Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jody Bozek"'
Autor:
Ming Yu, Paula Silva, Mary Guaraldi, Mikhail Kagan, Jody Bozek, Simon P. Robinson, Michael Azure, David C. Onthank
Publikováno v:
Nuclear Medicine and Biology. 40:682-688
Introduction Released sympathetic neurotransmitter norepinephrine (NE) in the heart is cleared by neuronal uptake-1 and extraneuronal uptake-2 transporters. Cardiac uptake-1 and -2 expression varies among species, but the uptake-1 is the primary tran
Autor:
Mahesh Mistry, Padmaja Yalamanchili, Michael Azure, David S. Casebier, Ming Yu, Mikhail Kagan, Jody Bozek, Mary Guaraldi, Megan Hayes, Ajay Purohit, Jennifer McDonald, Radeke Heike S, Simon P. Robinson
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 36:63-72
Myocardial extractions of mitochondria complex I (MC-I) inhibitors were high and well correlated with flow. This study assessed the potential of MC-I inhibitors to be developed as myocardial perfusion imaging (MPI) agents.RP1003, RP1004, and RP1005 r
Autor:
David S. Casebier, Mikhail Kagan, Ming Yu, Ajay Purohit, Padmaja Yalamanchili, Michael Azure, Eric Wexler, Jody Bozek, Radeke Heike S, Simon P. Robinson, Megan Hayes
Publikováno v:
Journal of Nuclear Cardiology. 14:782-788
Background BMS-747158-02 is a novel fluorine 18–labeled pyridazinone derivative designed for cardiac imaging. The uptake and retention mechanisms of F-18 BMS-747158-02 in cardiac myocytes were studied in vitro, and the biodistribution of F-18 BMS-7
Autor:
Mikhail Kagan, Ming Yu, David C. Onthank, Pedro Benites, Simon P. Robinson, Melanie Lamoy, Jody Bozek
Publikováno v:
European journal of nuclear medicine and molecular imaging. 39(12)
Regional cardiac sympathetic denervation (RCSD) associated with reduced noradrenaline transporter (NAT) function has been linked to cardiac arrhythmia. This study examined the association of LMI1195, an (18)F-labeled NAT substrate developed for posit
Autor:
Padmaja Yalamanchili, Paula Silva, Joel Lazewatsky, Melanie Lamoy, David S. Casebier, Mikhail Kagan, Jody Bozek, Ajay Purohit, Mahesh Mistry, Michael Cdebaca, Mary Guaraldi, Radeke Heike S, Ming Yu, Richard R. Cesati, Matthias Broekema, Michael Azure, Simon P. Robinson, David C. Onthank
Publikováno v:
Circulation. Cardiovascular imaging. 4(4)
Background— Heart failure has been associated with impaired cardiac sympathetic neuronal function. Cardiac imaging with radiolabeled agents that are substrates for the neuronal norepinephrine transporter (NET) has demonstrated the potential to iden
Autor:
David S. Casebier, Melanie Lamoy, Mikhail Kagan, Ming Yu, Joel Lazewatsky, Mary Guaraldi, Jody Bozek, Simon P. Robinson, Mahesh Mistry, Ajay Purohit, Radeke Heike S, Richard R. Cesati, Paula Silva, Michael Azure, David C. Onthank, Matthias Broekema
Publikováno v:
Journal of the American College of Cardiology. 55(10)
Publikováno v:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 17(4)
BMS747158 labeled with (18)F is being developed for PET myocardial perfusion imaging. Imaging studies showed clear detection of necrotic tissue in acute myocardial infarcted (MI) animals and a good safety profile in normal animals. This study evaluat