Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joe Gao"'
Autor:
Rogelio Frutos, Thomas G. Tampone, Jason Mulder, Joe Gao, Joshua D. Sieber, Sonia Rodriguez, Nizar Haddad, Katrin Baer, Jack Brown, Bing-Shiou Yang, Riccardo Giovannini, Jinhua J. Song, Nelu Grinberg, Heewon Lee, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 27:505-512
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5417df0fc0c90acc8c027c01343024c7
https://doi.org/10.1021/acs.oprd.2c00373
https://doi.org/10.1021/acs.oprd.2c00373
Autor:
Yanchao Xin, Frank Roschangar, Zeena Williams, Denis Byrne, Dmitry Kurouski, Jason A. Mulder, Jinhua J. Song, Alice T. Granger, Laurence J. Nummy, Jon C. Lorenz, Scott Pennino, Frederic G. Buono, Chris H. Senanayake, Yaping Hong, Ajith Premasiri, Nathan K. Yee, Joe Gao, Sonia Rodriguez, Xinzhu Zhang, Bo Qu, Jack D. Brown, Rogelio P. Frutos, Bikshandarkoil A. Narayanan, Zhantong Mao, Azad Hossain, Ning Li, Mariusz Krawiec, Heewon Lee, Yongda Zhang, Zhengxu S. Han, Nizar Haddad, Zhibin Li, Yibo Xu, Nelu Grinberg, Joshua D. Sieber, Carl A. Busacca
Publikováno v:
The Journal of Organic Chemistry. 83:1448-1461
A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfec6caeeb7cc523f73c8b888a370ad
https://doi.org/10.1021/acs.joc.7b03022
https://doi.org/10.1021/acs.joc.7b03022
Autor:
Zhidong Chen, Carl A. Busacca, Shengli Ma, Xingzhong Zeng, Peter Allen Nemoto, Paige E. Mahaney, Jason A. Mulder, Chris H. Senanayake, Jun Wang, Nitinchandra D. Patel, Zhibin Li, Todd Bosanac, Daniel R. Fandrick, Jean-Nicolas Desrosiers, Heewon Lee, Sonia Rodriguez, Jon C. Lorenz, Nathan K. Yee, Joe Gao, Nelu Grinberg, Hidenori Takahashi, Alessandra Bartolozzi, Jinhua J. Song, Keith R. Fandrick
Publikováno v:
Organic Process Research & Development. 21:1427-1434
A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef81a6daa5f5e0f3f7a2d3016570bad
https://doi.org/10.1021/acs.oprd.7b00202
https://doi.org/10.1021/acs.oprd.7b00202
Autor:
Nelu Grinberg, Jun Wang, Guisheng Li, Jon C. Lorenz, Joe Johnson, Xiufeng Sun, Heewon Lee, Yongda Zhang, Wenjie Li, Joe Gao, Sanjit Sanyal, Zhulin Tan, Nathan K. Yee, Bruce Z. Lu, Keith R. Fandrick, Jiang-Ping Wu, Chris H. Senanayake, Jonathan T. Reeves, Sonia Rodriguez
Publikováno v:
The Journal of Organic Chemistry. 81:2665-2669
An efficient asymmetric synthesis of 11-β-HSD inhibitor 1 has been accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chloro-1-phenylpropan-1-one. The key feature of the synthesis includes an asymmetric me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05ceb16ed339e16e6c600f05b32d8f7
https://doi.org/10.1021/acs.joc.6b00189
https://doi.org/10.1021/acs.joc.6b00189
Autor:
Keith R. Fandrick, Nitinchandra D. Patel, Nelu Grinberg, Heewon Lee, Nathan K. Yee, Shengli Ma, Kanwar Sidhu, Yongda Zhang, Carl A. Busacca, Jason A. Mulder, Jinhua J. Song, Zhibin Li, Joe Gao, Jon C. Lorenz, Melissa A. Herbage, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 20:95-99
A practical and cost-effective synthesis of (2-aminopyrimidin-5-yl) boronic acid 1b has been developed. Key features of the synthesis include the inexpensive in situ protection of the amine via bis-silylation using TMSCl followed by metal–halogen e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5d805db563a9cc896d3437a10d7cdc
https://doi.org/10.1021/acs.oprd.5b00360
