Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joe Coyle"'
Autor:
Fearghal Kerin, Stuart O’Flanagan, Joe Coyle, Garreth Farrell, Darragh Curley, Ulrik McCarthy Persson, Giuseppe De Vito, Eamonn Delahunt
Publikováno v:
Sports Medicine - Open, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Hamstring strain injuries (HSI) are one of the most common sport-related injuries. They have a high injury burden and a high recurrence rate. The development of novel muscle injury grading systems has provided new insights into the possible
Externí odkaz:
https://doaj.org/article/7ade4205d28e4effb22c28e309fc93c5
Autor:
Reto Walser, Joe Coyle
Publikováno v:
SLAS Discovery. 25:471-490
Fragment-based drug discovery (FBDD) has come of age in the last decade with the FDA approval of four fragment-derived drugs. Biophysical methods are at the heart of hit discovery and validation in FBDD campaigns. The three most commonly used methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19eb10f30e7e3c4a6e3a1669176f55df
https://doi.org/10.1177/2472555220916168
https://doi.org/10.1177/2472555220916168
Autor:
Joe Coyle, Nilima Nigam
Publikováno v:
Computers & Mathematics with Applications. 72:768-784
In this paper we analyze a discontinuous Galerkin finite element method for approximating solutions to transport equations with certain nonlinearities. We consider models for age-structured populations allowing for a nonlinear removal rate with non-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa9778d75a5438097b1ddd044a077ac
https://doi.org/10.1016/j.camwa.2016.05.024
https://doi.org/10.1016/j.camwa.2016.05.024
Autor:
Joe Coyle, Lee William Page, Dave Clapham, Karen Affleck, Paul N. Mortenson, Jonathan P. Hutchinson, Ashley Paul Hancock, Melanie Leveridge, Joelle Le, Heather Hobbs, David Norton, Rachel McMenamin, Simon Teague, Emma Sherriff, Linda J. Russell, Sorif Uddin, Caroline Richardson, Anne Cleasby, Simon Teanby Hodgson, Philip J. Day, Martyn Frederickson, Gordon Saxty
Publikováno v:
Med. Chem. Commun.. 5:134-141
Using X-ray crystallographic screening, fragments 4 and 6 were identified as inhibitors of hematopoietic prostaglandin D2 synthase (H-PGDS). Both fragments induced a small protein movement in the X-ray crystal structure relative to the apo structure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3850d001e5b02755bbbe21405c11b8
https://doi.org/10.1039/c3md00280b
https://doi.org/10.1039/c3md00280b
Autor:
Joe Coyle
Publikováno v:
Applied Numerical Mathematics. 62:1910-1924
An hp-convergence result is established for an overlapping solution finite element method employed in exterior scattering problems. The method relies on the fundamental solution associated with the background medium. The results include the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b862f75e73b5e9f5d5ebf0ba379682a2
https://doi.org/10.1016/j.apnum.2012.07.005
https://doi.org/10.1016/j.apnum.2012.07.005
Autor:
Joseph Antony, Kieran Moran, Neil Welch, Noel E. O'Connor, Joe Coyle, Kevin McGuinness, Andrew Franklyn-Miller
Publikováno v:
Antony, Joseph ORCID: 0000-0001-6493-7829 , McGuinness, Kevin ORCID: 0000-0003-1336-6477 , Welch, Neil, Coyle, Joe, Franklyn-Miller, Andrew ORCID: 0000-0002-7826-2209 , O'Connor, Noel E. ORCID: 0000-0002-4033-9135 and Moran, Kieran ORCID: 0000-0003-2015-8967 (2015) An interactive segmentation tool for quantifying fat in lumbar muscles using axial lumbar-spine MRI. IRBM, 37 (1). pp. 11-22. ISSN 1959-0318
In this paper we present an interactive tool that can be used to quantify fat infiltration in lumbar muscles, which is useful in studying fat infiltration and lower back pain (LBP) in adults. Currently, a qualitative assessment by visual grading via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705ca6c25ab4c9e546f79f0d9dcd5162
Autor:
Joe Coyle, Tomoko Smyth, Jayne Curry, Nicola G. Wallis, David M. Cross, Ruth Feltell, Isobel Harada, Brent Graham, Matthias Reule, Brian Williams, Hayley Angove, Lynsey Fazal, John Lyons, Neil T. Thompson
Publikováno v:
Cancer Sci
A ubiquitously expressed chaperone, heat shock protein 90 (HSP90) is of considerable interest as an oncology target because tumor cells and oncogenic proteins are acutely dependent on its activity. AT13387 (2,4‐dihydroxy‐5‐isopropyl‐phenyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999a2489c589885299826255d78ec3e
https://doi.org/10.1111/j.1349-7006.2011.02191.x
https://doi.org/10.1111/j.1349-7006.2011.02191.x
Autor:
Joseph A. Eustace, Michael M. Maher, Eva Long, Michael R. Clarkson, Joe Coyle, Sebastian McWilliams, Sinead Kinsella
Publikováno v:
Kidney International. 78(8):789-793
Hemodialysis is associated with an increased risk of neoplasms which may result, at least in part, from exposure to ionizing radiation associated with frequent radiographic procedures. In order to estimate the average radiation exposure of those on h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc5bcf7d509b3fcf3252cd131b400d1
Autor:
Finn P. Holding, Jeff Yon, Rachel McMenamin, Ian J. Tickle, Christoph Lengauer, Harren Jhoti, Anne Cleasby, Philip J. Day, Joe Coyle, Marc O'Reilly, Rajiv Chopra
Publikováno v:
Proceedings of the National Academy of Sciences. 106:4166-4170
The cyclin D1–cyclin-dependent kinase 4 (CDK4) complex is a key regulator of the transition through the G 1 phase of the cell cycle. Among the cyclin/CDKs, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a296ba3972912cbf24a87ee0911f2c1e
https://doi.org/10.1073/pnas.0809645106
https://doi.org/10.1073/pnas.0809645106
Publikováno v:
Emergency Radiology. 16:493-496
With increasing numbers of solid organ and hematopoietic stem cell transplantations being performed, there have been significant increases in the use of immunosuppressive agents such as cyclosporine and tacrolimus. Posterior reversible encephalopathy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa2a0b58bac4df90923a396bc80d656
https://doi.org/10.1007/s10140-008-0782-6
https://doi.org/10.1007/s10140-008-0782-6