Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jody, Mayfield"'
Publikováno v:
Neurobiology of Stress, Vol 31, Iss , Pp 100639- (2024)
Toll-like receptors (TLRs) are a family of innate immune receptors that recognize molecular patterns in foreign pathogens and intrinsic danger/damage signals from cells. TLR7 is a nucleic acid sensing endosomal TLR that is activated by single-strande
Externí odkaz:
https://doaj.org/article/552b95dd390742978719e32c396679de
Publikováno v:
Neuropharmacology. 231:109508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2748cb1f5a1bd446fdec61ef0dbf204
https://doi.org/10.1016/j.neuropharm.2023.109508
https://doi.org/10.1016/j.neuropharm.2023.109508
Autor:
Yuri A, Blednov, Adriana, Da Costa, Sonia, Mason, Jody, Mayfield, Stephen J, Moss, Robert O, Messing
Publikováno v:
Neuropharmacology. 220:109255
We previously showed that apremilast, an FDA-approved PDE4 inhibitor, selectively alters behavioral responses to ethanol and certain GABAergic drugs in a PKA-dependent manner in C57BL6/J mice. Here, we investigated if PKA phosphorylation of β3 GABAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382849cda7a2a48e4aed7ec72354c49f
https://doi.org/10.1016/j.neuropharm.2022.109255
https://doi.org/10.1016/j.neuropharm.2022.109255
Publikováno v:
Addict Biol
Pharmacological studies implicate toll-like receptor 3 (TLR3) signaling in alcohol drinking. We examined the role of TLR3 in behavioral responses to alcohol and GABAergic drugs by studying Tlr3 (−/−) mice. Because of opposing signaling between TL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6039617e07354be5bad2add7eac7b7
https://doi.org/10.1111/adb.12932
https://doi.org/10.1111/adb.12932
Autor:
Adriana Da Costa, Jody Mayfield, Jillian M. Benavidez, Mendy Black, Yuri A. Blednov, R. Adron Harris
Publikováno v:
Alcoholism: Clinical and Experimental Research. 41:531-540
Background In our companion article, we examined the role of MyD88-dependent signaling in ethanol (EtOH) consumption in mice lacking key components of this inflammatory pathway and observed differential effects on drinking. Here, we studied the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5042532402f002f1e3843019472f772b
https://doi.org/10.1111/acer.13314
https://doi.org/10.1111/acer.13314
Autor:
Jody Mayfield, Julia Chernis, Adriana Da Costa, Mendy Black, Yuri A. Blednov, R. Adron Harris
Publikováno v:
Alcoholism: Clinical and Experimental Research. 41:516-530
Background Molecular and behavioral studies support a role for innate immune proinflammatory pathways in mediating the effects of alcohol. Increased levels of Toll-like receptors (TLRs) have been observed in animal models of alcohol consumption and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f3f5f3a770775b5545af6f14bc069e
https://doi.org/10.1111/acer.13316
https://doi.org/10.1111/acer.13316
Autor:
Adriana Da Costa, Amy W. Lasek, Amanda J. Roberts, Robert Hitzemann, Jody Mayfield, Gregg E. Homanics, Michal Bajo, Yuri A. Blednov, R. A. Harris, Marisa Roberto, Stephanie Edmunds, Mendy Black
Publikováno v:
Genes Brain Behav
The voltage-gated sodium channel subunit β4 (SCN4B) regulates neuronal activity by modulating channel gating and has been implicated in ethanol consumption in rodent models and human alcoholics. However, the functional role for Scn4b in ethanol-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29811d8c9624e9eb24ad1363b38fe34c
https://pubmed.ncbi.nlm.nih.gov/30817077
https://pubmed.ncbi.nlm.nih.gov/30817077
Publikováno v:
Neuropharmacology. 95:309-320
Gene expression studies identified the interleukin-1 receptor type I (IL-1R1) as part of a pathway associated with a genetic predisposition to high alcohol consumption, and lack of the endogenous IL-1 receptor antagonist (IL-1ra) strongly reduced eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996b837cc002744ec1e60798b6a3f2f5
https://doi.org/10.1016/j.neuropharm.2015.03.015
https://doi.org/10.1016/j.neuropharm.2015.03.015
Autor:
Florence P. Varodayan, Jay M. Truitt, Edward Roberts, Leandro F. Vendruscolo, Yuri A. Blednov, Giordano de Guglielmo, Richard L. Bell, David J. Hackam, R. Adron Harris, Amy W. Lasek, Amanda J. Roberts, Timothy R. Billiar, Marisa Roberto, R. Dayne Mayfield, Olivier George, Jody Mayfield, Michal Bajo, George F. Koob, Gregg E. Homanics, Marian L. Logrip
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 37, iss 5
Toll-like receptor 4 (TLR4) is a critical component of innate immune signaling and has been implicated in alcohol responses in preclinical and clinical models. Members of the Integrative Neuroscience Initiative on Alcoholism (INIA-Neuroimmune) consor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25c7b75b1b5d046d7799a18afad321f
https://escholarship.org/uc/item/6z66r50d
https://escholarship.org/uc/item/6z66r50d
Publikováno v:
Current Opinion in Neurobiology. 23:513-520
Molecular and behavioral studies corroborate a pivotal role for the innate immune system in mediating the acute and chronic effects of alcohol and support a neuroimmune hypothesis of alcohol addiction. Changes in expression of neuroimmune genes and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684543933e18d9633a6663db10b128cb
https://doi.org/10.1016/j.conb.2013.01.024
https://doi.org/10.1016/j.conb.2013.01.024