Výsledky vyhledávání

Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1

Autor: Benjamin N, Atkinson, Nicky J, Willis, Jennifer, Smith, Rebecca, Gill, Jody, Ali, Zhou, Xu, Ping-Shan, Lai, Paul V, Fish

Publikováno v: RSC advances. 12(41)

1-Phenyl-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30181eb9e0169a716f6a66ed1cd3f3de
https://pubmed.ncbi.nlm.nih.gov/36275171

Zobrazit plný text záznamu

Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1H-1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step

Autor: Benjamin N. Atkinson, Nicky J. Willis, Jennifer Smith, Rebecca Gill, Jody Ali, Zhou Xu, Ping-Shan Lai, Paul V. Fish

1-Phenyl-1H-1,2,3-triazole 1 (ARUK3001185) was prepared on large scale from aniline 4 by application of both (1) a copper catalyzed azide-alkyne cycloaddition (CuAAC) with (trimethylsilyl)acetylene, and (2) a Clark modification of the Sakai reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf0c4165b4fd2acdb0efbe7c2d45e04
https://doi.org/10.26434/chemrxiv-2022-4vzgh

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání