A Type III Complement Factor D Deficiency: Structural insights for inhibition of the alternative pathway

Autor: Sng, CCT, O’Byrne, S, Prigozhin, DM, Bauer, MR, Harvey, JC, Ruhle, M, Challis, BG, Lear, S, Roberts, LD, Workman, S, Janowitz, T, Magiera, L, Doffinger, R, Buckland, MS, Jodrell, DJ, Semple, RK, Wilson, TJ, Modis, Y, Thaventhiran, JED

Publikováno v: The Journal of Allergy and Clinical Immunology
Sng, C C T, O'Byrne, S, Prigozhin, D M, Bauer, M R, Harvey, J C, Ruhle, M, Challis, B G, Lear, S, Roberts, L D, Workman, S, Janowitz, T, Magiera, L, Doffinger, R, Buckland, M S, Jodrell, D J, Semple, R K, Wilson, T J, Modis, Y & Thaventhiran, J E D 2018, ' A type III complement factor D deficiency : Structural insights for inhibition of the alternative pathway ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2018.01.048
The Journal of allergy and clinical immunology, vol 142, iss 1
Sng, Christopher CT; O'Byrne, Sorcha; Prigozhin, Daniil M; Bauer, Matthias R; Harvey, Jennifer C; Ruhle, Michelle; et al.(2018). A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.. The Journal of allergy and clinical immunology, 142(1), 311-314.e6. doi: 10.1016/j.jaci.2018.01.048. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9j831648

Background: Complement factor D (FD) is the rate-limiting enzyme of the alternative complement pathway. Previous reports of FD deficiency featured absent plasma FD (type I deficiency) and susceptibility to meningococcal infection. A new FD mutant, wh

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https://eprints.whiterose.ac.uk/128452/8/1-s2.0-S0091674918303270-main.pdf