Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.

Autor: Blanca E Himes, Keith Sheppard, Annerose Berndt, Adriana S Leme, Rachel A Myers, Christopher R Gignoux, Albert M Levin, W James Gauderman, James J Yang, Rasika A Mathias, Isabelle Romieu, Dara G Torgerson, Lindsey A Roth, Scott Huntsman, Celeste Eng, Barbara Klanderman, John Ziniti, Jody Senter-Sylvia, Stanley J Szefler, Robert F Lemanske, Robert S Zeiger, Robert C Strunk, Fernando D Martinez, Homer Boushey, Vernon M Chinchilli, Elliot Israel, David Mauger, Gerard H Koppelman, Dirkje S Postma, Maartje A E Nieuwenhuis, Judith M Vonk, John J Lima, Charles G Irvin, Stephen P Peters, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Augusto A Litonjua, Kelan G Tantisira, Benjamin A Raby, Eugene R Bleecker, Deborah A Meyers, Stephanie J London, Kathleen C Barnes, Frank D Gilliland, L Keoki Williams, Esteban G Burchard, Dan L Nicolae, Carole Ober, Dawn L DeMeo, Edwin K Silverman, Beverly Paigen, Gary Churchill, Steve D Shapiro, Scott T Weiss

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56179 (2013)

Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-

Externí odkaz: https://doaj.org/article/b7148e73eae544b695d4b1d016395c4e

Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women

Autor: COPDGene, Josée Dupuis, Dawn L. DeMeo, George T. O'Connor, Peter J. Castaldi, Merry-Lynn McDonald, Edwin K. Silverman, Terri H. Beaty, Megan Hardin, Michael H. Cho, Kimberly Glass, Scott T. Weiss, Jody Senter-Sylvia, Kelan G. Tantisira, Jarrett D. Morrow, David A. Lomas, Hugues Aschard, Alvar Agusti, John E. Hokanson, James D. Crapo, Amund Gulsvik, Sunita Sharma, Per Bakke, Nan M. Laird, Craig P. Hersh

Publikováno v: American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2017, 56 (3), pp.332-341. ⟨10.1165/rcmb.2016-0172OC⟩
American journal of respiratory cell and molecular biology, vol 56, iss 3

International audience; Chronic obstructive pulmonary disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the herit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8786e97925ca9f9db6e957dec0e737
https://hal-pasteur.archives-ouvertes.fr/pasteur-03278723

Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes

Autor: Vincent J. Carey, Andrew H. Liu, Amy Murphy, Tomi Pastinen, Jody Senter-Sylvia, John Ziniti, Becky M. Vonakis, Christoph Lange, Karen DeMuth, Stanley J. Szefler, Ross Lazarus, Mario Castro, N. Franklin Adkinson, Nadia N. Hansel, Jen-Hwa Chu, Gregory B. Diette, Robert C. Strunk, Mousheng Xu, Benjamin A. Raby, Barbara J. Klanderman

Publikováno v: Human Molecular Genetics. 19:4745-4757

Genome-wide association studies of human gene expression promise to identify functional regulatory genetic variation that contributes to phenotypic diversity. However, it is unclear how useful this approach will be for the identification of disease-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4bd647b2c2e271e6e4468a7dd5875a
https://doi.org/10.1093/hmg/ddq392

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene

Autor: Scott T. Weiss, Steve D. Shapiro, Annerose Berndt, W. James Gauderman, Jody Senter-Sylvia, Rachel A. Myers, Mayumi Tamari, Dan L. Nicolae, Robert S. Zeiger, Stephen P. Peters, John Ziniti, Benjamin A. Raby, Lindsey A. Roth, James J. Yang, Charles G. Irvin, Barbara J. Klanderman, Isabelle Romieu, John J. Lima, Maartje A.E. Nieuwenhuis, Kelan G. Tantisira, Michiaki Kubo, Judith M. Vonk, Fernando D. Martinez, Dara G. Torgerson, Christopher R. Gignoux, Beverly Paigen, Homer A. Boushey, Carole Ober, Stephanie J. London, Elliot Israel, Keith Sheppard, Eugene R. Bleecker, Blanca E. Himes, Edwin K. Silverman, Esteban G. Burchard, Kathleen C. Barnes, Frank D. Gilliland, Albert M. Levin, Gary A. Churchill, David T. Mauger, Dawn L. DeMeo, Scott Huntsman, Stanley J. Szefler, Augusto A. Litonjua, Vernon M. Chinchilli, Robert C. Strunk, Celeste Eng, L. Keoki Williams, Deborah A. Meyers, Yusuke Nakamura, Robert F. Lemanske, Gerard H. Koppelman, Adriana S. Leme, Dirkje S. Postma, Rasika A. Mathias

Publikováno v: PLoS ONE
PLoS ONE, 8(2):e56179. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 8, Iss 2, p e56179 (2013)

Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6926ae77e525e9e202eeea1d32e6701
https://doi.org/10.1371/journal.pone.0056179

Allergen Exposure, African Ancestry, And Asthma In Puerto Rican Children

Autor: Jody Senter-Sylvia, Maria Alvarez, Juan C. Celedón, John Brehm, Edna Acosta-Pérez, Erick Forno, Deanna Calvert, Angel Colón-Semidey, Dorothy Wakefield, Glorisa Canino, Michelle M. Cloutier, Soma Datta, Sherell Thornton-Thompson, Kathryn Paul

Publikováno v: C27. EVALUATION AND MANAGEMENT OF DIFFICULT ASTHMA POPULATIONS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bef16999b1323a6205c31925c1a5485b
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4074