Výsledky vyhledávání - "Jody L. Knauss"

Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro

Autor: J. Oler, David Bleakman, Jody L. Knauss, Brianne Weiss, T.H. Large, Ken H. Ho, Andrew Alt, Ann-Marie Ogden

Publikováno v: Neuropharmacology. 46:793-806

An increasing body of evidence suggests that native kainate receptors form ion channels from homomeric and heteromeric combinations of five receptor subunits: GluR5, GluR6, GluR7, KA1 and KA2. We have examined the activity of agonists and antagonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fb597a2649fef4faec91ffebacbfe5
https://doi.org/10.1016/j.neuropharm.2003.11.026

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Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists

Autor: Julia C. A. More, Olli T. Pentikäinen, Andrew Alt, David E. Jane, Jody L. Knauss, Mark Mayer, Graham L. Collingridge, Nigel P. Dolman, Carla R. Glasser, David Bleakman

Publikováno v: Journal of medicinal chemistry. 50(7)

Some N3-substituted analogues of willardiine such as 11 and 13 are selective kainate receptor antagonists. In an attempt to improve the potency and selectivity for kainate receptors, a range of analogues of 11 and 13 were synthesized with 5-substitue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d78e8cdba71299fd44215d3c3115c06
https://pubmed.ncbi.nlm.nih.gov/17348638

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Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists

Autor: Julia C. A. More, David E. Jane, Graham L. Collingridge, David Bleakman, Jody L. Knauss, Helen M Troop, Andrew Alt, Nigel P. Dolman

Publikováno v: Journal of medicinal chemistry. 49(8)

N3-substitution of the uracil ring of willardiine with a variety of carboxyalkyl or carboxybenzyl substituents produces AMPA and kainate receptor antagonists. In an attempt to improve the potency and selectivity of these AMPA and kainate receptor ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4be89fe1089a0b7988e8bccaac13e48
https://pubmed.ncbi.nlm.nih.gov/16610801

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Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors

Autor: David Bleakman, Nigel P. Dolman, Samantha Jack, David E Jane, Richard M. Morley, Julia C. A. More, Andrew Alt, Zuner A. Bortolotto, Robert Nisticò, Peter J. Roberts, Helen M Troop, Jody L. Knauss, Graham L. Collingridge

Publikováno v: Journal of medicinal chemistry. 48(24)

The natural product willardiine (8) is an AMPA receptor agonist while 5-iodowillardiine (10) is a selective kainate receptor agonist. In an attempt to produce antagonists of kainate and AMPA receptors analogues of willardiine with substituents at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251754fe7ba85f935de7c0d98faf024f
https://pubmed.ncbi.nlm.nih.gov/16302825

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Akademický článek

Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5Kainate Receptor Antagonists.

Autor: Nigel P. Dolman, Julia C. A. More, Andrew Alt, Jody L. Knauss, Olli T. Pentikäinen, Carla R. Glasser, David Bleakman, Mark L. Mayer, Graham L. Collingridge, David E. Jane

Publikováno v: Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 7, p1558-1570, 13p

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