Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jodie C. E. Hall"'
Autor:
Faith H. Brennan, Yang Li, Cankun Wang, Anjun Ma, Qi Guo, Yi Li, Nicole Pukos, Warren A. Campbell, Kristina G. Witcher, Zhen Guan, Kristina A. Kigerl, Jodie C. E. Hall, Jonathan P. Godbout, Andy J. Fischer, Dana M. McTigue, Zhigang He, Qin Ma, Phillip G. Popovich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Here the authors show, using microglia-specific depletion techniques and single cell transcriptomics, that optimal repair after murine spinal cord injury (SCI) requires microglia.
Externí odkaz:
https://doaj.org/article/c71897bb4488416ab0aceb965a3c158b
Autor:
Randall S. Carpenter, Jessica M. Marbourg, Faith H. Brennan, Katherine A. Mifflin, Jodie C. E. Hall, Roselyn R. Jiang, Xiaokui M. Mo, Malith Karunasiri, Matthew H. Burke, Adrienne M. Dorrance, Phillip G. Popovich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration
Externí odkaz:
https://doaj.org/article/0d1de6f876b2431485cb553f43443b20
Autor:
Camila Marques Freria, Steve Lacroix, Xiaoyu Liu, Faith H. Brennan, Zhen Guan, Kristina A. Kigerl, Dániel Németh, David R Sweet, Ning Quan, Jodie C. E. Hall, Phillip G. Popovich
Publikováno v:
J Neurosci
Microglia are dynamic immunosurveillance cells in the CNS. Whether microglia are protective or pathologic is context dependent; the outcome varies as a function of time relative to the stimulus, activation state of neighboring cells in the microenvir
Autor:
Faith H. Brennan, Phillip G. Popovich, Jessica M. Marbourg, Katherine A. Mifflin, Adrienne M. Dorrance, Xiaokui M. Mo, Randall S. Carpenter, Matthew H. Burke, Roselyn R. Jiang, Jodie C. E. Hall, Malith Karunasiri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious morbidity and mortality. Since bone marrow hematopoiesis is essential for proper immune function, we hypothesize that SCI disrupts bone marrow hematopoiesis. Indeed
Autor:
Phillip G. Popovich, Manoj K. Gottipati, Faith H. Brennan, Stefan Niewiesk, Randall S. Carpenter, Jodie C. E. Hall, Roselyn R. Jiang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Humanized mice can be used to better understand how the human immune system responds to central nervous system (CNS) injury and inflammation. The optimal parameters for using humanized mice in preclinical CNS injury models need to be established for
Autor:
Phillip G. Popovich, Camila Marques Freria, Ping Wei, Zhen Guan, Jodie C. E. Hall, Dana M. McTigue
Publikováno v:
The Journal of Neuroscience. 37:3568-3587
Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic spinal contusion injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Here, we tested the hypothesis that
Autor:
Tracey Baskerville, T. H. Richard Ip, Adina T. Michael-Titus, Moumin A. E. K. Mohamed, Amy L. Bowes, Fanuelle Getachew, John V. Priestley, Ping K. Yip, Zhuo-Hao Liu, Phillip G. Popovich, Anna D. Lindsay, Jodie C. E. Hall, Saif-Ur-Rehman Najeeb, Miguel Angel Burguillos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain incompletely characterized. Docosahexaenoic acid (DHA) has been shown to have significant neuroprotective effects after hemisec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0733edd8ada34aa01120f917323e1fc4
http://hdl.handle.net/10261/214543
http://hdl.handle.net/10261/214543
Autor:
Zhen Guan, Andrew D. Gaudet, Xiaokui Mo, David R Sweet, Shweta Mandrekar-Colucci, Phillip G. Popovich, Philipp J Schmitt, Jodie C. E. Hall, Xinyang Xu, Mireia Guerau-de-Arellano
Publikováno v:
Journal of Neuroscience. 36:8516-8532
Axon regeneration after spinal cord injury (SCI) fails due to neuron-intrinsic mechanisms and extracellular barriers including inflammation. microRNA (miR)-155–5p is a small, noncoding RNA that negatively regulates mRNA translation. In macrophages,
Autor:
Zhongtang Yu, Jodie C. E. Hall, Phillip G. Popovich, Xiaokui Mo, Kristina A. Kigerl, Lingling Wang
Publikováno v:
The Journal of Experimental Medicine
Kigerl et al. show that spinal cord injury causes profound changes in gut microbiota and that these changes in gut ecology are associated with activation of GALT immune cells. They show that feeding mice probiotics after SCI confers neuroprotection a
Traumatic spinal cord injury (SCI) elicits a robust intraspinal inflammatory reaction that is dominated by at least two major subpopulations of macrophages, i.e., those derived from resident microglia and another from monocytes that infiltrate the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82eab18dc5f1a20b047ce1a626f72eb5
https://doi.org/10.1101/410258
https://doi.org/10.1101/410258