Zobrazeno 1 - 10
of 48
pro vyhledávání: '"JodiAnne T. Wood"'
Publikováno v:
Nutrients, Vol 10, Iss 9, p 1294 (2018)
Recognized as the gold standard, human milk (HM) is an extremely complex yet fascinating biofluid tailored to meet an infant’s nutritional requirements throughout development. Endocannabinoids and endocannabinoid-like compounds (endocannabinoid met
Externí odkaz:
https://doaj.org/article/e7398ed296524449a8e19dbb2c9d4e36
Autor:
JodiAnne T. Wood, John S. Williams, Lakshmipathi Pandarinathan, David R. Janero, Carol J. Lammi-Keefe, Alexandros Makriyannis
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 6, Pp 1416-1423 (2010)
The endocannabinoid metabolome consists of a growing, (patho)physiologically important family of fatty-acid derived signaling lipids. Diet is a major source of fatty acid substrate for mammalian endocannabinoid biosynthesis. The principal long-chain
Externí odkaz:
https://doaj.org/article/3ffac3c7dfb04eb49c204855245c07b1
Autor:
Ioannis P. Papanastasiou, Markos-Orestis Georgiadis, Christos Iliopoulos-Tsoutsouvas, Carol A. Paronis, Christina A. Brust, Ngan K. Tran, Lipin Ji, Xiaoyu Ma, JodiAnne T. Wood, Nikolai Zvonok, Fei Tong, Laura M. Bohn, Spyros P. Nikas, Alexandros Makriyannis
Publikováno v:
European journal of medicinal chemistry. 230
In earlier work, we explored the SAR for the C3 side chain pharmacophore in the hexahydrocannabinol template represented by the drug nabilone, which resulted in the development of AM2389. In an effort for further optimization, we have merged features
Autor:
Gianfranca Carta, JodiAnne T. Wood, Claudia Sagheddu, Sebastiano Banni, Marco Pistis, Alexandros Makriyannis, Michael S. Malamas, Mauro Congiu, Maria Scherma, Paola Fadda
Publikováno v:
Neuropharmacology. 144:327-336
Tobacco smoke is the leading preventable cause of death in the world and treatments aimed to increase success rate in smoking cessation by reducing nicotine dependence are sought. Activation of peroxisome proliferator-activated receptor-alpha (PPARα
Autor:
Yingpeng Liu, Lipin Ji, Spyros P. Nikas, JodiAnne T. Wood, Adriana V. Gaitán, Alexandros Makriyannis, Carol J. Lammi-Keefe
Publikováno v:
Journal of human lactation : official journal of International Lactation Consultant Association. 37(4)
Background Dietary long-chain polyunsaturated fatty acids are known to benefit infant development. After birth, human milk provides arachidonic, eicosapentaenoic, and docosahexaenoic acids to the infant. Endocannabinoids are endogenous lipid mediator
Autor:
Xiaoyu Ma, Srikrishnan Mallipeddi, Michael S. Malamas, Han Zhou, Alexandros Makriyannis, Chandrashekhar Honrao, Othman Benchama, JodiAnne T. Wood, Jimit Girish Raghav
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4963-4970
New oximes short-acting CB1 agonists were explored by the introduction of an internal oxime and polar groups at the C3 alkyl tail of Δ8-THC. The scope of the research was to drastically alter two important physicochemical properties hydrophobicity (
Autor:
Nikolai Zvonok, Ken Mackie, Han Zhou, Spyros P. Nikas, Demetris P. Papahatjis, Andrea G. Hohmann, JodiAnne T. Wood, Shu Xu, Simiao Wu, Lipin Ji, Patricia H. Reggio, Marsha R. Eno, Lawrence J. Marnett, Khadijah A. Mohammad, Paula Morales, Yingpeng Liu, Ai-Ling Li, Dow P. Hurst, Shalley N. Kudalkar, Alexandros Makriyannis, Chandrashekhar Honrao, Othman Benchama, Marion Schimpgen
Publikováno v:
Journal of Medicinal Chemistry. 61:8639-8657
The synthesis of potent metabolically stable endocannabinoids is challenging. Here we report a chiral arachidonoyl ethanolamide (AEA) analogue, namely, (13S,1′R)-dimethylanandamide (AMG315, 3a), a high affinity ligand for the CB1 receptor (Ki of 7.
Autor:
Michael S. Malamas, Joseph Anderson, Karen L.G. Farizatto, JodiAnne T. Wood, Alexandros Makriyannis, Michael F. Almeida, Ben A. Bahr, Catherine M. Weerts, Shrouq I. Farah, Manjunath Lamani, Vidyanand G. Shukla
Publikováno v:
Bioorganicmedicinal chemistry. 27(23)
FAAH inhibitors offer safety advantages by augmenting the anandamide levels "on demand" to promote neuroprotective mechanisms without the adverse psychotropic effects usually seen with direct and chronic activation of the CB1 receptor. FAAH is an enz
Autor:
Adriana V. Gaitán, Fan Zhang, Juliana A Donohue, Noel W. Solomons, Lindsay H. Allen, Lipin Ji, Carol J. Lammi-Keefe, Spyros P. Nikas, JodiAnne T. Wood, Yingpeng Liu, Alexandros Makriyannis
Publikováno v:
Current Developments in Nutrition
Background Recognized as the gold-standard ideal fare, human milk has a unique composition that meets infants’ needs throughout development. Endocannabinoids and endocannabinoid-like compounds [endocannabinoid metabolome (ECM)] are endogenous lipid
Autor:
Alex Straiker, Girija Rajarshi, Christina Yume Miyabe, Shakiru O. Alapafuja, Sally Miller, Vidyanand G. Shukla, Michael S. Malamas, Alexandros Makriyannis, JodiAnne T. Wood, Laura Daily, Honrao Chandrashekhar, Alexander Zvonok, Sergiy Tyukhtenko
Publikováno v:
Bioorg Med Chem
Monoacylglycerol lipase (MGL) inhibition provides a potential treatment approach to glaucoma through the regulation of ocular 2-arachidonoylglycerol (2-AG) levels and the activation of CB1 receptors. Herein, we report the discovery of new series of c