ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Autor: Zena Wilson, Rajesh Odedra, Yann Wallez, Paul W.G. Wijnhoven, Adina M. Hughes, Joe Gerrard, Gemma N. Jones, Hannah Bargh-Dawson, Elaine Brown, Lucy A. Young, Mark J. O'Connor, Alan Lau

Publikováno v: Cancer Research. 82:1140-1152

AZD6738 (ceralasertib) is a potent and selective orally bioavailable inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR is activated in response to stalled DNA replication forks to promote G2–M cell-cycle checkpoints and fork res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998b1e3ca095cf75db72bb6a3e8ba73b
https://doi.org/10.1158/0008-5472.can-21-2997

Proliferation Tumour Marker Network (PTM-NET) for the identification of tumour region in Ki67 stained breast cancer whole slide images

Autor: Vidalba Rocher Ros, Arvydas Laurinavicius, J. Carl Barrett, Martine P. Roudier, Joe Gerrard, Priya Lakshmi Narayanan, Elizabeth A. Harrington, William J. Howat, Renaldas Augulis, Alison E. Pritchard, Jesuchristopher Joseph

Publikováno v: Scientific Reports
Scientific reports, London : Nature Publishing Group, 2019, vol. 9, art. no. 12845, p. [1-12]
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Uncontrolled proliferation is a hallmark of cancer and can be assessed by labelling breast tissue using immunohistochemistry for Ki67, a protein associated with cell proliferation. Accurate measurement of Ki67-positive tumour nuclei is of critical im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a177f74221d9560678eff45dbd33c1
http://europepmc.org/articles/PMC6731323