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pro vyhledávání: '"Joe Codamo"'
Publikováno v:
Journal of Chemical Technology & Biotechnology. 86:923-934
Background: Transient gene expression (TGE) provides a rapid way to generate recombinant protein biologics for pre-clinical assessment. Human embryonic kidney (HEK293) cells have traditionally been used for TGE; however, there is demand from industry
Autor:
Joe Codamo, Trent P. Munro, Warren Pilbrough, Benjamin S. Hughes, Jeff Jia Cheng Hou, Peter P. Gray
Publikováno v:
Journal of Chemical Technology & Biotechnology. 86:895-904
Worldwide sales of biologic drugs exceeded US$ 92 billion in 2009. With many biopharmaceutical patents expiring over the next decade, a wave of second-generation or ‘follow-on’ biologics will be vying for market share and regulatory approval. Pat
Publikováno v:
Biotechnology and bioengineering. 99(3)
The success of engineered monoclonal antibodies as biopharmaceuticals has generated considerable interest in strategies designed to accelerate development of antibody expressing cell lines. Stable mammalian cell lines that express therapeutic antibod