Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Joe Henry, Steinbach"'
Autor:
Hong-Jin Shu, Xinguo Lu, John Bracamontes, Joe Henry Steinbach, Charles F. Zorumski, Steven Mennerick
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
GABAA receptors (GABAARs) play a crucial role in inhibition in the central nervous system. GABAARs containing the δ subunit mediate tonic inhibition, have distinctive pharmacological properties and are associated with disorders of the nervous system
Externí odkaz:
https://doaj.org/article/2d6c80293f0b4718b46de2d30e9260f4
Autor:
Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Ariel B. Burbridge, Joe Henry Steinbach, Gustav Akk
Publikováno v:
Physiological Reports, Vol 7, Iss 18, Pp n/a-n/a (2019)
Abstract The synaptic α1β2γ2 GABAA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events when exposed to ambient GABA because of its low resting affinity to the transmi
Externí odkaz:
https://doaj.org/article/b9a7ead828204aaba4558049c76b36dd
Publikováno v:
Current Neuropharmacology. 20:90-93
Background : In electrophysiological experiments inhibition of a receptor-channel, such as the GABAA receptor, is measured by co-applying an agonist producing a predefined control response with an inhibitor to calculate the fraction of the control re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f325df87fea7451054546d4d6b1086
https://doi.org/10.2174/1570159x19666211104142433
https://doi.org/10.2174/1570159x19666211104142433
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151071 (2016)
Epitopes accessible on the surface of intact cells are extremely valuable in studies of membrane proteins, allowing quantification and determination of the distribution of proteins as well as identification of cells expressing large numbers of protei
Externí odkaz:
https://doaj.org/article/8f59c1eabe334d15821ef45558f21053
Autor:
Spencer R. Pierce, David E. Reichert, Gustav Akk, Joe Henry Steinbach, Alex S. Evers, Ariel B. Burbridge, Allison L. Germann
Publikováno v:
Molecular Pharmacology. 98:280-291
The ρ1 GABAA receptor is prominently expressed in the retina and is present at lower levels in several brain regions and other tissues. Although the ρ1 receptor is insensitive to many anesthetic drugs that modulate the heteromeric GABAA receptor, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9745f60cf69cf9cf3cffa06635bf791b
https://doi.org/10.1124/mol.120.119842
https://doi.org/10.1124/mol.120.119842
Autor:
Xiaochun Jin, Joe Henry Steinbach
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144631 (2015)
The endogenous steroid 17β-estradiol (βEST) potentiates activation of neuronal nicotinic receptors containing α4 subunits. Previous work has shown that the final 4 residues of the α4 subunit are required for potentiation. However, receptors conta
Externí odkaz:
https://doaj.org/article/8bbcb75f78884454855084a3adf21122
Publikováno v:
Mol Pharmacol
The two-state coagonist model has been successfully used to analyze and predict peak current responses of the γ-aminobutyric acid type A (GABA(A)) receptor. The goal of the present study was to provide a model-based description of GABA(A) receptor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc44f2849ec9a42ae9fd3299b864fc6f
https://doi.org/10.1124/mol.119.116913
https://doi.org/10.1124/mol.119.116913
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96753 (2014)
Smoking is the leading cause of preventable death worldwide. Accordingly, effort has been devoted to determining the genetic variants that contribute to smoking risk. Genome-wide association studies have identified several variants in nicotinic acety
Externí odkaz:
https://doaj.org/article/f4ae3b361821458286f58909ca1702d5
Autor:
Allison L, Germann, Spencer R, Pierce, Hiroki, Tateiwa, Yusuke, Sugasawa, David E, Reichert, Alex S, Evers, Joe Henry, Steinbach, Gustav, Akk
Publikováno v:
Mol Pharmacol
Prior work employing functional analysis, photolabeling, and X-ray crystallography have identified three distinct binding sites for potentiating steroids in the heteromeric GABA(A) receptor. The sites are located in the membrane-spanning domains of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16f1a21ab66b181274658ce168898929
https://pubmed.ncbi.nlm.nih.gov/33958479
https://pubmed.ncbi.nlm.nih.gov/33958479
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78539 (2013)
In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain. In the muscle nicotinic receptor and other heteromeric members of the f
Externí odkaz:
https://doaj.org/article/c015545da8e345c0b6756450e3c27f23