399986
https://pubmed.ncbi.nlm.nih.gov/17399986