Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Joe Conner"'
Autor:
Amy Kwan, Faith Howard, Natalie Winder, Emer Atkinson, Ameera Jailani, Priya B. Patel, Richard Allen, Penelope D. Ottewell, Gary C. Shaw, Joe Conner, Caroline Wilson, Sanjay K. Srivastava, Sarah J. Danson, Claire Lewis, Janet E. Brown, Munitta Muthana
Publikováno v:
Future Pharmacology, Vol 2, Iss 4, Pp 444-459 (2022)
Oncolytic viruses (OV) promote anti-tumour responses through the initiation of immunogenic cancer cell death which activates the host’s systemic anti-tumour immunity. We have previously shown that intravenously administered HSV1716 is an effective
Externí odkaz:
https://doaj.org/article/3b4d26e88bfb46238c249a242f2891a1
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Treatment with HSV1716 via intralesional administration has proven successful for melanoma patients with the hope that oncolytic virotherapy would become another weapon in the systemic anticancer therapy (SACT) arsenal. In addition to challenges surr
Externí odkaz:
https://doaj.org/article/560c5874721e4e2fbbf1d276996d7d44
Autor:
Simon Tazzyman, Georgia R. Stewart, James Yeomans, Adam Linford, Darren Lath, Joe Conner, Munitta Muthana, Andrew D. Chantry, Michelle A. Lawson
Publikováno v:
Viruses, Vol 15, Iss 3, p 603 (2023)
Multiple myeloma remains largely incurable due to refractory disease; therefore, novel treatment strategies that are safe and well-tolerated are required. Here, we studied the modified herpes simplex virus HSV1716 (SEPREHVIR®), which only replicates
Externí odkaz:
https://doaj.org/article/90bd4219e18b434d874154b6a60071e9
Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma
Autor:
Mary Frances Wedekind, Katherine E. Miller, Chun-Yu Chen, Pin-Yi Wang, Brian J. Hutzen, Mark A. Currier, Brooke Nartker, Ryan D. Roberts, Louis Boon, Joe Conner, Stephanie LaHaye, Benjamin J. Kelly, David Gordon, Peter White, Elaine R. Mardis, Timothy P. Cripe
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102759- (2021)
Summary: Osteosarcoma remains one of the deadliest cancers in pediatrics and young adults. We administered two types of immunotherapies, oncolytic virotherapy and immune checkpoint inhibition, to two murine osteosarcoma models and observed divergent
Externí odkaz:
https://doaj.org/article/42684aaa1ef54305b26e4df761b4bd3f
Autor:
Brian Hutzen, Chun-Yu Chen, Pin-Yi Wang, Les Sprague, Hayley M. Swain, Julia Love, Joe Conner, Louis Boon, Timothy P. Cripe
Publikováno v:
Molecular Therapy: Oncolytics, Vol 7, Iss , Pp 17-26 (2017)
Oncolytic viruses are an emerging class of cancer therapeutics that couple cytotoxicity with the induction of an anti-tumor immune response. Host-virus interactions are complex and modulated by a tumor microenvironment whose immunosuppressive activit
Externí odkaz:
https://doaj.org/article/b423665c8cfd4dff87b158ec049baa6f
Autor:
Julia V. Cockle, Anke Brüning-Richardson, Karen J. Scott, Jill Thompson, Timothy Kottke, Ewan Morrison, Azam Ismail, Angel M. Carcaboso, Ailsa Rose, Peter Selby, Joe Conner, Susan Picton, Susan Short, Richard Vile, Alan Melcher, Elizabeth Ilett
Publikováno v:
Molecular Therapy: Oncolytics, Vol 5, Iss C, Pp 75-86 (2017)
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms.
Externí odkaz:
https://doaj.org/article/6daa5830e2af4d63a0235f4c00e305f7
Autor:
Chun-Yu Chen, Pin-Yi Wang, Brian Hutzen, Les Sprague, Hayley M. Swain, Julia K. Love, Joseph R. Stanek, Louis Boon, Joe Conner, Timothy P. Cripe
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promotion of antitumor T cell resp
Externí odkaz:
https://doaj.org/article/fdcd41e11f1d41dba014f2f0f98645df
Autor:
Leslee Sprague, Joel M. Lee, Brian J. Hutzen, Pin-Yi Wang, Chun-Yu Chen, Joe Conner, Lynne Braidwood, Kevin A. Cassady, Timothy P. Cripe
Publikováno v:
Viruses, Vol 10, Iss 3, p 132 (2018)
High Mobility Group Box 1 (HMGB1) is a multifunctional protein that plays various roles in the processes of inflammation, cancer, and other diseases. Many reports document abundant HMGB1 release following infection with oncolytic viruses (OVs). Furth
Externí odkaz:
https://doaj.org/article/49d4150dad95436fb37a92c1e24c853e
Autor:
Munitta Muthana, Joe Conner, Sarah J. Danson, Janet E. Brown, Claire E. Lewis, Graham Pockley, Jayakumar Vadakekolathu, Penelope Ottewell, Sanjay Srivastava, Simon J. Tazzyman, Taewoo Kim, Adam Wilshaw, Joshua Handley, Katie Cox, Drew Capper, Matthew Hutchinson, Dhanajay Evans, Rikah Louie, Mohammed Moamin, Russell Hughes, Richard J. Allen, Haider Al-Janabi, Emer Atkinson, Natalie Winder, Amy Kwan
Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a95db13d525e2373f8c7096de989a19
https://doi.org/10.1158/1535-7163.22521123
https://doi.org/10.1158/1535-7163.22521123
Autor:
Timothy P. Cripe, Joe Conner, Robert Spavin, Kathleen Simpson, Marianne Brunner, Beth Stockman, Lori R. Backus, Devon J. Dishman, Kristy Ott-Napier, Melinda Triplet, Michele R. Vaughan, Alexander J. Towbin, John M. Racadio, Patrick S. Warren, Mark A. Currier, James I. Geller, Keri A. Streby
Purpose: HSV1716 is an oncolytic herpes simplex virus-1 (HSV-1) studied in adults via injection into the brain and superficial tumors. To determine the safety of administering HSV1716 to pediatric patients with cancer, we conducted a phase I trial of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c03d81186256f1fe1e3d21f5dfaed99
https://doi.org/10.1158/1078-0432.c.6526407.v1
https://doi.org/10.1158/1078-0432.c.6526407.v1