Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jody Khosla"'
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 27:345-352
Responses of isolated type II alveolar cells to fibroblast growth factors (FGF) have been shown to be sensitive to the level of sulfation in extracellular matrix (ECM) substrata. These observations may reflect the specific in situ distribution and le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde31f5fba0d33d48a72cd83c6b328c3
https://doi.org/10.1165/rcmb.2002-0002oc
https://doi.org/10.1165/rcmb.2002-0002oc
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 279:L1038-L1046
Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factor (TGF)-β1, an important inflammatory cytokine, in vascular epithelium. The goal of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d90747e2b6a5e6a60a16a7439c2baa
https://doi.org/10.1152/ajplung.2000.279.6.l1038
https://doi.org/10.1152/ajplung.2000.279.6.l1038
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L840-L847
The aim of this study was to determine the extent to which sulfate incorporated into biosynthesized basement membrane (BM) components increased as isolated type II cells progress toward a more type I cell-like phenotype from 7 to 21 days in culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40806421002f879efe12cbd0aa964c84
https://doi.org/10.1152/ajplung.1997.273.4.l840
https://doi.org/10.1152/ajplung.1997.273.4.l840
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 271:L688-L697
The pulmonary alveolar basement membrane (BM) associated with alveolar type II cells has been shown to be significantly less sulfated than that of type I cells. To examine the biological significance of this observation, we measured the incorporation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7ec800da914737da3b5e717607f918
https://doi.org/10.1152/ajplung.1996.271.5.l688
https://doi.org/10.1152/ajplung.1996.271.5.l688
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 8:245-251
Histologic preparations of lungs from 1-, 5-, 10-, 18-, and 25-day-old postnatal and adult rats were examined immunohistochemically with antibodies specific against chondroitin sulfate (CS), basement membrane chondroitin sulfate proteoglycan (BM-CSPG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308655a1f19212210339b7631b6cdd56
https://doi.org/10.1165/ajrcmb/8.3.245
https://doi.org/10.1165/ajrcmb/8.3.245
Autor:
Donna R. Newman, K. B. C. Apparao, Philip L. Sannes, Jody Khosla, Scott H. Randell, Huiying Zhang
Pre- and postnatal developmental studies of the lung have provided compelling evidence demonstrating multiple factors that orchestrate alveolar epithelial cell differentiation. The extent to which reactivation of certain developmental pathways in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a817ccd0743c04e99567bb615f31882d
Publikováno v:
Respiratory Research, Vol 8, Iss 1, p 36 (2007)
Respiratory Research
Respiratory Research
BackgroundHeparin has been shown to modify fundamental biologic processes ranging from blood coagulation and cell proliferation to fibrogenesis and asthma. The goal of this study was to identify specific or broad biologic responses of the rat lung to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7a3391aad2a2564937624efe69743c
http://respiratory-research.com/content/8/1/36
http://respiratory-research.com/content/8/1/36
The stimulation and maintenance of the pulmonary alveolar type II cell's capacity to biosynthesize, store, and secrete surfactant proteins (SPs) are modulated to a great extent by growth factors, extracellular matrix (ECM) components, and hormones. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde03a3b754de056cb0638d417697473
https://europepmc.org/articles/PMC2643279/
https://europepmc.org/articles/PMC2643279/
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 287(1)
Undersulfation of the basement membrane matrix of alveolar type II (AT2) cells compared with that of neighboring type I cells is believed to account for some of the known morphological and functional differences between these pneumocytes. Heparin, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd6aeb9df2485a1401eda755ed2400e
https://pubmed.ncbi.nlm.nih.gov/14966081
https://pubmed.ncbi.nlm.nih.gov/14966081
Autor:
Philip L. Sannes, Jody Khosla, Leslie Tompkins, Cheng-Ming Li, Donna R. Newman, Mark F. Cesta
Publikováno v:
Chest. 123
repair and wound healing. PDGFs are synthesized and secreted by most inflammatory cell types present within the milieu of the asthmatic airway. We have previously reported that airway fibroblasts from severe asthmatics produce more type I procollagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe550de166a0d2d0caa4e8003bef19ee
https://pubmed.ncbi.nlm.nih.gov/12629019
https://pubmed.ncbi.nlm.nih.gov/12629019