Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joe N Frost"'
Autor:
Sarah K Wideman, Joe N Frost, Felix C Richter, Caitlin Naylor, José M Lopes, Nicole Viveiros, Megan R Teh, Alexandra E Preston, Natasha White, Shamsideen Yusuf, Simon J Draper, Andrew E Armitage, Tiago L Duarte, Hal Drakesmith
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011679 (2023)
Malaria and iron deficiency are major global health problems with extensive epidemiological overlap. Iron deficiency-induced anaemia can protect the host from malaria by limiting parasite growth. On the other hand, iron deficiency can significantly d
Externí odkaz:
https://doaj.org/article/582690d7c2874b0f9da71e246c411f20
Autor:
Elisabeth Littwitz-Salomon, Diana Moreira, Joe N. Frost, Chloe Choi, Kevin T. Liou, David K. Ahern, Simon O’Shaughnessy, Bernd Wagner, Christine A. Biron, Hal Drakesmith, Ulf Dittmer, David K. Finlay
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Metabolic alterations control the fate and function of immune cells in response to infections, but the function of NK cell metabolism in the context of acute viral infections is unclear. Here the authors show that acute NK cell responses to Friend re
Externí odkaz:
https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc27
Autor:
Joe N. Frost, David Arnold, Fergus Hamilton, Akshay Shah, Karen T. Elvers, Alice Milne, Andrew E. Armitage, Marie Attwood, Jorgen McKernon, Luzheng Xue, Peter Ghazal, Yi-Ling Chen, Nicholas M. Provine, Jonathan Youngs, Hal Drakesmith, Tihana Bicanic, Paul Klenerman
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Marked reductions in serum iron concentrations are commonly induced during the acute phase of infection. This phenomenon, termed hypoferremia of inflammation, leads to inflammatory anemia, but could also have broader pathophysiological im
Externí odkaz:
https://doaj.org/article/9e8a2809e69c4cd9a90807bd3fbbf1d6
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-4 (2020)
Externí odkaz:
https://doaj.org/article/dae12bd6e6d249ad9c6b12a40f2717d1
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recent findings have shown that iron is a powerful regulator of immune responses, which is of broad importance because iron deficiency is highly prevalent worldwide. However, the underlying reasons of why iron is needed by lymphocytes remain unclear.
Externí odkaz:
https://doaj.org/article/73488ef543cd45f088afa4d81a16db5a
Autor:
Nicole U. Stoffel, Mary A. Uyoga, Francis M. Mutuku, Joe N. Frost, Edith Mwasi, Daniela Paganini, Fiona R. M. van der Klis, Indu J. Malhotra, A. Desiráe LaBeaud, Cristian Ricci, Simon Karanja, Hal Drakesmith, Charles H. King, Michael B. Zimmermann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain.Meth
Externí odkaz:
https://doaj.org/article/ad33eb28341d4d458c0709843262a595
Autor:
Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoi
Externí odkaz:
https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba
Autor:
Sarah K. Wideman, Joe N. Frost, Felix C. Richter, Caitlin Naylor, José M. Lopes, Nicole Viveiros, Megan R. Teh, Alexandra E. Preston, Natasha White, Shamsideen Yusuf, Simon J. Draper, Andrew E. Armitage, Tiago L. Duarte, Hal Drakesmith
Malaria and iron deficiency are major global health problems with extensive epidemiological overlap. Iron deficiency-induced anaemia can protect the host from malaria by limiting parasite growth. On the other hand, iron deficiency can significantly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f2b46addcbc006cd3dcddfb86e7f613
https://doi.org/10.1101/2023.02.05.527208
https://doi.org/10.1101/2023.02.05.527208
Autor:
Chloe Choi, Ulf Dittmer, David K. Finlay, Kevin T. Liou, David K. Ahern, Diana Moreira, Bernd Wagner, Hal Drakesmith, Joe N. Frost, Elisabeth Littwitz-Salomon, Simon O’Shaughnessy, Christine A. Biron
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Natural killer (NK) cells are important early responders against viral infections. Changes in metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell dysfunction in obesity and cancer. However, very little is kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15df03043c0766db5b6821d09ef4053
https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc27
https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc27
Autor:
Joe N. Frost, Sarah K. Wideman, Alexandra E. Preston, Megan R. Teh, Zhichao Ai, Lihui Wang, Amy Cross, Natasha White, Yavuz Yazicioglu, Michael Bonadonna, Alexander J. Clarke, Andrew E. Armitage, Bruno Galy, Irina A. Udalova, Hal Drakesmith
Publikováno v:
Science Advances. 8
Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4843af6d36c099ded438aec539d695bd
https://doi.org/10.1126/sciadv.abq5384
https://doi.org/10.1126/sciadv.abq5384