Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Jody M, Mason"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-15 (2024)
Abstract Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurodegeneration is evident, but the u
Externí odkaz:
https://doaj.org/article/b84b2ce52d414462b8e67e2f70fbe8f0
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-protein interactions too large for inhibition by small molecules, and inaccessible to larger biologics. In the past two de
Externí odkaz:
https://doaj.org/article/aed8144564684655ade3c7b5783c548d
Autor:
T. M. Simon Tang, Jody M. Mason
Publikováno v:
JACS Au, Vol 3, Iss 12, Pp 3290-3296 (2023)
Externí odkaz:
https://doaj.org/article/e515b7bf8c7048a39397efa172703024
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Parkinson’s is the second most common neurodegenerative disease, with the number of individuals susceptible due to increase as a result of increasing life expectancy and a growing worldwide population. However, despite the number of indivi
Externí odkaz:
https://doaj.org/article/cb4f050b8d254f639b111877635ff49c
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, su
Externí odkaz:
https://doaj.org/article/b5e15fa34e2d4140938f5ec859024aa4
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Abstract The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant genes is controlled by the cellular
Externí odkaz:
https://doaj.org/article/a74c30741d17430dad190e39bcd21a64
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-14 (2019)
Abstract Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). All diseases are d
Externí odkaz:
https://doaj.org/article/5059d302e214494eacdaf69598ae8ffc
Autor:
Katriona L. Hole, Lydia E. Staniaszek, Gayathri Menon Balan, Jody M. Mason, Jon T. Brown, Robert J. Williams
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer’s Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor
Externí odkaz:
https://doaj.org/article/7c25e2f2c9814601ab0b951a342a7015
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development for a range of neurodegenerative conditions, collectively termed synucleinopathies. Here, we probe the mechanism of action of a peptide 4554W, (KDGIVNGVKA), previousl
Externí odkaz:
https://doaj.org/article/4b84b3dabe714962abc73dfd7706266d
Autor:
Emad Darvishi, Lila Ghamsari, Siok F. Leong, Ricardo Ramirez, Mark Koester, Erin Gallagher, Miao Yu, Jody M. Mason, Gene Merutka, Barry J. Kappel, Jim A. Rotolo
Publikováno v:
Mol Cancer Ther
CCAAT/enhancer binding protein β (C/EBPβ) is a basic leucine zipper (bZIP) family transcription factor, which is upregulated or overactivated in many cancers, resulting in a gene expression profile that drives oncogenesis. C/EBPβ dimerization regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e846fbe37dd9048d137176c67763eb8
https://doi.org/10.1158/1535-7163.mct-21-0962
https://doi.org/10.1158/1535-7163.mct-21-0962