Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jodie Mussio"'
Publikováno v:
Toxicology and applied pharmacology. 360
Targeting the anti-apoptotic protein Mcl-1 holds a promise to improve therapy of multiple types of Mcl-1 dependent cancers but raises concerns of on-target cardiotoxicity due to the presence and reported role of Mcl-1 in heart. Herein, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b6489b870c9f90a415c0e7894bb209
https://pubmed.ncbi.nlm.nih.gov/30268579
https://pubmed.ncbi.nlm.nih.gov/30268579
Publikováno v:
Current protocols in chemical biology. 7(3)
There is a need to develop mechanism-based assays to better inform risk of cardiotoxicity. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are rapidly gaining acceptance as a biologically relevant in vitro model for use in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47bd846e6f98f90226475c23ccd15166
https://pubmed.ncbi.nlm.nih.gov/26331525
https://pubmed.ncbi.nlm.nih.gov/26331525
Autor:
Holger P. Behrsing, John Hamre, Sandy Eldridge, Myrtle Davis, Facundo M. Cutuli, Liang Guo, Jodie Mussio
Publikováno v:
Toxicological Sciences. :kfw254
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting adverse effect experienced by cancer patients. Advancements in mechanism-based risk mitigation and effective treatments for CIPN can be aided by suitable in vitro assays. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8b0866186dd51fc407fe7ad910adcb
https://doi.org/10.1093/toxsci/kfw254
https://doi.org/10.1093/toxsci/kfw254