Descriptive comparison of admission characteristics between pandemic waves and multivariable analysis of the association of the Alpha variant (B.1.1.7 lineage) of SARS-CoV-2 with disease severity in inner London

Autor: Keith Morris, Judith Breuer, NgeeKeong Tan, Eric Witele, Sophie Hunter, Monica Panca, Aleks Marek, Paul Flowers, Gaia Nebbia, Sam Haldenby, Jacqui Prieto, Gee Yen Shin, Fiona Mapp, Andrew Copas, Mark Hopkins, Oliver Stirrup, Adam Witney, Kenneth Laing, May Rabuya, Vasa Curcin, Alison Holmes, Mohammad Raza, Wenjuan Wang, Rachel Williams, David Robertson, Julie Samuel, Rory Gunson, Helen Wheeler, Alexander J Keeley, Paul Randell, Cariad Evans, Tabassum Khan, Michelle Ramsay, Darren Smith, James Price, Sarah Francis, Shazaad Ahmad, Finola Higgins, Eleni Nastouli, Abhinav Kumar, Katie Johnson, Sharon Glaysher, Scott Elliott, Rebecca Gregory, Matthew D Parker, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Anna Riddell, Yanzhong Wang, David Harrington, Alexandra Bailey, Nikunj Mahida, Charlotte Williams, Tanzina Haque, David G Partridge, Yusri Taha, Adrienn Angyal, Catherine Houlihan, James Shepherd, Hayley Colton, Chris Davis, Adela Alcolea-Medina, Themoula Charalampous, Beatrix Kele, Irene Monahan, Guy Mollett, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Luke Snell, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Rahul Batra, Jennifer Hart, Nadua Bayzid, Marius Cotic, Luke Green, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Kate Cook, Katie Loveson, Buddhini Samaraweera, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Dan Frampton, Matt Byott, Judith Heaney, Ana da Silva Filipe, Thushan de Silva, Jonathan Edgeworth, Luke B Snell, Leonardo de Jongh, Teresa Cutino-Moguel, Raghavendran Kulasegaran-Shylini, Claire E. Broad, Dola Owoyemi, Clare Coffey, Martina Cummins, Tyrra D’Souza, Emily Goldstein, Emilie Shepherd, Katherine Smollett, Alice Broos, Stephen Carmichael, Nicholas Suarez, Sreenu Vattipally, Ioulia Tsatsani, Jacqueline McTaggart, Stephanie McEnhill, Adela Medina, Jörg Saßmannshausen, Sulekha Gurung, Anu Augustine, Sid Mookerjee, Krystal Johnson, Thilipan Thaventhiran, Damien Mine, Isa Ahmad, Anitha Ramanathan, Anu Chawla, Alistair Derby, Becky Taylor, Charles Numbere, Jenifer Mason, Nicholas Machin, Julie Cawthorne, Ryan George, James Montgomery, Deborah McKew, Angela Cobb, Maria Leader, Shirelle Burton-Fanning, Lydia Taylor, Matthew Bashton, Matthew Crown, Matthew Loose, Patrick McClure, Mitch Clarke, Elaine Baxter, Carl Yates, Irfan Aslam, Vicki Fleming, Michelle Lister, Johnny Debebe, Nadine Holmes, Christopher Moore, Matt Carlile, Dianne Irish-Tavares, Mia De Mesa, Vicky Pang, Jelena Heaphy, Wendy Chatterton, Monika Pusok, Tranprit Saluja, Zahira Maqsood, Angie Williams, Debbie Devonport, Lucy Palinkas, Diane Thomlinson, Julie Booth, Ashok Dadrah, Amanda Symonds, Cassandra Craig, Benjamin B Lindsey, Benjamin H Foulkes, Stavroula F Louka, Phillip Ravencroft, Sharon Hsu, Nasar Ali, Rasha Raghei, Samantha E Hansford, Hailey R Hornsby, Phil Wade, Kay Cawthron, Maqsood Khan, Amber Ford, Imogen Wilson, Kate Harrington, Nic Tinker, Sally Nyinza, Adhyana Mahanama, Siona Silviera, Christopher Fearn, Claudia Cardosa Pereira, Vaz Malik, Gema Martinez-Garcia, Leila Hail, Ndifreke Atang, Helen Francis, Milica Rajkov, Rachel McComish, Alyson MacNeil, Alif Tamuri, Stefan Piatek

Publikováno v: BMJ Open, Vol 12, Iss 2 (2022)

Externí odkaz: https://doaj.org/article/efa958592ac94093b98169f05e020ab3

Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections

Autor: Matthew D, Parker, Hazel, Stewart, Ola M, Shehata, Benjamin B, Lindsey, Dhruv R, Shah, Sharon, Hsu, Alexander J, Keeley, David G, Partridge, Shay, Leary, Alison, Cope, Amy, State, Katie, Johnson, Nasar, Ali, Rasha, Raghei, Joe, Heffer, Nikki, Smith, Peijun, Zhang, Marta, Gallis, Stavroula F, Louka, Hailey R, Hornsby, Hatoon, Alamri, Max, Whiteley, Benjamin H, Foulkes, Stella, Christou, Paige, Wolverson, Manoj, Pohare, Samantha E, Hansford, Luke R, Green, Cariad, Evans, Mohammad, Raza, Dennis, Wang, Andrew E, Firth, James R, Edgar, Silvana, Gaudieri, Simon, Mallal, Mark O, Collins, Andrew A, Peden, Thushan I, de Silva

Publikováno v: Communications biology. 5(1)

B.1.1.7 lineage SARS-CoV-2 is more transmissible, leads to greater clinical severity, and results in modest reductions in antibody neutralization. Subgenomic RNA (sgRNA) is produced by discontinuous transcription of the SARS-CoV-2 genome. Applying ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c22d549c0e0051e440ab2365c7758aa
https://pubmed.ncbi.nlm.nih.gov/35790808

periscope: sub-genomic RNA identification in SARS-CoV-2 Genomic Sequencing Data

Autor: Lily Tong, Elihu Aranday-Cortes, Chris Davis, Danielle C. Groves, Abha Chopra, Laura Carrilero, David G Partridge, Simon B. Mallal, Dennis Wang, James Shepherd, E. Thomson, Joe Heffer, Jenna Nichols, Matthew Wyles, T.I. de Silva, Shay Leary, Alexander J Keeley, Luke R. Green, Mohammad Raza, Cariad Evans, Sahan Bennett, Alain Kohl, Nikki Smith, Benjamin B Lindsey, Rachel Tucker, Parker, Karen C. Johnson, Ana da Silva Filipe, Paul J. Parsons, Adrienn Angyal, Silvana Gaudieri, Rebecca Brown

Publikováno v: bioRxiv

We have developed periscope, a tool for the detection and quantification of sub-genomic RNA (sgRNA) in SARS-CoV-2 genomic sequence data. The translation of the SARS-CoV-2 RNA genome for most open reading frames (ORFs) occurs via RNA intermediates ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276be4aa8787e37094fb7ec76f3bf0f3
https://doi.org/10.1101/2020.07.01.181867