Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Joe Chiba"'
Autor:
Takayuki Matsumura, Ayae Nishiyama, Michio Aiko, Akira Ainai, Tadayoshi Ikebe, Joe Chiba, Manabu Ato, Yoshimasa Takahashi
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
Abstract Objective Streptococcus pyogenes (Group A Streptococcus; GAS) causes a variety of infections that include life-threatening, severe invasive GAS infections, such as streptococcal toxic shock syndrome (STSS), with > 30% mortality rate, despite
Externí odkaz:
https://doaj.org/article/935c46cd0cec48e7a2b0b852383ff4d8
Autor:
Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) can cross-link RP105 on B cells, resulting in th
Externí odkaz:
https://doaj.org/article/349c2f98b4804ec392860fc398516433
Publikováno v:
Bio-Protocol, Vol 9, Iss 4 (2019)
Membrane proteins such as cytokine receptors and G protein-coupled receptors can be drug targets. Recently, we have generated specific monoclonal antibodies (mAbs) against the mouse IL-9 receptor (IL-9R) and found that IL-9R on memory B cells have cr
Externí odkaz:
https://doaj.org/article/ebb6139c7042438c88faedbecccd7c3f
Publikováno v:
Vaccines, Vol 8, Iss 3, p 424 (2020)
Influenza viruses cause annual epidemics and occasional pandemics. The high diversity of viral envelope proteins permits viruses to escape host immunity. Therefore, the development of a universal vaccine and broadly neutralizing antibodies (bnAbs) is
Externí odkaz:
https://doaj.org/article/3fa276fa3a3542ebb9c1c281a18d782a
Autor:
Tatsuya Yamazaki, Maria Nagashima, Daisuke Ninomiya, Akira Ainai, Akira Fujimoto, Isao Ichimonji, Hidekazu Takagi, Naoko Morita, Kenta Murotani, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The influenza virus causes annual epidemics and occasional pandemics and is thus a major public health problem. Development of vaccines and antiviral drugs is essential for controlling influenza virus infection. We previously demonstrated the use of
Externí odkaz:
https://doaj.org/article/cc6286f4ff2b4546ae803b10aebf7e4d
Publikováno v:
Vaccines, Vol 6, Iss 3, p 35 (2018)
Hemagglutinin (HA) of influenza virus is a major target for vaccines. HA initiates the internalization of the virus into the host cell by binding to host sialic acid receptors; therefore, inhibition of HA can significantly prevent influenza virus inf
Externí odkaz:
https://doaj.org/article/73299d38a34441b6852465b72ceb1276
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30351 (2012)
While Wiskott-Aldrich syndrome protein (WASP) plays critical roles in TCR signaling as an adaptor molecule, how it transduces innate immune signals remains to be elucidated. To investigate the roles of WASP in innate immune cells, we established bone
Externí odkaz:
https://doaj.org/article/2deba24bb6884608bfde6e6485764c88
Autor:
Yoshinari Ando, Yasuhiro Tomaru, Ayako Morinaga, Alexander Maxwell Burroughs, Hideya Kawaji, Atsutaka Kubosaki, Ryuichiro Kimura, Maiko Tagata, Yoko Ino, Hisashi Hirano, Joe Chiba, Harukazu Suzuki, Piero Carninci, Yoshihide Hayashizaki
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23385 (2011)
Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not
Externí odkaz:
https://doaj.org/article/803b6e1077a941528d8bba48166c136b
Autor:
Sachiko Akashi-Takamura, Joe Chiba, Hideki Hasegawa, Susumu Tomono, Fumiaki Nagaoka, Mrityunjoy Biswas, Akira Ainai, Masanori Inui, Isao Ichimonji, Maria Nagashima, Tatsuya Yamazaki, Hidekazu Takagi, Kouyu Kosugi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) can cross-link RP105 on B cells, resulting in th
Publikováno v:
Vaccines
Vaccines, Vol 8, Iss 424, p 424 (2020)
Vaccines, Vol 8, Iss 424, p 424 (2020)
Influenza viruses cause annual epidemics and occasional pandemics. The high diversity of viral envelope proteins permits viruses to escape host immunity. Therefore, the development of a universal vaccine and broadly neutralizing antibodies (bnAbs) is