Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Joe Swift"'
SGOL1-AS1 enhances cell survival in acute myeloid leukemia by maintaining pro-inflammatory signaling
Autor:
Ewan Selkirk, Rahima Patel, Anna Hoyle, Michael Lie-a-Ling, Duncan Smith, Joe Swift, Georges Lacaud
Publikováno v:
Heliyon, Vol 8, Iss 11, Pp e11362- (2022)
Epigenetic dysregulation is a key feature of most acute myeloid leukemia (AML). Recently, it has become clear that long noncoding RNAs (lncRNAs) can play a key role in epigenetic regulation, and consequently also dysregulation. Currently, our underst
Externí odkaz:
https://doaj.org/article/200fb99b57a4430ab65fcfda11acbdb0
Publikováno v:
Polymers, Vol 14, Iss 24, p 5338 (2022)
Cell function can be directly influenced by the mechanical and structural properties of the extracellular environment. In particular, cell morphology and phenotype can be regulated via the modulation of both the stiffness and surface topography of ce
Externí odkaz:
https://doaj.org/article/c267b44876434ee19bc7ae06029cca75
Autor:
Hamish T. J. Gilbert, Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Robert Pedley, Andrew P. Gilmore, Stephen M. Richardson, Joe Swift
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the
Externí odkaz:
https://doaj.org/article/f8f759b44d8640cea035f511934e57db
Autor:
Nisha G Sosale, Irena I Ivanovska, Richard K Tsai, Joe Swift, Jake W Hsu, Cory M Alvey, Philip W Zoltick, Dennis E Discher
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but in vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors are produced here from packaging cells that overexpress “Marker of Self
Externí odkaz:
https://doaj.org/article/460d66d0a2cf46ebae8bc9565a6968bc
Autor:
Jack Llewellyn, Venkatesh Mallikarjun, Ellen Appleton, Maria Osipova, Hamish T. J. Gilbert, Stephen M. Richardson, Simon J. Hubbard, Joe Swift
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of proteotoxic
Autor:
Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Melissa Kidd, Jack Llewellyn, Hamish T. J. Gilbert, Stephen M. Richardson, Joe Swift
Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche experience a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a541fb24c7632ac229665f3bfdd7321
https://doi.org/10.1101/2022.10.09.511462
https://doi.org/10.1101/2022.10.09.511462
Autor:
Robert Pedley, Danielah T. Prescott, Ellen Appleton, Lewis Dingle, James Minshull, Pietro Ivo D’Urso, Ibrahim Djoukhadar, Andrew P. Gilmore, Federico Roncaroli, Joe Swift
BackgroundGlioblastoma is the most common and aggressive primary brain tumour in adults. Hallmarks of glioblastoma include its intra-tumoural heterogeneity and extensive invasion of the surrounding brain. Glioblastoma is known to remodel the extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::894b502ed20d9e84eb2f60628f742a3e
https://doi.org/10.1101/2022.09.01.506199
https://doi.org/10.1101/2022.09.01.506199
Autor:
Teresa Vitali, Tomasz M. Witkos, Marie F.A. Cutiongco, Guanhua Yan, Alexander A. Mironov, Joe Swift, Martin Lowe
The Golgi apparatus comprises a connected ribbon of stacked cisternal membranes localized to the perinuclear region of most vertebrate cells. The position and morphology of this organelle depends upon interactions with microtubules and the actin cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4498a203e3dae45e1a2022b46ee08476
https://doi.org/10.1101/2022.08.25.505293
https://doi.org/10.1101/2022.08.25.505293
Autor:
Ching-Yan Chloé Yeung, Richa Garva, Adam Pickard, Yinhui Lu, Venkatesh Mallikarjun, Joe Swift, Susan H. Taylor, Jyoti Rai, David R. Eyre, Mayank Chaturvedi, Yoshifumi Itoh, Qing-Jun Meng, Cornelia Mauch, Paola Zigrino, Karl E. Kadler
The circadian clock in tendon regulates the daily rhythmic synthesis of collagen-I and the appearance and disappearance of small-diameter collagen fibrils in the extracellular matrix. How the fibrils are assembled and removed is not fully understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11c4ec59d00228e27e12fbca63f583f
https://doi.org/10.1101/2022.04.01.486699
https://doi.org/10.1101/2022.04.01.486699
Autor:
Adam Pickard, Richa Garva, Antony Adamson, Ben Calverley, Anna Hoyle, Christina Hayward, David Spiller, Yinhui Lu, Nigel Hodson, Joe Swift, Brian Bigger, Karl Kadler
Vast numbers of elongated collagen fibrils are assembled in the extracellular matrix during development then persist unchanged throughout life to maintain tissue shape. How cells distinguish between the synthesis of new fibrils and elongation of exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed57122ece2f99ee808d7fc94e4c5450
https://doi.org/10.21203/rs.3.rs-1336021/v1
https://doi.org/10.21203/rs.3.rs-1336021/v1