Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Joe Bentz"'
Autor:
Annie Albin Lumen, Libin Li, Jiben Li, Zeba Ahmed, Zhou Meng, Albert Owen, Harma Ellens, Ismael J Hidalgo, Joe Bentz
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69394 (2013)
We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of that allowed by digoxin passive permeability (as measured in the presence of GF120918) to achieve the observed efflux kinetics across MDCK-
Externí odkaz:
https://doaj.org/article/14700a32b0ad4e079adfa32cc63b0b32
Autor:
Deep Agnani, Poulomi Acharya, Esteban Martinez, Thuy Thanh Tran, Feby Abraham, Frank Tobin, Harma Ellens, Joe Bentz
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25086 (2011)
P-glycoprotein, a human multidrug resistance transporter, has been extensively studied due to its importance to human health and disease. In order to understand transport kinetics via P-gp, confluent cell monolayers overexpressing P-gp are widely use
Externí odkaz:
https://doaj.org/article/47857b4ef5ac49acabc1af6846470038
Autor:
Joe, Bentz, Harma, Ellens
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
In the first edition of this book, we presented the basics of explicitly incorporating the lipid biochemistry into a confluent cell monolayer transport model and the novel findings of this model up to 2013, including the use of global optimization to
Autor:
Joe Bentz
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071612491
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d31f1d17b36c0bebb3eacf1279fe995
https://doi.org/10.1007/978-1-0716-1250-7_2
https://doi.org/10.1007/978-1-0716-1250-7_2
Autor:
Joe Bentz, Harma Ellens
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
In the first edition of this book, we presented the basics of explicitly incorporating the lipid biochemistry into a confluent cell monolayer transport model and the novel findings of this model up to 2013, including the use of global optimization to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf941b1bec2f1dec263ca450a1220ce
https://doi.org/10.1007/978-1-0716-1554-6_27
https://doi.org/10.1007/978-1-0716-1554-6_27
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 14:571-584
In vitro transporter kinetics are typically analyzed by steady-state Michaelis-Menten approximations. However, no clear evidence exists that these approximations, applied to multiple transporters in biological membranes, yield system-independent mech
Autor:
Git Chung, Colin D.A. Brown, Joe Bentz, Akshata Yalvigi, Caroline Lee, Michael O'Connor, Adam Lynn, Harma Ellens, Aqsaa Chaudhry
Publikováno v:
Drug Metabolism and Disposition. 46:279-290
It has been previously demonstrated that IC50 values for inhibition of digoxin transport across confluent polarized cell monolayers are system-dependent. Digoxin IC50 data from five laboratories participating in the P-glycoprotein (P-gp) IC50 Initiat
Publikováno v:
Drug Metabolism and Disposition. 45:145-151
From fits of drug transport kinetics across confluent MDCKII-hMDR1-NKI and Caco-2 cell monolayers we estimated the levels of efflux active P-glycoprotein (P-gp) in these two cell lines (companion paper). In the present work, we compared the efflux ac
Autor:
Nejat Düzgüneş, Joe Bentz
Publikováno v:
Spectroscopic Membrane Probes ISBN: 9781351076807
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2711d08f6c5b62495cfb053a35d8eb63
https://doi.org/10.1201/9781351076807-6
https://doi.org/10.1201/9781351076807-6
Autor:
Aqsaa, Chaudhry, Git, Chung, Adam, Lynn, Akshata, Yalvigi, Colin, Brown, Harma, Ellens, Michael, O'Connor, Caroline, Lee, Joe, Bentz
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(3)
It has been previously demonstrated that IC