Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Jody Rosenblatt"'
Autor:
Jennifer Rynne, Elena Ortiz-Zapater, Dustin C. Bagley, Onofrio Zanin, George Doherty, Varsha Kanabar, Jon Ward, David J. Jackson, Maddy Parsons, Jody Rosenblatt, Ian M. Adcock, Rocio T. Martinez-Nunez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA expression between health and asthma. How
Externí odkaz:
https://doaj.org/article/025cfd2596af4524902ab41889482181
Autor:
Elena Ortiz-Zapater, Dustin C. Bagley, Virginia Llopis Hernandez, Luke B. Roberts, Thomas J. A. Maguire, Felizia Voss, Philipp Mertins, Marieluise Kirchner, Isabel Peset-Martin, Grzegorz Woszczek, Jody Rosenblatt, Michael Gotthardt, George Santis, Maddy Parsons
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The epithelial protein Coxsackievirus Adenovirus Receptor (CAR) is a virus receptor but may have other functions. Here the authors show that deletion of CAR in mice leads to reduced house dust mite-induced lung inflammation, reduced neutrophil accumu
Externí odkaz:
https://doaj.org/article/c3d25d33aea74f4cbf6de6ff469281a8
Autor:
John Fadul, Teresa Zulueta-Coarasa, Gloria M. Slattum, Nadja M. Redd, Mauricio Franco Jin, Michael J. Redd, Stephan Daetwyler, Danielle Hedeen, Jan Huisken, Jody Rosenblatt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The ability to visualise stochastic invasion events is limited in murine models of metastatic cancers. Here the authors use a transparent zebrafish epidermis model to follow the invasion events of K-Ras transformed epithelial cells and show that thes
Externí odkaz:
https://doaj.org/article/61d4a58f438f4d42b3f1128793ae1242
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105330- (2022)
Summary: Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRasV12-transformed cells can invade directly from the epithelium by basal ce
Externí odkaz:
https://doaj.org/article/f7547226e5044eef84e5060ef88bcd7d
Autor:
Yapeng Gu, Jill Shea, Gloria Slattum, Matthew A Firpo, Margaret Alexander, Sean J Mulvihill, Vita M Golubovskaya, Jody Rosenblatt
Publikováno v:
eLife, Vol 4 (2015)
When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P2 receptors in neighboring cells that seamlessly squeeze the cell out of the epitheliu
Externí odkaz:
https://doaj.org/article/6ecc487c72f740f38bdbf58b1f7720b4
Publikováno v:
bioRxiv
Epithelial cells work collectively to provide a protective barrier, yet also turn over rapidly by cell death and division. If the number of dying cells does not match those dividing, the barrier would vanish, or tumors can form. Mechanical forces and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201047d048fc2f8ece895ef5a97a2f4c
https://doi.org/10.1101/2023.03.13.532421
https://doi.org/10.1101/2023.03.13.532421
Autor:
Saranne J Mitchell, Jody Rosenblatt
Publikováno v:
Curr Opin Cell Biol
Epithelial cells use the process of extrusion to promote cell death while preserving a tight barrier. To extrude, a cell and its neighbors contract actin and myosin circumferentially and basolaterally to seamlessly squeeze it out of the epithelium. R
Autor:
Carlos Pardo-Pastor, Daniel P. Denning, Nolan Tucker, Vivek K. Dwivedi, Rita Droste, Jody Rosenblatt, Ji Na Kong, H. Robert Horvitz
Publikováno v:
Nature. 593:591-596
Cell extrusion is a mechanism of cell elimination that is used by organisms as diverse as sponges, nematodes, insects and mammals1–3. During extrusion, a cell detaches from a layer of surrounding cells while maintaining the continuity of that layer
Autor:
Jody Rosenblatt, Carlos Pardo-Pastor
SummaryEGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. Both the soluble extracellular ligand, EGF, and mechanical inputs like matrix stiffness, cell adhesion, or stretch activate EGFR-ERK signaling. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b104f076195f7fe7dc4172fdcb72135
https://doi.org/10.1101/2022.05.10.490586
https://doi.org/10.1101/2022.05.10.490586
Autor:
Carlos Pardo-Pastor, Jody Rosenblatt
Publikováno v:
Biophysical Journal. 122:160a