Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joe C, Udeochu"'
Autor:
Joe C. Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S. Torres, Gillian K. Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T. Gill, Ravikiran M. Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E. Tracy, Rajiv R. Ratan, Li-Huei Tsai, Subhash C. Sinha, Li Gan
Publikováno v:
Nature Neuroscience. 26:737-750
Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP–AMP synthase (cGAS) diminishes cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09f63c16301d932a0b75e214f4703692
https://doi.org/10.1038/s41593-023-01315-6
https://doi.org/10.1038/s41593-023-01315-6
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Yungui Zhou, Shiaoching Gong, John Hardy, Qingyun Li, Linas Mazutis, Li Fan, Yue Qiu, Pearly Ye, Dennis W. Dickson, Tara E. Tracy, Xiang Niu, Lay Kodama, Michael DeTure, Bin Zhang, Subhash C. Sinha, Wenjie Luo, Xueting Wang, Xueqiao Jiang, Lei Xie, Guoqiang Yu, Fei Wang, Li Gan, Zuolin Cheng, Georgia R. Frost, Maria Telpoukhovskaia, Rose Horowitz, John Q. Trajnowski, Man Ying Wong, Fuying Gao, Giovanni Coppola, Yaqiao Li, Virginia M.-Y. Lee, Faten A. Sayed, Lu Zhou, Hansruedi Mathys, Joe C. Udeochu, David Le, Gillian K. Carling, Matthew Brendel, Minghui Wang
Publikováno v:
Sci Transl Med
The hemizygous R47H variant of Triggering receptor expressed on myeloid cells 2 (TREM2), a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). Using transcriptomic analysis of single-nuclei from brain tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bfaa5135ff0c66a29779f068ec0946
https://doi.org/10.1126/scitranslmed.abe3947
https://doi.org/10.1126/scitranslmed.abe3947
Autor:
Nina M, Dräger, Sydney M, Sattler, Cindy Tzu-Ling, Huang, Olivia M, Teter, Kun, Leng, Sayed Hadi, Hashemi, Jason, Hong, Giovanni, Aviles, Claire D, Clelland, Lihong, Zhan, Joe C, Udeochu, Lay, Kodama, Andrew B, Singleton, Mike A, Nalls, Justin, Ichida, Michael E, Ward, Faraz, Faghri, Li, Gan, Martin, Kampmann
Publikováno v:
Nature neuroscience. 25(9)
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2d21f95b47547b29ccf967a5ceb7717
https://pubmed.ncbi.nlm.nih.gov/35953545
https://pubmed.ncbi.nlm.nih.gov/35953545
Autor:
Hansruedi Mathys, Yue Qiu, Joe C. Udeochu, David Le, Lei Xie, Linas Mazutis, Xueting Wang, Michael DeTure, Georgia R. Frost, Gillian K. Carling, John Hardy, Li Fan, Wenjie Luo, Li Gan, Zuolin Cheng, Lay Kodama, Fei Wang, Giovanni Coppola, Maria Telpoukhovskaia, Man Ying Wong, Fuying Gao, Minghui Wang, Matthew Brendel, Guoqiang Yu, Tara E. Tracy, Xiang Niu, Bin Zhang, Yaqiao Li, Faten A. Sayed, Dennis W. Dickson, Yungui Zhou, Lu Zhou, Xueqiao Jiang, Shiaoching Gong, Qingyun Li
The hemizygous R47H variant ofTREM2, a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). In this study, we identified a subpopulation of microglia with disease-enhancing proinflammatory signatures associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0aaf393e58f3fa98f504068eff9eae7
https://doi.org/10.1101/2020.07.24.218719
https://doi.org/10.1101/2020.07.24.218719
Publikováno v:
Clinical & Experimental Neuroimmunology
Aging alters the functional integrity of the adult brain, driving cognitive impairments and susceptibility to neurodegenerative disorders in healthy individuals. In fact, aging remains the most dominant risk factor for Alzheimer's disease (AD). Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a451626f1cffe309ef2c297e65304c0e
https://doi.org/10.1111/cen3.12307
https://doi.org/10.1111/cen3.12307
Autor:
Li Gan, Yungui Zhou, Tara E. Tracy, Xiang Niu, Hansruedi Mathys, Li-Huei Tsai, Xueqiao Jiang, David Le, Giovanni Coppola, Maria Telpoukhovskaia, Joe C. Udeochu, Yue-Ming Li, Lay Kodama, Fuying Gao, Georgia R. Frost, Yaqiao Li, Faten A. Sayed, Linas Mazutis, John Hardy
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b150fe327d570696e5a909a4dbd09b
https://doi.org/10.2139/ssrn.3420370
https://doi.org/10.2139/ssrn.3420370
Autor:
Joe C. Udeochu, Yungui Zhou, Qingyun Li, David Le, Kenneth S. Kosik, Li Gan, Lu Zhou, Guoqiang Yu, Lihong Zhan, Yaqiao Li, Faten A. Sayed, Claire D. Clelland, Jon Iker Etchegaray, Elmer Guzman, Zuolin Cheng, Lay Kodama
Publikováno v:
Nature neuroscience
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baade15bf2e93db65900ae8815be634e
https://pubmed.ncbi.nlm.nih.gov/31873194
https://pubmed.ncbi.nlm.nih.gov/31873194
Proper regulation of inflammatory responses is critical for effective function of microglia, in both physiological and disease states. While the mechanisms that drive microglia activation are well characterized, the pathways leading to inflammatory r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1374f624a5dc10cbcf4b6c42077003f
https://doi.org/10.1101/423558
https://doi.org/10.1101/423558
Autor:
Griselda M. Yvone, Megumi Hirose-Ikeda, Austin Wang, Carmine L. Chavez‐Martinez, Joe C. Udeochu, Patricia E. Phelps, Hannah H. Zhao-Fleming
Publikováno v:
The European journal of neuroscience. 45(5)
The Reelin-signaling pathway is essential for correct neuronal positioning within the central nervous system. Mutant mice with a deletion of Reelin, its lipoprotein receptors, or its intracellular adaptor protein Disabled-1 (Dab1), exhibit nociceptiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12bb0e37cc853029ea8665630822aa2
https://pubmed.ncbi.nlm.nih.gov/28083884
https://pubmed.ncbi.nlm.nih.gov/28083884