Danegaptide Prevents TGFβ1-Induced Damage in Human Proximal Tubule Epithelial Cells of the Kidney

Autor: Paul E. Squires, Gareth W. Price, Ulrik Mouritzen, Joe A. Potter, Bethany M. Williams, Claire E. Hills

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6, p 2809 (2021)

Chronic kidney disease (CKD) is a global health problem associated with a number of comorbidities. Recent evidence implicates increased hemichannel-mediated release of adenosine triphosphate (ATP) in the progression of tubulointerstitial fibrosis, th

Externí odkaz: https://doaj.org/article/8e95d8a526234043bb974ca2ff600f5f

Connexin‐mediated cell communication in the kidney: A potential therapeutic target for future intervention of diabetic kidney disease?

Autor: Bethany M Williams, Gareth Price, Paul E. Squires, Joe A. Potter, Chelsy L. Cliff, Claire E. Hills

Publikováno v: Experimental Physiology. 105:219-229

The ability of cells to communicate and synchronise their activity is essential for the maintenance of tissue structure, integrity and function. A family of membrane-bound proteins called connexins are largely responsible for mediating the local tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86519122dca8563e9c3a2afb72275b4
https://doi.org/10.1113/ep087770

Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells

Autor: Chelsy L. Cliff, Gareth Price, Paul E. Squires, Claire E. Hills, Bethany M Williams, Joe A. Potter

Publikováno v: Bio Protoc

Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels. When neighbouring channels align, they form gap-junctions that prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b275a803e8cd96980c0c3d0c42b33bb0
https://doi.org/10.21769/bioprotoc.3901

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Autor: Claire E. Hills, Wai Han Yiu, Gareth Price, Colin R. Green, Christos E. Chadjichristos, Joe A. Potter, Eleftherios Siamantouras, Sydney C.W. Tang, Panagiotis Kavvadas, Paul E. Squires

Publikováno v: Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)
Cell Communication and Signaling
Cell Communication and Signaling, BioMed Central, 2020, 18 (1), pp.79. ⟨10.1186/s12964-020-00558-1⟩

Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe13882cb5a152cf3cdbc758fabea8ab
http://europepmc.org/articles/PMC7249671

Purinergic receptor (P2X7) activation reduces cell–cell adhesion between tubular epithelial cells of the proximal kidney

Autor: Eleftherios Siamantouras, Paul E. Squires, Gareth Price, Joe A. Potter, Claire E. Hills

Loss of epithelial (E)-cadherin mediated cell-cell adhesion impairs gap junction formation and facilitates hemichannel-mediated ATP release in the diabetic kidney. Linked to inflammation and fibrosis, we hypothesized that local increases in inter-cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed60392f6011cdea000cc55e1636e61
https://eprints.lincoln.ac.uk/id/eprint/38091/1/Nanomedicine.pdf