Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Joe Ponte"'
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Abstract B21: Synergistic antitumor immunity observed with combination FRα-targeting antibody-drug conjugate plus anti-PD-1 therapy is CD8+ cell dependent
Autor: Jan Pinkas, Ling Dong, Yulius Setiady, Luke Harris, Sharon Chicklas, L. Cristina Gavrilescu, Richard Gregory, Joe Ponte
Publikováno v: Cancer Immunology Research. 8:B21-B21
Background: Immune checkpoint blockade, specifically targeting PD-1/PD-L1, is a promising approach for cancer therapy. However, for some common cancers, such as epithelial ovarian cancer (EOC), PD1/PDL1 blockade as monotherapy has a low response rate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b56c37782c31f5b98ee519fa33cafd1
https://doi.org/10.1158/2326-6074.tumimm18-b21
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2
Abstract 71: Bystander activity and in vivo efficacy of a folate receptor α (FRα)-targeting antibody-drug conjugate with a novel peptide linker
Autor: Erica Hong, Ravi V. J. Chari, Shan Jin, Erin K. Maloney, Rui Wu, Richard I. Gregory, Thomas A. Keating, Wayne C. Widdison, Lintao Wang, Leanne Lanieri, Olga Ab, Anna Skaletskaya, Yulius Setiady, Qifeng Qiu, Joe Ponte
Publikováno v: Cancer Research. 77:71-71
Folate receptor α (FRα) is an antigen that is overexpressed on the cell surface of solid tumors including ovarian cancer. The differential expression on cancer cells makes FRα an attractive target for antibody-drug conjugates (ADCs), and an ADC ta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec1f6825389dae672dae31c5974865e2
https://doi.org/10.1158/1538-7445.am2017-71
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3
Abstract 1073: Increased internalization and processing of the CD37-targeting antibody-drug conjugate, naratuximab emtansine (IMGN529), in the presence of rituximab leads to enhanced potency in diffuse large B-cell lymphoma models
Autor: Katharine C. Lai, Prerak Shah, Stuart W. Hicks, Cristina Gavrilescu, Angela Romanelli, Yong Yi, Callum M. Sloss, Joe Ponte
Publikováno v: Cancer Research. 77:1073-1073
Naratuximab emtansine (IMGN529) is an investigational CD37-targeting antibody-drug conjugate (ADC) that has shown both preclinical and clinical activity in DLBCL . We have shown that rituximab, an anti-CD20 monoclonal antibody, enhances the preclinic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4aee4c1b9b49198b85fc4d84a2b00670
https://doi.org/10.1158/1538-7445.am2017-1073
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5
Abstract 1618: New peptide-linked anilino-maytansinoid antibody-drug conjugates (ADCs) for the treatment of cancer
Autor: Leanne Lanieri, Juliet Costoplus, Rajeeva Singh, Ling Dong, Charlene Audette, Yulius Setiady, Nathan Fishkin, Ravi V. J. Chari, Jennifer A. Coccia, Rui Wu, Greg Jones, Anja Skaletskaya, Joe Ponte, Karen Veale, Andre Dandeneau, Erin K. Maloney, Sharon D. Wilhelm, Wayne C. Widdison, Luke Harris, Yelena Kovtun
Publikováno v: Cancer Research. 74:1618-1618
A number of ADCs consisting of a maytansinoid cytotoxic agent linked to an antibody via a cleavable disulfide linker or a non-cleavable thioether linker are in the clinic. In preclinical models, antibody-maytansinoid conjugates (AMCs) utilizing a cle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4765b64cbdaf2e7f58686cd9547e76e
https://doi.org/10.1158/1538-7445.am2014-1618
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6
Abstract 4324: Maytansinoid conjugates of a novel type III anti-CD20 antibody with potent antitumor activity
Autor: Jutta Deckert, Lingyun Rui, Jennifer A. Coccia, Leanne Lanieri, Daniel Tavares, Min Li, Thomas Chittenden, Peter U. Park, Erin K. Maloney, Sharon Chicklas, Yong Yi, Joe Ponte, Jan Pinkas, Rui Wu
Publikováno v: Cancer Research. 73:4324-4324
Previously identified anti-CD20 antibodies have been classified as either Type I antibodies with lipid raft and complement-dependent cytotoxicity (CDC) activity or Type II antibodies with strong pro-apoptotic activity, but not both. We describe here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f74746ae53ab4794f6662ef82274d77
https://doi.org/10.1158/1538-7445.am2013-4324
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