Zobrazeno 1 - 10
of 752
pro vyhledávání: '"Joe G.N. Garcia"'
Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure
Autor:
Li Gao, Nicholas Rafaels, Tanda M. Dudenkov, Mahendra Damarla, Rachel Damico, James P. Maloney, Marc Moss, Greg S. Martin, Jonathan Sevransky, Carl Shanholtz, Dan L. Herr, Joe G.N. Garcia, Tamara Hernandez-Beeftink, Jesús Villar, Carlos Flores, Terri H. Beaty, Roy Brower, Paul M. Hassoun, Kathleen C. Barnes
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorde
Externí odkaz:
https://doaj.org/article/03c6fd5c4e4d4efd835394c679a13f8b
An eNAMPT-neutralizing mAb reduces post-infarct myocardial fibrosis and left ventricular dysfunction
Autor:
Zhonglin Liu, Saad Sammani, Christy J. Barber, Carrie L. Kempf, Feng Li, Zhen Yang, Rosendo T. Bermudez, Sara M. Camp, Vivian Reyes Herndon, Lars R. Furenlid, Diego R. Martin, Joe G.N. Garcia
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116103- (2024)
Myocardial infarction (MI) triggers adverse ventricular remodeling (VR), cardiac fibrosis, and subsequent heart failure. Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is postulated to play a significant role in VR processing via activ
Externí odkaz:
https://doaj.org/article/753ce422727742c191c8d65e09413c14
Autor:
Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. McKee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G.N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102839- (2023)
p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3
Externí odkaz:
https://doaj.org/article/867adb2a581b43de91087339be330784
Autor:
Heather Lynn, Xiaoguang Sun, Nancy G. Casanova, Christian Bime, Vivian Reyes Hernon, Clayton Lanham, Radu C. Oita, Nikolas Ramos, Belinda Sun, Dawn K. Coletta, Sara M. Camp, Jason H. Karnes, Nathan A. Ellis, Joe G.N. Garcia
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 17 (2023)
Background and objectives: eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target with NAMPT promoter SNPs associated with ARDS severity. This study assesses the previously
Externí odkaz:
https://doaj.org/article/849ab1d49b8642a68a02692ad67fb7cb
Autor:
Joseph B. Mascarenhas, Jin H. Song, Amir A. Gaber, Jeffrey R. Jacobson, Anne E. Cress, Sara M. Camp, Steven M. Dudek, Joe G.N. Garcia
Publikováno v:
Cellular Physiology and Biochemistry, Vol 56, Iss 4, Pp 329-339 (2022)
Externí odkaz:
https://doaj.org/article/db45225a52274a1eb20b98fc2c190c6f
Autor:
Gantsetseg Tumurkhuu, Nancy G. Casanova, Carrie L. Kempf, Duygu Ercan Laguna, Sara M. Camp, Jargalsaikhan Dagvadorj, Jin H. Song, Vivian Reyes Hernon, Cristina Travelli, Erica N. Montano, Jeong Min Yu, Mariko Ishimori, Daniel J. Wallace, Saad Sammani, Caroline Jefferies, Joe G.N. Garcia
Publikováno v:
Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100181- (2023)
Rationale: Effective therapies to reduce the severity and high mortality of pulmonary vasculitis and diffuse alveolar hemorrhage (DAH) in patients with systemic lupus erythematosus (SLE) is a serious unmet need. We explored whether biologic neutraliz
Externí odkaz:
https://doaj.org/article/8b7438a4b64745b39ec0c97c6e32db85
Autor:
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-10 (2021)
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton. The curr
Externí odkaz:
https://doaj.org/article/92ff608ff26f4a6a889aba835f82792f
Autor:
Mohamed Ahmed, Nahla Zaghloul, Prisca Zimmerman, Nancy G. Casanova, Xiaoguang Sun, Jin H. Song, Vivian Reyes Hernon, Saad Sammani, Franz Rischard, Olga Rafikova, Ruslan Rafikov, Ayako Makino, Carrie L. Kempf, Sara M. Camp, Jian Wang, Ankit A. Desai, Yves Lussier, Jason X.‐J. Yuan, Joe G.N. Garcia
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-14 (2021)
Pharmacologic interventions to halt/reverse the vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) remains an unmet need. We previously demonstrated extracellular nicotinamide phosphoribosyltransferase (eNA
Externí odkaz:
https://doaj.org/article/01ea69ffb6ab44d592257d77dde80f26
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102200- (2021)
Externí odkaz:
https://doaj.org/article/5e50ece7ca944aa3ad348ffaf7e166ac
Autor:
Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi, Donna D. Zhang
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101243- (2021)
Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, l
Externí odkaz:
https://doaj.org/article/9b6867c4cff24e0b97a6adf722e6305c