Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joe D. Lewis"'
Autor:
Nikolaos Karantzelis, Michalis Petropoulos, Valeria De Marco, David A. Egan, Alexander Fish, Evangelos Christodoulou, David W. Will, Joe D. Lewis, Anastassis Perrakis, Zoi Lygerou, Stavros Taraviras
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replicati
Externí odkaz:
https://doaj.org/article/a12e5a12cb4d47728c4807ff7f7cae4b
Autor:
Jennifer S Carew, Juan A Esquivel, Claudia M Espitia, Christoph M Schultes, Marcel Mülbaier, Joe D Lewis, Bernd Janssen, Francis J Giles, Steffan T Nawrocki
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e31120 (2012)
Hypoxia-inducible factor (HIF) is an attractive therapeutic target for renal cell carcinoma (RCC) as its high expression due to the loss of von Hippel-Lindau (VHL) promotes RCC progression. Considering this, we hypothesized that ELR510444, a novel or
Externí odkaz:
https://doaj.org/article/efc0859661774db09ea52cde675cc4cd
Autor:
Joe D. Lewis, David Tollervey
Publikováno v:
Science. 288:1385-1389
Structures visible within the eukaryotic nucleus have fascinated generations of biologists. Recent data show that these structures form in response to gene expression and are highly dynamic in living cells. RNA processing and assembly require many fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02fd61bc0bca78f037fe772f277f23a
https://doi.org/10.1126/science.288.5470.1385
https://doi.org/10.1126/science.288.5470.1385
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Summary Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d562683e1b6804351b5f4e21c31329
https://doi.org/10.1242/jcs.1992.supplement_16.2
https://doi.org/10.1242/jcs.1992.supplement_16.2
Publikováno v:
Molecular and cellular biology. 21(11)
In eukaryotes the majority of mRNAs have an m(7)G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism. The nuclear cap-binding complex (CBC; consisting of CBP20 and CBP80) mediates the stimulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba43fff57d5b65e6343b43884f6acb50
https://pubmed.ncbi.nlm.nih.gov/11340157
https://pubmed.ncbi.nlm.nih.gov/11340157
Autor:
Elisa Izaurralde, Joe D. Lewis
Publikováno v:
European journal of biochemistry. 247(2)
The cap structure that is characteristic of all polymerase-II-transcribed RNAs has been shown to play an important role in many aspects of RNA metabolism including RNA processing, RNA nuclear transport, and translation initiation. The effects of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcf2975d24253b6e750a66114081d2a
https://pubmed.ncbi.nlm.nih.gov/9266685
https://pubmed.ncbi.nlm.nih.gov/9266685
Publikováno v:
Nucleic acids research. 20(19)
Methylated DNA in vertebrates is associated with transcriptional repression and inactive chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically to DNA containing methyl-CpG pairs. In this report we characterize MeCP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf8220407142dba58a39b48ec88416f
https://pubmed.ncbi.nlm.nih.gov/1408825
https://pubmed.ncbi.nlm.nih.gov/1408825
Autor:
Adrian Bird, Joe D. Lewis
Publikováno v:
FEBS letters. 285(2)
Studies of the whole genome by molecular and cytogenetic methods have implicated DNA methylation in the formation of ‘inactive chromatin’. This has been confirmed by analysis of specific endogenous sequences, and has been mimicked by introducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149f38ff858639e51e598a188e658bf3
https://pubmed.ncbi.nlm.nih.gov/1855583
https://pubmed.ncbi.nlm.nih.gov/1855583
Autor:
Joe D. Lewis
Publikováno v:
Genetical Research. 74:107-108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87bb57dffcb5a0cd7d206e400420c50b
https://doi.org/10.1017/s0016672399219027
https://doi.org/10.1017/s0016672399219027
Publikováno v:
Cell. 58(3)
The effects of DNA methylation on transcription and chromatin structure require that nuclear factors be able to distinguish methylated and nonmethylated DNA. We describe a methyl-CpG binding protein (MeCP) that complexes with a variety of unrelated D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abef4cfb7b982a56a6e1a132dd12e2b0
https://pubmed.ncbi.nlm.nih.gov/2758464
https://pubmed.ncbi.nlm.nih.gov/2758464