https://doi.org/10.1021/acs.oprd.5b00360
Autor:
Joshua D, Sieber, Sonia, Rodriguez, Rogelio, Frutos, Frederic, Buono, Yongda, Zhang, Ning, Li, Bo, Qu, Ajith, Premasiri, Zhibin, Li, Zhengxu S, Han, Yibo, Xu, Denis, Byrne, Nizar, Haddad, Jon, Lorenz, Nelu, Grinberg, Dmitry, Kurouski, Heewon, Lee, Bikshandarkoil, Narayanan, Laurence, Nummy, Jason, Mulder, Jack D, Brown, Alice, Granger, Joe, Gao, Mariusz, Krawiec, Zeena, Williams, Scott, Pennino, Jinhua J, Song, Azad, Hossain, Nathan K, Yee, Carl, Busacca, Frank, Roschangar, Yanchao, Xin, Zhantong, Mao, Xinzhu, Zhang, Yaping, Hong, Chris H, Senanayake
Publikováno v:
The Journal of organic chemistry. 83(3)
A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc8ca7c618df113439501bcd0bd70977
https://pubmed.ncbi.nlm.nih.gov/29323903
https://pubmed.ncbi.nlm.nih.gov/29323903
Autor:
Nelu Grinberg, Marc-André Poupart, Jon C. Lorenz, Bo Qu, Nizar Haddad, Nina C. Gonnella, Shengli Ma, Nathan K. Yee, Wenjun Tang, Jiang-Ping Wu, Youla S. Tsantrizos, Wenjie Li, Joe Gao, Kanwar Sidhu, June Wang, Nitinchandra D. Patel, Sonia Rodriguez, Sanjit Sanyal, Heewon Lee, Yongda Zhang, Carl A. Busacca, Diana C. Reeves, Bruce Z. Lu, Keith R. Fandrick, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 127:7250-7254
A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the BI-DIME ligands for a ligand-controlled Suzuki c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d20ec4749c7a46e4ef82931f7fe303e
https://doi.org/10.1002/ange.201501575
https://doi.org/10.1002/ange.201501575
Autor:
Heewon Lee, Rolf Schmid, Nelu Grinberg, Daniel R. Fandrick, Keith R. Fandrick, Jinhua J. Song, Adil Duran, Shengli Ma, Joe Gao, Elizabeth Archer, Nathan K. Yee, Jason A. Mulder, Juergen Daeubler, Carl A. Busacca, Michael Konrad, Nitinchandra D. Patel, Chris H. Senanayake, Frederic G. Buono
Publikováno v:
Organic Letters. 16:4360-4363
A practical noncryogenic process for the Aggarwal stereospecific boronate rearrangement with chiral secondary benzylic carbamates has been developed. The use of LDA instead of sec-BuLi combined with an in situ trapping of the unstable lithiated carba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932fdb06d1140237f6dd1f929891dd22
https://doi.org/10.1021/ol502060c
https://doi.org/10.1021/ol502060c
Publikováno v:
The Journal of Organic Chemistry. 76:6394-6400
A one-pot process has been developed for the synthesis of 8-arylquinolines via Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura coupling with aryl halides using n-BuPAd(2) as ligand. Yields of up to 98% were obtained.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1daafa38464a198f130131795eb01433
https://doi.org/10.1021/jo200904g
https://doi.org/10.1021/jo200904g
Autor:
Bruce Z. Lu, Keith R. Fandrick, Shengli Ma, Daniel R. Fandrick, Chris H. Senanayake, Wenjie Li, Joe Gao, Jonathan T. Reeves, Heewon Lee, Nelu Grinberg
Publikováno v:
Journal of the American Chemical Society. 133:10332-10335
An operationally simple copper-BINAP-catalyzed, highly enantioselective propargylation of ketones is presented. The methodology was developed as an enantioselective process for methyl ethyl ketone and shown to be applicable to a wide variety of proch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6d62a6f7362e0c167cf5b3e6106633
https://doi.org/10.1021/ja2028958
https://doi.org/10.1021/ja2028958