Výsledky vyhledávání - "Joe A. Potter"

Akademický článek

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Autor: Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires, Claire E. Hills

Publikováno v: Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)

Abstract Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine

Externí odkaz: https://doaj.org/article/cbf3b5a17eb140fdbcaac434c1479c5c

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Connexin‐mediated cell communication in the kidney: A potential therapeutic target for future intervention of diabetic kidney disease?

Autor: Bethany M Williams, Gareth Price, Paul E. Squires, Joe A. Potter, Chelsy L. Cliff, Claire E. Hills

Publikováno v: Experimental Physiology. 105:219-229

The ability of cells to communicate and synchronise their activity is essential for the maintenance of tissue structure, integrity and function. A family of membrane-bound proteins called connexins are largely responsible for mediating the local tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86519122dca8563e9c3a2afb72275b4
https://doi.org/10.1113/ep087770

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Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

Autor: Claire E. Hills, Gareth Price, Joe A. Potter, Colin R. Green, Paul E. Squires, Chelsy L. Cliff

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3644, p 3644 (2021)

Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP). Kidney fibrosis develops in response to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee94ad6d48bb11507f20c6f40aff9ed
http://europepmc.org/articles/PMC8038016

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Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells

Autor: Chelsy L. Cliff, Gareth Price, Paul E. Squires, Claire E. Hills, Bethany M Williams, Joe A. Potter

Publikováno v: Bio Protoc

Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels. When neighbouring channels align, they form gap-junctions that prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b275a803e8cd96980c0c3d0c42b33bb0
https://doi.org/10.21769/bioprotoc.3901

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Examining Local Cell-to-Cell Signalling in the Kidney Using ATP Biosensing

Autor: Gareth W, Price, Joe A, Potter, Bethany M, Williams, Chelsy L, Cliff, Mark J, Wall, Claire E, Hills, Paul E, Squires

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2346

Cell-to-cell communication is an essential process for the efficient function of cells and tissues. Central to this is the purinergic transmission of purines, with ligands such as adenosine triphosphate (ATP). Altered cell-to-cell communication, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eac8ba71d485ae39fcd1366b252ab81e
https://pubmed.ncbi.nlm.nih.gov/32661915

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Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Autor: Claire E. Hills, Wai Han Yiu, Gareth Price, Colin R. Green, Christos E. Chadjichristos, Joe A. Potter, Eleftherios Siamantouras, Sydney C.W. Tang, Panagiotis Kavvadas, Paul E. Squires

Publikováno v: Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)
Cell Communication and Signaling
Cell Communication and Signaling, BioMed Central, 2020, 18 (1), pp.79. ⟨10.1186/s12964-020-00558-1⟩

Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe13882cb5a152cf3cdbc758fabea8ab
http://europepmc.org/articles/PMC7249671

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Examining Local Cell-to-Cell Signalling in the Kidney Using ATP Biosensing

Autor: Claire E. Hills, Gareth Price, Paul E. Squires, Bethany M Williams, Mark J. Wall, Chelsy L. Cliff, Joe A. Potter

Publikováno v: Methods in Molecular Biology ISBN: 9781071615690

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb5ccf49289f58140d090b0243ffbc98
https://doi.org/10.1007/7651_2020_297

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Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney

Autor: Eleftherios Siamantouras, Paul E. Squires, Gareth Price, Joe A. Potter, Claire E. Hills

Loss of epithelial (E)-cadherin mediated cell-cell adhesion impairs gap junction formation and facilitates hemichannel-mediated ATP release in the diabetic kidney. Linked to inflammation and fibrosis, we hypothesized that local increases in inter-cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed60392f6011cdea000cc55e1636e61
https://eprints.lincoln.ac.uk/id/eprint/38091/1/Nanomedicine.pdf

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Danegaptide Prevents TGFβ1-Induced Damage in Human Proximal Tubule Epithelial Cells of the Kidney

Autor: Claire E. Hills, Gareth Price, Bethany M Williams, Paul E. Squires, Ulrik Mouritzen, Joe A. Potter

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2809, p 2809 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6

Chronic kidney disease (CKD) is a global health problem associated with a number of comorbidities. Recent evidence implicates increased hemichannel-mediated release of adenosine triphosphate (ATP) in the progression of tubulointerstitial fibrosis, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99493cad70d27df910c4542b5d3697dc
https://doi.org/10.3390/ijms22062809

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