Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Joe N. Kornegay"'
Autor:
Dominique O. Riddell, John C. W. Hildyard, Rachel C. M. Harron, Frances Taylor-Brown, Joe N. Kornegay, Dominic J. Wells, Richard J. Piercy
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/c387e8a46e8b41748d428582fea41666
Autor:
Sarah M. Schneider, Garett T. Sansom, Lee-Jae Guo, Shinji Furuya, Brad R. Weeks, Joe N. Kornegay
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2022)
BackgroundDuchenne muscular dystrophy (DMD) is an X-linked inherited myopathy that causes progressive skeletal and cardiac muscle disease. Heart lesions were described in the earliest DMD reports, and cardiomyopathy is now the leading cause of death.
Externí odkaz:
https://doaj.org/article/0393d9035c4542b9bd4bde72b9d9dd62
Autor:
Sara Mata López, James J. Hammond, Madison B. Rigsby, Cynthia J. Balog-Alvarez, Joe N. Kornegay, Peter P. Nghiem
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-6 (2018)
Abstract Background Boys with Duchenne muscular dystrophy (DMD) have DMD gene mutations, with associated loss of the dystrophin protein and progressive muscle degeneration and weakness. Corticosteroids and palliative support are currently the best tr
Externí odkaz:
https://doaj.org/article/eb783a37156645ac8356d2e5603c7c91
Autor:
Yusuke Echigoya, Nhu Trieu, William Duddy, Hong M. Moulton, HaiFang Yin, Terence A. Partridge, Eric P. Hoffman, Joe N. Kornegay, Frank A. Rohret, Christopher S. Rogers, Toshifumi Yokota
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13065 (2021)
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by mutations in the DMD gene and the subsequent lack of dystrophin protein. Recently, phosphorodiamidate morpholino oligomer (PMO)-antisense oligonucleotides (ASOs) targ
Externí odkaz:
https://doaj.org/article/8db7c319f66e47b79bb85b25a5d9eb29
Autor:
Joe N. Kornegay
Publikováno v:
Skeletal Muscle, Vol 7, Iss 1, Pp 1-21 (2017)
Abstract Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the DMD gene and loss of the protein dystrophin. The absence of dystrophin leads to myofiber membrane fragility and necrosis, with eventual muscle atrophy and co
Externí odkaz:
https://doaj.org/article/0d8099eb135e4cb9ad16491dabde2c45
Autor:
Larry W. Markham, Candice L. Brinkmeyer-Langford, Jonathan H. Soslow, Manisha Gupte, Douglas B. Sawyer, Joe N. Kornegay, Cristi L. Galindo
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Background Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, which codes for the dystrophin protein. While progress has been made in defining the molecular basis and pathogenesis of DMD, major gaps remain in understan
Externí odkaz:
https://doaj.org/article/6f852da7d2e2474a811eccd2294ee126
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 62-71 (2017)
Duchenne muscular dystrophy (DMD) is a lethal, X-linked, muscle-wasting disorder caused by mutations in the large, 2.4-Mb dystrophin gene. The majority of DMD-causing mutations are sporadic, multi-exon, frameshifting deletions, with the potential for
Externí odkaz:
https://doaj.org/article/baaed901fbc14b398a47c288c15dcfd1
Autor:
Lee‐Jae Guo, Jonathan H. Soslow, Amanda K. Bettis, Peter P. Nghiem, Kevin J. Cummings, Mark W. Lenox, Matthew W. Miller, Joe N. Kornegay, Christopher F. Spurney
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 16 (2019)
Background Duchenne muscular dystrophy (DMD) is an X‐linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is genetically homologous with
Externí odkaz:
https://doaj.org/article/21520871b58b4c7c9d2cda64abd81fc7
Autor:
Alyson A. Fiorillo, Christopher R. Heier, James S. Novak, Christopher B. Tully, Kristy J. Brown, Kitipong Uaesoontrachoon, Maria C. Vila, Peter P. Ngheim, Luca Bello, Joe N. Kornegay, Corrado Angelini, Terence A. Partridge, Kanneboyina Nagaraju, Eric P. Hoffman
Publikováno v:
Cell Reports, Vol 12, Iss 10, Pp 1678-1690 (2015)
The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In mus
Externí odkaz:
https://doaj.org/article/de3f64e4552f4c9aa4b50be9b61059d2
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1175-1184 (2013)
SUMMARY Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease for which there is no cure and limited treatment options. Prednisone is currently the first line treatment option for DMD and studies have demonstrated that it improves muscle
Externí odkaz:
https://doaj.org/article/7283c488099847fe8b0dfc2e88b55b96