Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Joe G N Garcia"'
Autor:
Mario Paolo Colombo, Joe G N Garcia, Cristina Travelli, Giorgia Colombo, Martina Aliotta, Francesca Fagiani, Natalia Fava, Rita De Sanctis, Ambra A Grolla, Nausicaa Clemente, Paola Portararo, Massimo Costanza, Fabrizio Condorelli, Sabina Sangaletti, Armando A Genazzani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Nicotinamide phosphoribosyltransferase (NAMPT) is a key intracellular enzyme that participates in nicotinamide adenine dinucleotide (NAD) homeostasis as well as a released cytokine (eNAMPT) that is elevated in inflammatory conditions and i
Externí odkaz:
https://doaj.org/article/c682ddf856af461abc7e0fc0260b779f
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226553 (2019)
BACKGROUND:Pulmonary vascular endothelium is the main metabolic site for Angiotensin I-Converting Enzyme (ACE)-mediated degradation of several biologically-active peptides (angiotensin I, bradykinin, hemo-regulatory peptide Ac-SDKP). Primary lung can
Externí odkaz:
https://doaj.org/article/ba6593a7d860446fb6c89ed0f7e6a0dd
Autor:
Sergey Kurdyukov, Cody A Eccles, Ankit A Desai, Manuel Gonzalez-Garay, Jason X-J Yuan, Joe G N Garcia, Olga Rafikova, Ruslan Rafikov
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203493 (2018)
Pulmonary Arterial Hypertension (PAH) is a fatal disorder with limited treatment options and reduced life expectancy after diagnosis. Complex genetic backgrounds in PAH complicates identification of causative mutations that is essential for an unders
Externí odkaz:
https://doaj.org/article/f5cecf18802948468813981919888e37
Autor:
Heather Lynn, Xiaoguang Sun, Djanybek Ayshiev, Jessica H Siegler, Alicia N Rizzo, Jason H Karnes, Manuel Gonzales Garay, Ting Wang, Nancy Casanova, Sara M Camp, Nathan A Ellis, Joe G N Garcia
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200916 (2018)
IntroductionPseudogenes are paralogues of functional genes historically viewed as defunct due to either the lack of regulatory elements or the presence of frameshift mutations. Recent evidence, however, suggests that pseudogenes may regulate gene exp
Externí odkaz:
https://doaj.org/article/b093ed7bd2d94c9699eacf8bf0ffc81b
Autor:
Victoria E Tikhomirova, Olga A Kost, Olga V Kryukova, Elena Z Golukhova, Naida I Bulaeva, Aigerim Z Zholbaeva, Leo A Bokeria, Joe G N Garcia, Sergei M Danilov
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181976 (2017)
Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, is expressed as a type-1 membrane glycoprotein on the surface of different cells, including endothelial ce
Externí odkaz:
https://doaj.org/article/e91827df7fa24e37ae1269f44f4832d7
Autor:
Olga Rafikova, Mary L Meadows, Jason M Kinchen, Robert P Mohney, Emin Maltepe, Ankit A Desai, Jason X-J Yuan, Joe G N Garcia, Jeffrey R Fineman, Ruslan Rafikov, Stephen M Black
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150480 (2016)
There is increasing interest in the potential for metabolic profiling to evaluate the progression of pulmonary hypertension (PH). However, a detailed analysis of the metabolic changes in lungs at the early stage of PH, characterized by increased pulm
Externí odkaz:
https://doaj.org/article/55c5de473c2c4faaa18587933f9f342c
Autor:
Lishi Xie, Eddie T Chiang, Xiaomin Wu, Gabriel T Kelly, Prasad Kanteti, Patrick A Singleton, Sara M Camp, Tingting Zhou, Steven M Dudek, Viswanathan Natarajan, Ting Wang, Steven M Black, Joe G N Garcia, Jeffrey R Jacobson
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158865 (2016)
Protein Kinase C (PKC) plays a significant role in thrombin-induced loss of endothelial cell (EC) barrier integrity; however, the existence of more than 10 isozymes of PKC and tissue-specific isoform expression has limited our understanding of this i
Externí odkaz:
https://doaj.org/article/325f5190215144d989b805659ed1cb10
Autor:
Julio D Duarte, Ankit A Desai, Justin R Sysol, Taimur Abbasi, Amit R Patel, Roberto M Lang, Akash Gupta, Joe G N Garcia, Victor R Gordeuk, Roberto F Machado
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163013 (2016)
Diastolic dysfunction is common in sickle cell disease (SCD), and is associated with an increased risk of mortality. However, the molecular pathogenesis underlying this development is poorly understood. The aim of this study was to identify a gene ex
Externí odkaz:
https://doaj.org/article/4d8849aebbee4a859569a94654b875a0
Autor:
Julia H Indik, Vineet Nair, Ruslan Rafikov, Iwan S Nyotowidjojo, Jaskanwal Bisla, Mayank Kansal, Devang S Parikh, Melissa Robinson, Anand Desai, Megha Oberoi, Akash Gupta, Taimur Abbasi, Zain Khalpey, Amit R Patel, Roberto M Lang, Samuel C Dudley, Bum-Rak Choi, Joe G N Garcia, Roberto F Machado, Ankit A Desai
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164526 (2016)
Sudden death is a leading cause of mortality in sickle cell disease, implicating ventricular tachyarrhythmias. Prolonged QTc on an electrocardiogram (ECG), commonly seen with myocardial ischemia, is a known risk for polymorphic ventricular tachycardi
Externí odkaz:
https://doaj.org/article/9f2a02da94f940d194963dbc14c1f793
Autor:
Kui Shen, Benjamin Ramirez, Brandon Mapes, Grace R Shen, Vijay Gokhale, Mary E Brown, Bernard Santarsiero, Yoshitaka Ishii, Steven M Dudek, Ting Wang, Joe G N Garcia
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130515 (2015)
The MYLK gene encodes the multifunctional enzyme, myosin light chain kinase (MLCK), involved in isoform-specific non-muscle and smooth muscle contraction and regulation of vascular permeability during inflammation. Three MYLK SNPs (P21H, S147P, V261A
Externí odkaz:
https://doaj.org/article/d5b87c310fe84d008d9bb05eb4d63162