ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Autor: Zena Wilson, Rajesh Odedra, Yann Wallez, Paul W.G. Wijnhoven, Adina M. Hughes, Joe Gerrard, Gemma N. Jones, Hannah Bargh-Dawson, Elaine Brown, Lucy A. Young, Mark J. O'Connor, Alan Lau

Publikováno v: Cancer Research. 82:1140-1152

AZD6738 (ceralasertib) is a potent and selective orally bioavailable inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR is activated in response to stalled DNA replication forks to promote G2–M cell-cycle checkpoints and fork res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998b1e3ca095cf75db72bb6a3e8ba73b
https://doi.org/10.1158/0008-5472.can-21-2997

Proliferation Tumour Marker Network (PTM-NET) for the identification of tumour region in Ki67 stained breast cancer whole slide images

Autor: Vidalba Rocher Ros, Arvydas Laurinavicius, J. Carl Barrett, Martine P. Roudier, Joe Gerrard, Priya Lakshmi Narayanan, Elizabeth A. Harrington, William J. Howat, Renaldas Augulis, Alison E. Pritchard, Jesuchristopher Joseph

Publikováno v: Scientific Reports
Scientific reports, London : Nature Publishing Group, 2019, vol. 9, art. no. 12845, p. [1-12]
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Uncontrolled proliferation is a hallmark of cancer and can be assessed by labelling breast tissue using immunohistochemistry for Ki67, a protein associated with cell proliferation. Accurate measurement of Ki67-positive tumour nuclei is of critical im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a177f74221d9560678eff45dbd33c1
http://europepmc.org/articles/PMC6731323

Proliferation Tumour Marker Network (PTM-NET) for the identification of tumour region in Ki67 stained breast cancer whole slide images.

Autor: Joseph, Jesuchristopher¹ jjoseph@coh.org, Roudier, Martine P.¹, Narayanan, Priya Lakshmi², Augulis, Renaldas³, Ros, Vidalba Rocher¹, Pritchard, Alison¹, Gerrard, Joe¹, Laurinavicius, Arvydas³, Harrington, Elizabeth A.¹, Barrett, J. Carl¹, Howat, William J.¹

Publikováno v: Scientific Reports. 9/6/2019, Vol. 9 Issue 1, pN.PAG-N.PAG. 1p.

U.S and European Countries: Overview, Policy and Implications

Autor: Francisca Warner

This book looks at the background of various European countries and their relationship with the United States.

B2B Executive Playbook : The Ultimate Weapon for Achieving Sustainable, Predictable and Profitable Growth

Autor: Sean Geehan

The first book completely focused on successfully running B2B, which is very different from B2C. The fate of a B2B lies in the hands of a few individuals so what ultimately determines if a company thrives, or even survives, is how these key relations