Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Joe R Delaney"'
RAC‐ing up tumour stemness: Disabled homolog 2 interacting protein and triple‐negative breast cancer
Autor:
Joe R Delaney
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 1, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/3fae40e152ea4e2596d618b07defc2c9
Autor:
Joe R Delaney, Chandni B Patel, Jaidev Bapat, Christian M Jones, Maria Ramos-Zapatero, Katherine K Ortell, Ralph Tanios, Mina Haghighiabyaneh, Joshua Axelrod, John W DeStefano, Isabelle Tancioni, David D Schlaepfer, Olivier Harismendy, Albert R La Spada, Dwayne G Stupack
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008558 (2020)
Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is com
Externí odkaz:
https://doaj.org/article/f42e584000f74e659bc9e24835d7c355
Autor:
Vyacheslav M Labunskyy, Maxim V Gerashchenko, Joe R Delaney, Alaattin Kaya, Brian K Kennedy, Matt Kaeberlein, Vadim N Gladyshev
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004019 (2014)
Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and in
Externí odkaz:
https://doaj.org/article/c0e6ead76b0846d2adf2ec34ad96ba32
Autor:
Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmidt
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002253 (2011)
Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome syste
Externí odkaz:
https://doaj.org/article/cb26d1c7f14d4479b9b28b8bfe0b4d0f
Autor:
Robert R Bowers, Christian M Jones, Edwin A Paz, John K Barrows, Kent E Armeson, David T Long, Joe R Delaney
Publikováno v:
Nucleic Acids Research. 50:3673-3692
Haploinsufficiency drives Darwinian evolution. Siblings, while alike in many aspects, differ due to monoallelic differences inherited from each parent. In cancer, solid tumors exhibit aneuploid genetics resulting in hundreds to thousands of monoallel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ae8a81cc0cb026637cc92a189710bf
https://doi.org/10.1093/nar/gkac200
https://doi.org/10.1093/nar/gkac200
Autor:
Liu Liu, Baicheng Lin, Shasha Yin, Lauren E. Ball, Joe R. Delaney, David T. Long, Wenjian Gan
Publikováno v:
Science advances. 8(49)
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular details of BRD4 regulation remain largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e615195717f55383bc77fe7cd1213f
https://pubmed.ncbi.nlm.nih.gov/36475791
https://pubmed.ncbi.nlm.nih.gov/36475791
Autor:
Seungbeom Ko, Eunbyul Yeom, Yoo Lim Chun, Hyejin Mun, Marina Howard-McGuire, Nathan T. Millison, Junyang Jung, Kwang-Pyo Lee, Changhan Lee, Kyu-Sun Lee, Joe R. Delaney, Je-Hyun Yoon
Publikováno v:
Journal of Lipid and Atherosclerosis
Objective Glucagon in mammals and its homolog (adipokinetic hormone [AKH] in Drosophila melanogaster) are peptide hormones which regulate lipid metabolism by breaking down triglycerides. Although regulatory mechanisms of glucagon and AKH expression h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefe2bc78d358932f97bd851c6ce636c
http://europepmc.org/articles/PMC8792818
http://europepmc.org/articles/PMC8792818
Publikováno v:
Frontiers in Toxicology. 4
Background: Combination therapy of targeted drugs in cancer treatment is a field in constant flux, with research balancing side effects with efficacy. Efficacy from combination therapy is improved either through synthetic lethality or through prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867879b6b3c78da9063ad5e529e4b6a4
https://doi.org/10.3389/ftox.2022.937150
https://doi.org/10.3389/ftox.2022.937150
Autor:
Ping Lu, Christina Voelkel-Johnson, Shai White-Gilbertson, James S. Norris, Stephanie Chiodini, Christian M. Jones, Arabinda Das, Joe R. Delaney, Deborah Hurley
Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 3142-3152 (2020)
Cancer Medicine
Cancer Medicine
Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence. PGCC have the potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d91d98dcb9672de7607e37d4dfe81d
https://doaj.org/article/d1f6ae005b2e4bb4b8b54ea700442373
https://doaj.org/article/d1f6ae005b2e4bb4b8b54ea700442373
Autor:
Robert R. Bowers, Maya F. Andrade, Christian M. Jones, Shai White-Gilbertson, Christina Voelkel-Johnson, Joe R. Delaney
Publikováno v:
BMC cancer. 22(1)
Background Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher than diploid chromosome content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5622ee031695c1c86820af40df8c52b1
https://pubmed.ncbi.nlm.nih.gov/35421971
https://pubmed.ncbi.nlm.nih.gov/35421971