Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jodie Y. Duffy"'
Autor:
Pirooz Eghtesady, R. Scott Baker, Christopher T. Lam, Walt Lubbers, Mitali Basu, Emily A. Heeb, Jodie Y. Duffy
Publikováno v:
The Annals of Thoracic Surgery. 87:841-847
Background. We previously showed cyclic guanosine 3’,5’-monophosphate (cGMP) levels increase with fetal cardiac bypass despite derangements in the placental nitric oxide pathway. The natriuretic peptides, atrial (ANP), brain (BNP), and c-type (CN
Autor:
Jodie Y. Duffy, Karen M. D'Souza, Kelly M. McLean, Walter H. Merrill, Shahab A. Akhter, Christian F. Bulcao, Prakash K. Pandalai, Jeffrey M. Pearl
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 135(4):792-798
Objective β-Adrenergic receptor desensitization through activation of the G protein–coupled receptor kinase 2 is an important mechanism of early cardiac dysfunction after brain death. We hypothesized that acute β-blockade can prevent myocardial
Autor:
Jeffrey M. Pearl, Timothy P. O'Neill, Jodie Y. Duffy, Jefferson M. Lyons, Robert A. Kaiser, Connie J. Wagner, Jeffery D. Molkentin, Kelly M. McLean
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 289:H2747-H2751
The MAPK family member p38 is activated in the heart after ischemia-reperfusion (I/R) injury. However, the cardioprotective vs. proapoptotic effects associated with p38 activation in the heart after I/R injury remain unresolved. Another issue to cons
Autor:
Shahab A. Akhter, Kelly M. McLean, Prakash K. Pandalai, Jeffrey M. Pearl, Jefferson M. Lyons, Connie J. Wagner, Jodie Y. Duffy
Publikováno v:
The Journal of Heart and Lung Transplantation. 24:2249-2254
Traumatic brain injury and subsequent brain death (BD) account for nearly half of all organ donors, yet only 33% of available hearts are transplanted. Alterations in multiple physiologic pathways after BD can lead to cardiac dysfunction and exclusion
Autor:
Prakash K. Pandalai, Walter H. Merrill, Jodie Y. Duffy, Connie J. Wagner, Jefferson M. Lyons, Kelly M. McLean, Jeffrey M. Pearl, Shahab A. Akhter
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 130(4):1183-1189
Significant cardiac dysfunction after brain death leading to exclusion from procurement for cardiac transplantation is seen in up to 25% of potential organ donors in the absence of structural heart disease. The cause includes uncoupling of the myocar
Publikováno v:
Journal of Cardiac Surgery. 19:254-257
Background: The extracardiac Fontan arose as an alternative in order to prevent the classical procedure's sequelea. Complications of the extracardiac Fontan have been described, but this case report aims to highlight the devastating and infrequent co
Autor:
Jeffrey M. Pearl, Jefferson M. Lyons, Steven M. Bauer, Jerri L McNamara, Connie J. Wagner, Steven M. Schwartz, David P. Nelson, Jodie Y. Duffy
Publikováno v:
Pediatric Critical Care Medicine. 5:28-34
OBJECTIVE The hypotheses were that glucocorticoid administration could improve ventricular recovery by reducing cardiopulmonary bypass (CPB)-induced inflammatory response and that presurgical administration might be more effective than intraoperative
Autor:
Steven M. Bauer, Elizabeth A. Setser, Connie J. Wagner, Jeffrey M. Pearl, David P. Nelson, Jodie Y. Duffy, Steven M. Schwartz
Publikováno v:
The Annals of Thoracic Surgery. 74:830-837
Transient myocardial dysfunction often occurs after ischemia-reperfusion with immature myocardium appearing particularly susceptible. Neutrophil adhesion and activation contribute to ischemia-reperfusion injury after cardiopulmonary bypass (CPB), pos
Autor:
Thomas P. Shanley, Jenni L. Raake, Hector R. Wong, Peter B. Manning, Jeffrey M. Pearl, Steven M. Schwartz, Lisa Koons, David P. Nelson, Jodie Y. Duffy
Publikováno v:
Critical Care Medicine. 30:89-93
Inhaled nitric oxide (iNO) is front-line therapy for pulmonary hypertension after repair of congenital heart disease. However, little clinical data exists regarding the effects of iNO on regulators of pulmonary vascular resistance. An imbalance betwe
Publikováno v:
Critical Care Medicine. 29:S214-S219
Disruption of any one of a large number of balanced systems that maintain cardiomyocyte structure and function can cause myocardial dysfunction. Such disruption can occur either in response to acute stresses such as cardiac surgery with cardiopulmona